A Facile Synthesis of 4(3H)-Pteridinone Derivatives by Utilizing N-{3-[(N-Substituted)carbamoyl]-2-pyrazyl}iminophosphoranes

Abstract

The intermolecular aza-Wittig reaction of iminophosphoranes 4 derived from 3-aminopyrazine-2-( N -substituted)-carboxamide derivatives 2 with various acyl chlorides followed by heterocyclization provided an efficient synthetic route to 2,3-disubstituted 4(3 H )-pteridinone derivatives 5 .