A familial outbreak of fascioliasis in Eastern Anatolia: A report with review of literature

Karahocagil, Mustafa Kasım; Akdeniz, Hayrettin; Sünnetçioğlu, Mahmut; Çiçek, Mutalip; Mete, Rafet; Akman, Nevzat; Ceylan, Erkan; Karsen, Hasan; Yapici, Kubilay

doi:10.1016/j.actatropica.2008.08.013

Cited by 37 publications

(38 citation statements)

References 26 publications

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“…Numerous studies demonstrated that in many infectious diseases, a variety of inflammatory cells are activated, which lead to production of reactive oxygen and nitrogen species to kill parasites. 20,21 One of theparasites which inhabits in hepatic bile ducts is F. hepatica and causes the disease 22 . In order to investigate the effect of F. hepatica on oxidative status, we measured TAC, TOS, OSI and catalase.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of oxidative status in patients with <i>Fasciola hepatica</i> infection

Karsen

Sünnetçioğlu²,

Ceylan³

et al. 2011

Af Hlth Sci

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AbsractBackground: F. hepatica infection is rare and mostly subclinical. Migration of juvenile forms of F. hepatica into the host's liver is accompanied by an inflammatory reaction followed by fibrosis and cirrhosis. Objective: The aim of this study was to evaluate oxidative status by using a novel automated method in patients with Fasciola hepatica. Methods: Twenty two patients with a diagnosis of F. hepatica and 26 healthy volunteers were enrolled in the study. Their Total antioxidant capacity status (TAC), total oxidant status (TOS) and catalase were measured in them and oxidative stress index (OSI) was calculated. These measurements were also taken for the control group and the values were compared. Results: Plasma levels of total TOS and OSI were significantly increased in patients as compared with healthy controls (P<0.001, P<0.001, P=0.001, P=0.008) respectively. In contrast, TAC level was significantly lower in patients as compared with controls (p<0.05). There was no significant difference between the catalase results of the two groups (p>0.05). Conclusion: Total oxidative status and OSI were increased and total antioxidative status capacity was decreased in patients with F. hepatica infeciton. A high oxidative stress occurs during F. hepatica infection, which may cause severe damage in both the liver.

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Section: Discussionmentioning

confidence: 99%

Evaluation of oxidative status in patients with <i>Fasciola hepatica</i> infection

Karsen

Sünnetçioğlu²,

Ceylan³

et al. 2011

Af Hlth Sci

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“…The parasites which cause tissue invasion may result in extreme eosinophilia 12 . It is reported that the most common laboratory abnormalities of fascioliasis are the increased levels of total IgE, total IgG, leukocytosis and eosinophilia elevations in the erythrocyte sedimentation rate (ESR) 6,7 . Eosinophil count is variable in fascioliasis patients, particularly higher in acute cases 3,7,13 .…”

Section: Discussionmentioning

confidence: 99%

“…However, if the symptoms last for >4 months in conjunction with positive biliary ultrasound findings, the patient should be considered as chronic 7 . Our patient was diagnosed as acute fascioliasis since he had severe abdominal pain, fever and weight loss for one month and also had marked eosinophilia and history of consuming watercres.…”

Section: Discussionmentioning

confidence: 99%

“…A Pediatric Case of Fascioliasis geographic hypoechoic nodules with irregular and poorly-defined margins and these nodules have peripheral and subcapsular localization, generally around the biliary tract in the liver, whereas the second type is tunnel-like branching spaces, which are also peripherally located and caused by parasite migration 7,13,14 . It was reported that, USG may not be diagnostic in the hepatic phase secondary to heterogeneity of the liver because of the poorly defined nodules; it is more useful in the biliary stage of the disease 15 .…”

