Aiming at the problems of complex realization, single control target and difficulty in selecting the optimal zero sequence voltage when the traditional space vector PWM (SVPWM) algorithm is adopted in five-level active neutral-point-clamp (5L-ANPC) converter, a predictive control optimal switching sequence selection (PC-OSSS) method is proposed. The method adopts the SVPWM control strategy base on the line voltage coordinate and then realizes the selection of optimal switching sequence through the multi-objective predictive control method. Firstly, the principle of SVPWM based on line voltage coordinate is introduced, and all switching sequences that can be output are obtained. Secondly, the mathematical models of the floating capacitor (FC) voltage, the neutral point (NP) voltage and the common mode (CM) voltage corresponding to each switch sequence are established. Finally, the optimal switch sequence is selected by using the predictive control method based on priority ranking. Compared with traditional SVPWM, the outstanding advantage of this method is that the traditional qualitative comparison method is replaced by quantitative calculation. The multi-objective control performance of the converter is improved while retaining the advantages of the traditional SVPWM fixed frequency. Finally, the practicability and effectiveness of the proposed control strategy are verified by simulation and experiment.