Because of the continuous burst of emergency events (EEs) recently, emergency decision making (EDM) has become an active research topic due to its crucial role in relieving and reducing various losses and damages (property, lives, environment, etc.) caused by EEs. Current EDM studies based on prospect theory (PT) have considered decision maker’s (DM’s) psychological behavior, which is very important in the EDM process because it affects DM’s decision behavior directly, particularly under the uncertainty decision environment. However, those studies neglected an important fact that different emergency situations should be handled by different measures to show the pertinence and effectiveness of the emergency response in the real world, which has been taken into consideration in EDM studies based on game theory (GT). Different behavior experiments show that DMs usually have limited rationality when involved in risk and an uncertain decision environment, in which their psychological behavior has distinct impacts on their decision choice and behavior. Nevertheless, the existing studies of EDM based on GT build on an assumption that DMs are totally rational; however, it is obvious that such an assumption is unreasonable and far from the real-world situation. Motivated by these limitations pointed out previously, this study proposes a novel EDM method combining GT and PT that considers not only the DM’s psychological behavior, but also takes different situations’ handling for EEs into account, which is closer to the EDM problems in reality. An example and comparison with other methods are provided to demonstrate the validity and rationality of the proposed method for coping with real-world EDM problems.