A facile synthesis of flavones catalysed by gallium(III) triflate

Jin, Can; He, Fei; Wu, Huayue; Chen, Jiuxi; Su, Weike

doi:10.3184/030823409x396409

Cited by 10 publications

(1 citation statement)

References 25 publications

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“…Lewis acid catalysis in flavone synthesis was demonstrated in Su’s work. Di-carbonyl compounds 104 were annulated efficiently in the correspondent flavones 105 in the presence of Ga(OTf) 3 as a mild promoter ( Scheme 44 ) [ 106 ].…”

Section: Quercetin and Luteolinmentioning

confidence: 99%

Metal-Promoted Heterocyclization: A Heterosynthetic Approach to Face a Pandemic Crisis

2021

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The outbreak of SARS-CoV-2 has drastically changed our everyday life and the life of scientists from all over the world. In the last year, the scientific community has faced this worldwide threat using any tool available in order to find an effective response. The recent formulation, production, and ongoing administration of vaccines represent a starting point in the battle against SARS-CoV-2, but they cannot be the only aid available. In this regard, the use of drugs capable to mitigate and fight the virus is a crucial aspect of the pharmacological strategy. Among the plethora of approved drugs, a consistent element is a heterocyclic framework inside its skeleton. Heterocycles have played a pivotal role for decades in the pharmaceutical industry due to their high bioactivity derived from anticancer, antiviral, and anti-inflammatory capabilities. In this context, the development of new performing and sustainable synthetic strategies to obtain heterocyclic molecules has become a key focus of scientists. In this review, we present the recent trends in metal-promoted heterocyclization, and we focus our attention on the construction of heterocycles associated with the skeleton of drugs targeting SARS-CoV-2 coronavirus.

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Section: Quercetin and Luteolinmentioning

confidence: 99%

Metal-Promoted Heterocyclization: A Heterosynthetic Approach to Face a Pandemic Crisis

2021

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Gold Nanoparticles Supported on a Layered Double Hydroxide as Efficient Catalysts for the One‐Pot Synthesis of Flavones

et al. 2015

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Flavones are aclass of natural products with diverse biological activities and have frequently been synthesized by step-by-step procedures using stoichiometric amounts of reagents.Herein, acatalytic one-pot procedure for the synthesis of flavone and its derivatives is developed. In the presence of gold nanoparticles supported on aM g-Al layered double hydroxide (Au/LDH), various kinds of flavones can be synthesized starting from 2'-hydroxyacetophenones and benzaldehydes (or benzyl alcohols). The present one-pot procedure consists of asequence of several reactions,and Au/LDH can catalyze all these different types of reactions.The catalysis is shown to be truly heterogeneous,a nd Au/LDH can be readily recovered and reused.

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Gold Nanoparticles Supported on a Layered Double Hydroxide as Efficient Catalysts for the One‐Pot Synthesis of Flavones

et al. 2015

View full text Add to dashboard Cite

Flavones are a class of natural products with diverse biological activities and have frequently been synthesized by step-by-step procedures using stoichiometric amounts of reagents. Herein, a catalytic one-pot procedure for the synthesis of flavone and its derivatives is developed. In the presence of gold nanoparticles supported on a Mg-Al layered double hydroxide (Au/LDH), various kinds of flavones can be synthesized starting from 2'-hydroxyacetophenones and benzaldehydes (or benzyl alcohols). The present one-pot procedure consists of a sequence of several reactions, and Au/LDH can catalyze all these different types of reactions. The catalysis is shown to be truly heterogeneous, and Au/LDH can be readily recovered and reused.

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A facile synthesis of flavones catalysed by gallium(III) triflate

Abstract: Ga(OTf) 3 was explored as a novel catalyst for the cyclisation of 1-(2-hydroxyphenyl)-3-aryl-1,3-propanediones in nitromethane to flavones with excellent yields.

Cited by 10 publications

References 25 publications

Metal-Promoted Heterocyclization: A Heterosynthetic Approach to Face a Pandemic Crisis

Metal-Promoted Heterocyclization: A Heterosynthetic Approach to Face a Pandemic Crisis

Gold Nanoparticles Supported on a Layered Double Hydroxide as Efficient Catalysts for the One‐Pot Synthesis of Flavones

Gold Nanoparticles Supported on a Layered Double Hydroxide as Efficient Catalysts for the One‐Pot Synthesis of Flavones

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