The Influence of Pendant Hydroxyl Groups on Enzymatic Degradation and Drug Delivery of Amphiphilic Poly[glycidol‐<i>block</i>‐(<i>ε</i>‐caprolactone)] Copolymers

Mao, Jing; Gan, Zhihua

doi:10.1002/mabi.200900104

Cited by 22 publications

(8 citation statements)

References 39 publications

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“…Controlled release strategies combined with biomaterials have been widely investigated and applied in biomedical engineering studies, but few cases of precise control of sequential delivery of double agents have been reported . Recently, amphiphilic copolymers have been proposed to deliver antitumor agents sequentially . In consideration of its amphiphilic properties, the loading efficiency of protein in the shell of amphiphilic constructs is expected low, and it is difficult to achieve sequential releases of dual hydrophilic agents, including proteins such as FGF‐2 and BMP‐2.…”

Section: Discussionmentioning

confidence: 99%

“…10,[32][33][34] Recently, amphiphilic copolymers have been proposed to deliver antitumor agents sequentially. 32,35,36 In consideration of its amphiphilic properties, the loading efficiency of protein in the shell of amphiphilic constructs is expected low, and it is difficult to achieve sequential releases of dual hydrophilic agents, including proteins such as FGF-2 and BMP-2. Therefore, a novel release system for dual-GF delivery is highly demanded.…”

Section: Discussionmentioning

confidence: 99%

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Optimization of release pattern of FGF-2 and BMP-2 for osteogenic differentiation of low-population density hMSCs

Lei

Wang²,

Wu³

et al. 2014

J. Biomed. Mater. Res.

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In the modern design, most delivery systems for bone regeneration focus on a single growth factor (GF) or a simple mixture of multiple GFs, overlooking the coordination of proliferation and osteogenesis induced by various factors. In this study, core-shell microspheres with poly-l-lactide core-poly(lactic-co-glycolic acid) shell were fabricated, and two GFs, basic fibroblast growth factor 2 (FGF-2) and bone morphogenetic protein 2 (BMP-2) were encapsulated into the core or/and shell. The effects of different release patterns (parallel or sequential manners) of FGF-2 and BMP-2 from these core-shell microspheres on the osteogenic differentiation of low-population density human mesenchymal stem cells (hMSCs) were investigated and the temporal organization of GF release was optimized. In vitro experiments suggested that induction of osteogenic differentiation of low-population density hMSCs by the sequential delivery of FGF-2 followed by BMP-2 from the core-shell microspheres (group S2) was much more efficient than that by the parallel release of the two factors from uniform microspheres (group U). The osteogenic induction by the sequential delivery of BMP-2 followed by FGF-2 from core-shell microspheres (group S1) was even worse than that from microspheres loaded with BMP-2 in both core and shell (group B), although comparable to the cases of parallel delivery of dual GFs (group P). This study showed the advantages of group S2 microspheres in inducing osteogenic differentiation of low-population density hMSCs and the necessity of time sequence studies in tissue engineering while multiple GFs are involved.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Optimization of release pattern of FGF-2 and BMP-2 for osteogenic differentiation of low-population density hMSCs

Lei

Wang²,

Wu³

et al. 2014

J. Biomed. Mater. Res.

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“…Other important enzymes for polymer/linker degradation include amylase, which degrades PTs containing dextrin (e.g., [ 135 ]) and hydroxyethyl starch (HES) (e.g., [ 136 ]), lipase, which degrades poly-caprolactone based micelles [ 137 ] and matrix metalloproteinases (MMPs), which can liberate drugs from specially designed micelles [ 138 ]. To take advantage of overexpressed enzymes, many PTs have been designed with protease-sensitive linker oligopeptide moieties (e.g., GFLG (Gly-Phe-Leu-Gly) and GLFG (Gly-Leu-Phe-Gly)) designed to be stable in the blood but rapidly cleaved by lysosomal enzymes (cathepsin B or D and others) within the tumor stroma [ 139 ].…”

Section: Hurdle 3: Intracellular Release Of Active Agentmentioning

confidence: 99%

Polymer Therapeutics: Biomarkers and New Approaches for Personalized Cancer Treatment

