A facile synthesis method of hydroxyethyl cellulose-silver nanoparticle scaffolds for skin tissue engineering applications

Abstract

Green porous and ecofriendly scaffolds have been considered as one of the potent candidates for tissue engineering substitutes. The objective of this study is to investigate the biocompatibility of hydroxyethyl cellulose (HEC)/silver nanoparticles (AgNPs), prepared by the green synthesis method as a potential host material for skin tissue applications . The substrates which contained varied concentrations of AgNO (0.4%-1.6%) were formed in the presence of HEC, were dissolved in a single step in water. The presence of AgNPs was confirmed visually by the change of color from colorless to dark brown, and was fabricated via freeze-drying technique. The outcomes exhibited significant porosity of > 80%, moderate degradation rate, and tremendous value of water absorption up to 1163% in all samples. These scaffolds of HEC/AgNPs were further characterized by SEM, UV-Vis, ATR -FTIR, TGA, and DSC.

New Nanotechnologies for the Treatment and Repair of Skin Burns Infections

“…Study of the incorporation of silver nanoparticles on the surface of a natural biomaterial of collagens type I, V and X (eggshell membrane) using polydopamine mediated adhesion and reduction properties, which exhibited benefits for tissue regeneration, biocompatibility and low toxicity. Zulkifli et al developed a hydroxyethyl cellulose-silver nanoparticle (HEC-AgNP) lyophilized scaffold [106]. In this study, hydroxyethyl cellulose serves as a polymer matrix and a reducing agent of silver ions to a zero-valent form and nanoparticle formation using freeze-dry methodology.…”

“…In this study, hydroxyethyl cellulose serves as a polymer matrix and a reducing agent of silver ions to a zero-valent form and nanoparticle formation using freeze-dry methodology. When in contact with moisture or wound fluid, silver ions are released, inhibiting bacterial growth, without toxicity effects on human fibroblast cell growth [106].…”

“…[99] Hydroxyethyl cellulose-silver nanoparticle (HEC-AgNP) lyophilized scaffold Silver nanoparticles Development of a hydroxyethyl cellulose-silver nanoparticle (HEC-AgNP) lyophilized scaffold, using freeze-dry methodology. [106] Polydopamine and collagens type I, V, X eggshell membrane loaded with silver nanoparticles…”

A review of using green chemistry methods for biomaterials in tissue engineering

“…This is a safe and easy method for preparing AgNPs through in situ mechanism. 38 Bacterial cellulose is another great candidate with efficient ability in biomedical applications such as biodegradability, network structure, high mechanical strength, good water absorption capacity, easy preparation, structure like to plant cellulose, and ability for modifying. However, it still lacks some desirable properties especially for the application in tissue engineering, due to insufficient porosity structure and low biodegradability in the body organs, which limits its application in medicine.…”

A green deposition method of silver nanoparticles on textiles and their antifungal activity

“…However, the use of chemicals can threaten the health of the skin and the environment due to their toxic characteristics [18]. In the application of AgNPs as wound healing, physically or chemically induced cutaneous wounds may significantly disturb skin structural and functional integrity at different stages, leading to permanent disability or even death, depending on the severity of the injury [19]. It indicates a need to propose a new green deposition method of AgNPs on textiles without the use of binders or other chemical compounds for the stabilization.…”