A facile surface modification strategy for fabrication of fluorescent silica nanoparticles with the aggregation-induced emission dye through surface-initiated cationic ring opening polymerization

Huang, Long; Yang, Saijiao; Chen, Junyu; Tian, Jianwen; Huang, Qiang; Huang, Hongye; Wen, Yuanqing; Deng, Fengjie; Zhang, Xiaoyong; Wei, Yen

doi:10.1016/j.msec.2018.09.042

Cited by 93 publications

(15 citation statements)

References 68 publications

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“…Several drug delivery systems, such as lipid emulsions, nanoparticles, and liposomes, have been employed to promote the solubility, pharmacological activity, and bioavailability of BF [10, 11]. Moreover, the aggregation-induced emission (AIE) active functional polymeric self-assemblies have showed great potential for various biomedical applications including biological imaging and intracellular drug delivery [12, 13]. Among these drug delivery systems, liposomal preparations have several advantages for use as intravenous (i.v.)…”

Section: Introductionmentioning

confidence: 99%

Bufalin-Loaded PEGylated Liposomes: Antitumor Efficacy, Acute Toxicity, and Tissue Distribution

et al. 2019

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Bufalin, derived from Venenum Bufonis , exerts antitumor effects but has low bioavailability and adverse effects when administered as a single agent. The purpose of this study was to evaluate the physical and chemical properties, antitumor efficacy, general pharmacology, acute toxicity, and tissue distribution profile of bufalin-loaded PEGylated liposomes (BF/PEG-LP), which were prepared in a previous study. To evaluate the safety of the preparation, a red blood cell hemolysis test was performed, which indicated that the hemolysis rate of BF/PEG-LP was significantly lower than that of bufalin alone. Cell viability assay revealed that the blank liposomes were nontoxic. In an in vitro experiment, BF/PEG-LP dose-dependently induced the apoptosis of HepG2, HCT116, A549, and U251 cancer cells, with half-maximal inhibitory concentration (IC 50 ) values of 21.40 ± 2.39, 21.00 ± 3.34, 43.39 ± 6.43, and 31.14 ± 2.58 ng/mL, respectively, at 24 h. Tumor xenograft experiments in nude mice showed that BF/PEG-LP significantly inhibited the growth of U251 cells. Pharmacological evaluation revealed that BF/PEG-LP impacted the general behavior, independent activities, and coordination of mice after a week of administration compared with those of mice in the control group. In an acute toxicity test, the median lethal concentration (LD 50 ) of BF and BF/PEG-LP in mice was 0.156 and 3.03 mg/kg, respectively. Tissue distribution profiles showed that the BF concentration in brain tissue was 20% higher, whereas that in heart tissue was 30% lower when BF/PEG-LP was administered to mice compared with BF. Thus, BF/PEG-LP exhibited lower hemolysis and cytotoxicity and improved pharmacokinetic and antitumor properties compared with bufalin alone, indicating its potential for future pharmacological application, particularly for glioma treatment. Electronic supplementary material The online version of this article (10.1186/s11671-019-3057-0) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Bufalin-Loaded PEGylated Liposomes: Antitumor Efficacy, Acute Toxicity, and Tissue Distribution

et al. 2019

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“…[ 127–130 ] Using novel strategies to prepare polymer nanoparticles with unique structures and desirable properties has potential theory significance and industrial application. [ 131,132 ] To our knowledge, different covalent methods such as Schiff base reaction, [ 133 ] emulsion polymerization, [ 32 ] ring‐opening reaction, [ 129 ] and free radical polymerization [ 134 ] have been widely studied to produce desirable AIE polymers with different functional groups in the last few years. Tandem polymerizations, featured with high creation efficiency and convenience, have proved their potential in preparation of macromolecules with π‐conjugated structures in a one‐step way.…”

Section: Fabrication Of Fluorescent Copolymers With Aie Feature Throumentioning

confidence: 99%

Recent Advances on Fabrication of Polymeric Composites Based on Multicomponent Reactions for Bioimaging and Environmental Pollutant Removal

Yang

Liang

et al. 2021

Macromol. Rapid Commun.

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As the core of polymer chemistry, manufacture of functional polymers is one of research hotspots over the past several decades. Various polymers are developed for diverse applications due to their tunable structures and unique properties. However, traditional step‐by‐step preparation strategies inevitably involve some problems, such as separation, purification, and time‐consuming. The multicomponent reactions (MCRs) are emerging as environmentally benign synthetic strategies to construct multifunctional polymers or composites with pendant groups and designed structures because of their features, such as efficient, fast, green, and atom economy. This mini review summarizes the latest advances about fabrication of multifunctional fluorescent polymers or adsorptive polymeric composites through different MCRs, including Kabachnik–Fields reaction, Biginelli reaction, mercaptoacetic acid locking imine reaction, Debus–Radziszewski reaction, and Mannich reaction. The potential applications of these polymeric composites in biomedical and environmental remediation are also highlighted. It is expected that this mini‐review will promote the development preparation and applications of functional polymers through MCRs.

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“…148 These properties allow improving the LOD and even enabling single molecule detection, making fluorescence-based nanobiosensor devices more sensitive and reliable when compared to the classic fluorescence detection methodologies. Fluorescent NPs include NPs made with silica and organically modified silica, 149 metals, 150 metal oxides, 151 metal nanoclusters, 152,153 upconversion NPs (UCNPs), 154,155 organic polymers, 156 quantum dots (QDs), 157,158 silicon quantum dots 159 and different carbonaceous nanomaterials such as carbon dots, carbon nanotubes, carbon nanoclusters and nanodiamonds. 160,161 Lanthanide-doped UCNPs undergo a non-linear photophysical process whereby low-energy radiation, usually in the near infrared (NIR) range, is converted to higher-energy radiation, for example, visible light (anti-Stokes shift).…”

Section: Np-based Biosensors For Ev Analysismentioning

confidence: 99%

Nanoparticle-based biosensors for detection of extracellular vesicles in liquid biopsies

et al. 2020

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A facile surface modification strategy for fabrication of fluorescent silica nanoparticles with the aggregation-induced emission dye through surface-initiated cationic ring opening polymerization

Cited by 93 publications

References 68 publications

Bufalin-Loaded PEGylated Liposomes: Antitumor Efficacy, Acute Toxicity, and Tissue Distribution

Bufalin-Loaded PEGylated Liposomes: Antitumor Efficacy, Acute Toxicity, and Tissue Distribution

Recent Advances on Fabrication of Polymeric Composites Based on Multicomponent Reactions for Bioimaging and Environmental Pollutant Removal

Nanoparticle-based biosensors for detection of extracellular vesicles in liquid biopsies

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