A Familial Cluster of Human Brucellosis Attributable to Contact with Imported Infected Goats in Shuyang, Jiangsu Province, China, 2013

Tan, Zhongming; Huang, Yong; Liu, Genyan; Zhou, Wei-Zhong; Xu, X N; Zhang, Zibing; Shen, Qing; Tang, Fenyang; Zhu, Yefei

doi:10.4269/ajtmh.15-0149

Cited by 20 publications

(15 citation statements)

References 11 publications

(7 reference statements)

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“…Hence persons engaged in livestock husbandry, production, and trade are at high risk for brucellosis infection because of occupational exposure. Additionally, animal products supplied from brucellosis-endemic areas that have not undergone quarantine or pasteurization might increase the risk for infection in nonoccupational populations and urban settings, taking a longer time from illness to diagnosis for imported cases in southern China, which might create extra challenges for disease prevention and case management ( 19 , 20 , 40 ). Therefore, susceptible livestock animals as the host and infection source for human infections are key to brucellosis prevention and control.…”

Section: Discussionmentioning

confidence: 99%

“…During the past decade, outbreaks of human brucellosis have been reported in increasing numbers and with an apparent geographic expansion from the historically affected north of China ( 17 , 18 ) to southern provinces where nonoccupational exposure might be more common because of the increasing movement of humans, animals, and animal food products from brucellosis-endemic regions ( 19 – 21 ). The epidemiology of human brucellosis clearly presented major challenges in China during the past 60 years, but studies reporting the spatial–temporal patterns of human brucellosis with high-quality, nationwide incidence data are lacking ( 2 , 4 , 14 , 22 , 23 ).…”

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confidence: 99%

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Changing Epidemiology of Human Brucellosis, China, 1955–2014

Lai¹,

Zhou²,

Xiong³

et al. 2017

Emerg. Infect. Dis.

196

189

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Brucellosis, a zoonotic disease, was made statutorily notifiable in China in 1955. We analyzed the incidence and spatial–temporal distribution of human brucellosis during 1955–2014 in China using notifiable surveillance data: aggregated data for 1955–2003 and individual case data for 2004–2014. A total of 513,034 brucellosis cases were recorded, of which 99.3% were reported in northern China during 1955–2014, and 69.1% (258, 462/374, 141) occurred during February–July in 1990–2014. Incidence remained high during 1955–1978 (interquartile range 0.42–1.0 cases/100,000 residents), then decreased dramatically in 1979–1994. However, brucellosis has reemerged since 1995 (interquartile range 0.11–0.23 in 1995–2003 and 1.48–2.89 in 2004–2014); the historical high occurred in 2014, and the affected area expanded from northern pastureland provinces to the adjacent grassland and agricultural areas, then to southern coastal and southwestern areas. Control strategies in China should be adjusted to account for these changes by adopting a One Health approach.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Changing Epidemiology of Human Brucellosis, China, 1955–2014

Lai¹,

Zhou²,

Xiong³

et al. 2017

Emerg. Infect. Dis.

196

189

View full text Add to dashboard Cite

show abstract

“…The number of livestock increased significantly in the past decade to meet the growing demands for meat consumption in mainland China [ 8 ], which would give rise to the increase of the total population of infected domestic animals, even with relatively low-level seroprevalence in livestock. Lack of quarantine or pasteurization in the livestock product supply also increased the risk of infections in non-occupational populations and urban settings [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Trends of reported human brucellosis cases in mainland China from 2007 to 2017: an exponential smoothing time series analysis

