A Facile One‐Pot Synthesis to Dextran‐Based Nanoparticles with Carboxy Functional Groups

Dou, Hongjing; Tang, Minhua; Kim, Sun

doi:10.1002/macp.200500326

Cited by 24 publications

(29 citation statements)

References 41 publications

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“…). ‘Grafting from’ methods include free radical polymerization (ceric ion initiation, the use of Fenton's reagent, γ ‐radiation, thermal initiation and photolysis), controlled/living radical polymerization and ring‐opening polymerization …”

Section: Synthetic Strategies For Polysaccharide‐based Nanocarriersmentioning

confidence: 99%

“…Polysaccharide‐based nanocarriers were prepared by a combined self‐assembly/graft copolymerization approach. In particular, the self‐association is induced by hydrogen bonding between carboxyl groups in the PAA side‐chains and the polysaccharide backbones during the free radical polymerization of the acrylic monomer from polysaccharide chains . Ceric ammonium nitrate (CAN) is used to initiate the free radical polymerization of AA monomers from the polysaccharide chains.…”

Section: Synthetic Strategies For Polysaccharide‐based Nanocarriersmentioning

confidence: 99%

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Saccharide‐based nanocarriers for targeted therapeutic and diagnostic applications

Mukwaya

Wang

Dou

2018

Polymer International

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Many therapeutic and diagnostic agents suffer from short circulation times or poor selectivity resulting in the need for frequent drug administration and adverse side‐effects. On this basis, selective nanocarriers have been used to address most of the drawbacks via the encapsulation or conjugation of therapeutic and diagnostic agents to allow the targeted release of cargo to diseased sites or tumours, while maintaining low levels of cytotoxicity. Saccharides, which can be classified as monosaccharides, disaccharides and oligo/polysaccharides, have demonstrated great potential in the construction of nanocarriers, as well as the targeted guidance of the nanocarriers to diseased tissues. The fabrication of nanocarriers from natural materials such as polysaccharides affords biodegradability and biocompatibility, and in some instances confers targeting capabilities. The most recent progress in saccharide‐based targeted nanocarriers fabricated via facile one‐pot routes or complex two‐pot synthetic routes is reviewed here, with a particular focus on the high efficiency and flexibility of the one‐pot approach. In addition, inspired by the self‐assembly processes involving saccharides that occur in living organisms, particular emphasis is placed on disease‐targeting nanocarriers that are constructed from or modified by saccharides. © 2018 Society of Chemical Industry

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Section: Synthetic Strategies For Polysaccharide‐based Nanocarriersmentioning

confidence: 99%

Section: Synthetic Strategies For Polysaccharide‐based Nanocarriersmentioning

confidence: 99%

Saccharide‐based nanocarriers for targeted therapeutic and diagnostic applications

Mukwaya

Wang

Dou

2018

Polymer International

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“…DLS investigation confirmed the possibility of generalizing this approach to fabricate nanoparticles from HPC and carboxyl-ended surfactants. Besides, because many other water-soluble polysaccharides can also complex with carboxyl-containing macromolecules or surfactants, [7,19,20,32] this approach shows considerable potential in preparing nanoparticles from various water-soluble polysaccharides and carboxyl-ended surfactants.…”

Section: Self-assembly Of Hpc With Other Carboxylended Surfactantsmentioning

confidence: 99%

The Self‐Assembly of Hydroxypropylcellulose and Carboxyl‐Ended Surfactants to Multi‐Morphological Nanoparticles

Dou

Sun

Yang

2006

Macro Chemistry & Physics

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Summary: The self‐assembly of HPC and carboxyl‐ended surfactants such as Deac was studied in the present paper. Nanoparticles with multi‐morphologies were fabricated from HPC and Deac, and their diameter and morphology can be controlled by adjusting the molar ratio of glucose units and Deac and the environmental pH value. We also demonstrated the ubiquity of fabricating multi‐morphological nanoparticles from HPC and other carboxyl‐ended surfactants by substituting PDFOA for Deac, and it was confirmed by DLS characterization that nanoparticles with multi‐morphologies were formed at pH = 0.1. Thus the proposed approach shows a considerable potential to fabricate polysaccharide‐based multi‐morphological nanoparticles from water‐soluble polysaccharides and carboxyl‐ended surfactants.A schematic illustration of the self‐assembly of HPC and Deac to multi‐morphological nanoparticles.magnified imageA schematic illustration of the self‐assembly of HPC and Deac to multi‐morphological nanoparticles.

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“…[6] For example, amphiphilic block copolymers with functionalized hydrophilic blocks can self-assemble into micelles with functional groups on micelle surface, which greatly affect the interaction with proteins and result in different degradation behavior. [7,8] Polyglycidol (PG) is a polyoxirane which has the same backbone structure as PEO but carries one primary hydroxyl group per repeat unit. [9] Besides, PG has been proved to possess good biocompatibility in vitro and in vivo assays.…”

Section: Introductionmentioning

confidence: 99%

The Influence of Pendant Hydroxyl Groups on Enzymatic Degradation and Drug Delivery of Amphiphilic Poly[glycidol‐block‐(ε‐caprolactone)] Copolymers

Mao

Gan

2009

Macromolecular Bioscience

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An amphiphilic diblock copolymer PG-b-PCL with well-controlled structure and pendant hydroxyl groups along hydrophilic block was synthesized by sequential anionic ring-opening polymerization. The micellization and drug release of PG-b-PCL copolymers using pyrene as a fluorescence probe were investigated for determining the influences of copolymer composition and lipase concentration on drug loading capacity and controlled release behavior. The biodegradation of PG-b-PCL copolymers was studied with microspheres as research samples. It has been concluded that the polar hydroxyl groups along each repeat unit of hydrophilic PG block in PG-b-PCL copolymer have great influences on drug encapsulation, drug release, and enzymatic degradation of micelles and microspheres.

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A Facile One‐Pot Synthesis to Dextran‐Based Nanoparticles with Carboxy Functional Groups

Cited by 24 publications

References 41 publications

Saccharide‐based nanocarriers for targeted therapeutic and diagnostic applications

Saccharide‐based nanocarriers for targeted therapeutic and diagnostic applications

The Self‐Assembly of Hydroxypropylcellulose and Carboxyl‐Ended Surfactants to Multi‐Morphological Nanoparticles

The Influence of Pendant Hydroxyl Groups on Enzymatic Degradation and Drug Delivery of Amphiphilic Poly[glycidol‐block‐(ε‐caprolactone)] Copolymers

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