Atkinson

Andreu

Vicent

2018

JPM

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Polymer therapeutics (PTs) provides a potentially exciting approach for the treatment of many diseases by enhancing aqueous solubility and altering drug pharmacokinetics at both the whole organism and subcellular level leading to improved therapeutic outcomes. However, the failure of many polymer-drug conjugates in clinical trials suggests that we may need to stratify patients in order to match each patient to the right PT. In this concise review, we hope to assess potential PT-specific biomarkers for cancer treatment, with a focus on new studies, detection methods, new models and the opportunities this knowledge will bring for the development of novel PT-based anti-cancer strategies. We discuss the various “hurdles” that a given PT faces on its passage from the syringe to the tumor (and beyond), including the passage through the bloodstream, tumor targeting, tumor uptake and the intracellular release of the active agent. However, we also discuss other relevant concepts and new considerations in the field, which we hope will provide new insight into the possible applications of PT-related biomarkers.

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“…Interestingly, for the hydroxyl group‐free PVCi layer used case, the pentacene film shows more dendritic grains and more improved grain size (above 1 µm) compared to the hydroxyl group‐existing PVP layer. This would result from the fact that the hydroxyl group produces a hydrophilic surface . Considering the fact that a hydrophobic surface usually results in large grains of organic semiconductor, it is reasonable that the larger pentacene grain is induced on the hydroxyl group‐free PVCi layer than that on the hydroxyl group‐existing PVP layer.…”

Section: Resultsmentioning

confidence: 99%

Engineered interface using a hydroxyl group‐free polymeric buffer layer onto a TiO₂ nanocomposite film for improving the electrical properties in a low‐voltage operated organic transistor

Bae

Choi

2011

Surface & Interface Analysis

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We demonstrate the effect of engineered interfaces by introducing different classes of polymeric buffer layers onto a titanium oxide (TiO 2 ) nanocomposite film on the density of interfacial trap sites and corresponding mobility in low-voltage-operated organic field-effect transistors. The organic field-effect transistors were fabricated using pentacene as an organic semiconductor layer and a high dielectric TiO 2 nanocomposite film for low-voltage operation stacked with two different kinds of thin polymers, one of which is hydroxyl group-existing polyvinyl phenol and the other is hydroxyl group-free polyvinyl cinnamate. By using the hydroxyl group-free buffer layer, the interfacial trap density is found to be much decreased than that for the hydroxyl groupexisting buffer layer. In addition, the mobility for the polyvinyl cinnamate used case, shows significantly increased value by at least one of magnitude compared to the case of no buffer layer. It is found that a hydroxyl group-free polymeric layer produces a more effective surface, which leads to high electrical properties and less electrochemical traps at the interface in the organic devices.

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The Influence of Pendant Hydroxyl Groups on Enzymatic Degradation and Drug Delivery of Amphiphilic Poly[glycidol‐block‐(ε‐caprolactone)] Copolymers

Cited by 22 publications

References 39 publications

Optimization of release pattern of FGF-2 and BMP-2 for osteogenic differentiation of low-population density hMSCs

Optimization of release pattern of FGF-2 and BMP-2 for osteogenic differentiation of low-population density hMSCs

Polymer Therapeutics: Biomarkers and New Approaches for Personalized Cancer Treatment

Engineered interface using a hydroxyl group‐free polymeric buffer layer onto a TiO₂ nanocomposite film for improving the electrical properties in a low‐voltage operated organic transistor

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The Influence of Pendant Hydroxyl Groups on Enzymatic Degradation and Drug Delivery of Amphiphilic Poly[glycidol‐block‐(ε‐caprolactone)] Copolymers

Cited by 22 publications

References 39 publications

Optimization of release pattern of FGF-2 and BMP-2 for osteogenic differentiation of low-population density hMSCs

Optimization of release pattern of FGF-2 and BMP-2 for osteogenic differentiation of low-population density hMSCs

Polymer Therapeutics: Biomarkers and New Approaches for Personalized Cancer Treatment

Engineered interface using a hydroxyl group‐free polymeric buffer layer onto a TiO2 nanocomposite film for improving the electrical properties in a low‐voltage operated organic transistor

Contact Info

Product

Resources

About

Engineered interface using a hydroxyl group‐free polymeric buffer layer onto a TiO₂ nanocomposite film for improving the electrical properties in a low‐voltage operated organic transistor