Guan

Huang

2018

Environ Health Prev Med

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BackgroundThe main objective of this study was to describe the temporal distribution of monthly reported human brucellosis cases in mainland China and develop an appropriate time series model for short-term extrapolation forecast.MethodsSurveillance data of the monthly reported human brucellosis cases occurring from April 1, 2007, to March 31, 2017, in mainland China were obtained. The spectrum analysis was first adopted to find the cyclic and seasonal features, the existence of the seasonality and trend was determined by exponential smoothing method and the seasonal-trend decomposition. The candidate models of exponential smoothing included the additive model and multiplicative model; R2 was selected as the indicator for the selection of candidate model, and the stability of the model was verified by adjusting the training data and test data set. Finally, the extrapolations of monthly incident human brucellosis cases in 2017 were made.ResultsFrom April 1, 2007, to March 31, 2017, a total of 435,108 cases of Brucellosis occurred in mainland China were reported, with an average of 3626 cases per month and a standard deviation of 1834 cases. The R2 of the exponential smoothing method that based on additive model increased steadily from 0.927 to 0.949 with the increase of the data volume. Ten of 12 actual values fell in the confidence interval of predicted value.ConclusionsHuman brucellosis cases peaked during the months from March to August in mainland China, with clear seasonality. The exponential smoothing based on the additive model method could be effectively used in the time series analysis of human brucellosis in China. Control methods, such as vaccination, quarantine, elimination of infected animals, and good hygiene within the production cycle, should be strengthened with paying more attention to the seasonality. Further research is warranted to explore the drivers behind the seasonality.

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“…However, animal brucellosis has re‐emerged in recent years due to the convenient transportation of animals coupled with the neglect of prevention and control measures. Moreover, human cases have been observed in regions where animal farming is prevalent, particularly in areas with many poor rural farms and pastures in northwest China (Hou et al., ; Moreno, ; Tan et al., ). Therefore, clarification of the molecular features of Brucella epidemic isolates will play a vital role in vaccination programmes and animal epidemic prevention.…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, brucellosis has re‐emerged in China (Chen et al., ; Chuang et al., ; Hou et al., ). Due to the ease of transporting animals and lack of control measure implementation by the government, brucellosis outbreaks have occurred in northwest China, resulting in zoonotic spillover to humans (Chen et al., ; Tan et al., ; Zhang et al., ).…”

Section: Introductionmentioning

confidence: 99%

Molecular epidemiological characterization ofBrucellaisolates from sheep and yaks in northwest China

Cao

Liu

et al. 2017

Transbound Emerg Dis

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Animal brucellosis is a re-emerging disease in China with high prevalence in the northwest region. A total of 66 isolates of Brucella were recovered from sheep and yaks in the Inner Mongolia, Xinjiang, Qinghai and Gansu provinces of northwest China in 2015 and 2016. Using classical biotyping and the Brucella AMOS PCR assay, all isolates were identified as Brucella melitensis biovar 3 (n = 58), B. melitensis biovar 1 (n = 1), Brucella abortus (n = 5), or Brucella suis biovar 3 (n = 2), and B. melitensis biovar 3 was found to be mainly responsible for sheep brucellosis in northwest China. Multilocus variable-number tandem-repeat analysis (MLVA) was used to identify the epidemiological relationships among the isolates and to assess their genetic diversity. Multilocus variable-number tandem-repeat analysis-16 identified 46 genotypes in these populations, including 37 unique and nine shared genotypes. Multilocus variable-number tandem-repeat analysis-11 showed that 71% of the isolates (47 of 66) were genotype 116 (1-5-3-13-2-2-3-2-4-41-8), a characteristic subgroup of the East Mediterranean group, showing that isolates from different geographical areas exhibit similar epidemiological characteristics in different regions and may be epidemiologically linked. Multilocus variable-number tandem-repeat analysis-11 also revealed that an isolate from Inner Mongolia had a novel genotype, 369 (1-5-3-13-2-2-3-2-7-41-8). Multilocus variable-number tandem-repeat analysis-16 genotyping of northwest China Brucella isolates allows a better understanding of the epidemiology of animal brucellosis in this region. This study is the first analysis of B. melitensis in Gansu province, and the results confirmed that in this province, isolates of this species are disorderly and unsystematic.

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A Familial Cluster of Human Brucellosis Attributable to Contact with Imported Infected Goats in Shuyang, Jiangsu Province, China, 2013

Cited by 20 publications

References 11 publications

Changing Epidemiology of Human Brucellosis, China, 1955–2014

Changing Epidemiology of Human Brucellosis, China, 1955–2014

Trends of reported human brucellosis cases in mainland China from 2007 to 2017: an exponential smoothing time series analysis

Molecular epidemiological characterization ofBrucellaisolates from sheep and yaks in northwest China

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