A fabric reinforced small diameter tubular graft for rabbits’ carotid artery defect

Microporous Spongy Scaffolds Based on Biodegradable Elastic Polyurethanes for the Migration and Growth of Host Cells

“…The three-dimensional structure of tissue scaffolds is the critical factor for the regeneration of new tissues, which will regulate the migration behavior of host cells. − For most host cells, the smaller aperture will restrict the cells from migrating and growing into scaffolds, while the larger aperture would lead to insufficient recognition between cellular pseudopods, materials, and inadequate mechanical support. Therefore, the three-dimensional scaffolds with an appropriate pore structure are beneficial for the adhesion, proliferation, and migration of host cells and then facilitate the rapid reconstruction of new tissues. − Additionally, according to previous reports, microporous scaffolds facilitated the transformation of inflammatory cells from M 1 to M 2 , while M 2 inflammatory cells contribute to effective tissue regeneration. , Clearly, it has been reported in our laboratory and by other teams that endothelial cells tend to grow in small pore size scaffolds, while smooth muscle cells (SMCs) fitly grow in large pore size scaffolds. − Furthermore, microporous scaffolds will absorb and retain the nutrients in the surrounding environment, metabolize wastes from cells, and then enhance the vitality of host cells . In short, the surface wettability, degradation, mechanical matching property between the scaffold and the autologous tissue, and biocompatibility are all affected by the three-dimensional structure of scaffolds.…”

“…According to our previous research, a pure PEUU nanofibrous mat exhibited a very high water contact angle and does not contribute to the rapid adhesion of host cells. , The surface wettability of PEEUUs was measured by dynamic water contact angle testing. According to the results in Figure B, the water contact angles of PEEUUs at the 1 s time point were more than 80°.…”

Magnolol Hybrid Nanofibrous Mat with Antibacterial, Anti-Inflammatory, and Microvascularized Properties for Wound Treatment

“…In defect wounds, insufficient local blood supply caused by reduced angiogenesis function also seriously affects the healing process of wounds. Previous research in wound treatment for the past decade has brought solid pieces of evidence that poor angiogenesis at the wound site is the major challenge to noneffective wound healing. ,, As presented in Figure A, immunofluorescence staining of CD31, which is a transmembrane protein expressed early in vascular development, was used to further characterize the angiogenesis in the wounds. As shown in Figure A, the CD31 positive expression of the wounds treated by PSM-2.5 and PSM-5.0 was more powerful than the control group and the PSM-0.0 group at each observed time point (7 and 14 days).…”

PBAT/gelatin hybrid nanofibers based on post-double network bond processing as a promising vascular substitute

“…For the growth of vascular cell and vascular tissue regeneration, the mechanical property of grafts plays an important role. 47 Nanofibers grafts will be subject to the stress of the tissue around the injured blood vessel, such as blood pressure, human traction, etc. , when used for vascular repairing.…”