A C. elegans MAP kinase pathway is required for wild-type display of an L1-specific surface antigen (srf-6 is nsy-1 III)

Foley, Stephen J; Wu, Zheyang; Politz, Samuel M.

doi:10.17912/micropub.biology.000129

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Cited by 2 publications

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“…As well as directly controlling AMP expression in epithelial cells, NSY-1 plays roles in several processes that are related to the interaction of C. elegans with pathogens. It controls the exact nature of the nematode's surface coat (Foley et al 2019), which in turn determines whether or not a microbe can adhere and initiate an infection (e.g. Gravato-Nobre et al 2011;Rouger et al 2014).…”

Section: What Has Been Retainedmentioning

confidence: 99%

C. elegans: out on an evolutionary limb

Pujol

Ewbank

2021

Immunogenetics

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The natural environment of the free-living nematode Caenorhabditis elegans is rich in pathogenic microbes. There is now ample evidence to indicate that these pathogens exert a strong selection pressure on C. elegans, and have shaped its genome, physiology, and behaviour. In this short review, we concentrate on how C. elegans stands out from other animals in terms of its immune repertoire and innate immune signalling pathways. We discuss how C. elegans often detects pathogens because of their effects on essential cellular processes, or organelle integrity, in addition to direct microbial recognition. We illustrate the extensive molecular plasticity that is characteristic of immune defences in C. elegans and highlight some remarkable instances of lineage-specific innovation in innate immune mechanisms.

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Section: What Has Been Retainedmentioning

confidence: 99%