A Facile and Convenient Synthetic Route to 1-Amino-4,4-bis(trifluoroacetyl)- and 1-Amino-4-trifluoroacetyl-1,3-butadienes

Preparation of α,β-Unsaturated Ketones Bearing a Trifluoromethyl Group and Their Application in Organic Synthesis

“…These ketones can be converted to the 1-amino-4-trifluoroacetyl-1,3-butadienes in the presence of HCl in good yields [100]. Scheme 59.…”

(E)-1,1,1-Trifluoro-6,6-bis(4-methoxyphenyl)hexa-3,5-dien-2-one

“…In summary, a novel trifluoromethyl dienone has been synthesized in high yield and in a complete stereoselective manner through a deacetylation procedure, a route of access scarcely applied to date to obtain this type of fluorinated molecules [19].…”

“…Compound 4 was isolated as a yellow oil in 84% yield (0.152 g). The characterization data for 4 are as follows: 19…”

Methods of synthesis of conjugated ω-amino ketones

“…Compound 16 reacts with various aliphatic and aromatic amines to give substituted diketones 17. Presumably, 27 the putative mechanism of this reaction involves…”