Section: Volume 58 • Numbermentioning

confidence: 99%

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A pediatric case of Fascioliasis with eosinophilic pneumonia

et al. 2016

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Fasciolia spp. are common trematode infestations worldwide. Fasciolia spp. may lead to hepatic diseases in the acute phase and may cause biliary diseases in the chronic phase. In addition, Fasciolia spp. may rarely cause extrahepatic signs and symptoms. The clinical manifestations of fascioliasis are divided into three groups: typical, atypical, and ectopic. Eosinophilic pneumonia is an atypical presentation of acute fascioliasis and it has been reported very rarely. Herein, we report a boy with marked blood eosinophilia and eosinophilic pneumonia who was diagnosed with fascioliasis by serologic tests and abdominal USG. The patient recovered completely following triclabendazole treatment. Key words: fascioliasis, eosinophilic pneumonia, eosinophilic leukemoid reac tion, child.Fascioliasis is a zoonotic foodborne trematode infection caused by Fasciola spp. which are flat leaf-like worms known as liver flukes. The two species that infect humans are Fasciola hepatica and Fasciola gigantica 1 . Other most prominent liver flukes are Clonorchis sinensis, Opisthorchis felineus and Opisthorchis viverrini 2 . World Health Organization estimates that at least 2.4 million people are infected with fascioliasis in more than 70 countries worldwide, with several million at risk. Fasciolia spp. have worldwide distribution and not only animal cases but also human cases have been reported 1,2 . Humans are infected by ingestion of watercress, salad vegetables, and water which are contaminated with metacercariae 1,3 . Clinical spectrum of the infection is variable; however, fascioliasis cases with lung involvement are very rare. Herein, we report a rare presentation of eosinophilic pneumonia accompanied by eosinophilic leukemoid reaction in the course of fascioliasis. Case ReportA 4-year-old boy presented with a one-month history of abdominal pain, poor appetite, and occasional fever. He had lost one kilo in the last one month and had no history of worm defecation. Physical examination was normal and the laboratory studies revealed peripheral blood leukocyte count 32,300/ mm 3 ; hemoglobin 10.9 g/dl; platelet count 29,000/mm 3 ; C-reactive protein (CRP) level 5.7 mg/L; erythrocyte sedimentation rate 32 mm/h with 64% eosinophils, 18% lymphocytes, 2% monocytes, and 16% polymorphonuclear leukocytes. Total immunoglobulin E level was 906 IU/mL (0-5) and the Ig G level was normal. Renal and hepatic function tests were normal. The patient had severe eosinophilia (absolute eosinophil count was 20,672/mm 3 ) and was admitted to the hospital for the investigation of the etiology of eosinophilic leukemoid reaction. Parasite stool tests by "formalin ether sedimentation" and "saturated sodium chloride flotation" methods were negative three times. Echinococcus granulosus indirect hemagglutination assay (IHA) was negative but Fasciola hepatica IHA, which was repeated twice, was positive at a titer of 1/640. Toxocara IgG ELISA was slightly positive (0.539; range, 0-0.500) at the beginning since second repetition was negative, it was considered as ...

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“…Previous studies have suggested an association of fascioliasis with anemia and nutritional deficiencies, which could cause irreversible developmental deficits. [7][8][9][10] Hyperendemic areas (prevalence 10%) for fascioliasis have been described throughout the Peruvian highlands. 11,12 A risk factor for Fasciola transmission recognized in a casecontrol study in children from the Peruvian Altiplano is the consumption of raw vegetables (alfalfa juice).…”

Section: Introductionmentioning

confidence: 99%

Fascioliasis and Eosinophilia in the Highlands of Cuzco, Peru and Their Association with Water and Socioeconomic Factors

Cabada¹,

Goodrich²,

Graham³

et al. 2014

The American Society of Tropical Medicine and Hygiene

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Abstract. There are limited data about the epidemiology of fascioliasis in Cuzco, Peru. We studied children 3-12 years old from six communities in the highlands of Cuzco to evaluate the epidemiology of fascioliasis; 227 children were included, one-half were female, the mean age was 7.5 (±2.6) years, and 46.2±% had one or more parasites, including Fasciola (9.7%), Ascaris (12.8%), Hymenolepis (9.3%), Trichuris (1.3%), hookworm (1.8%), Strongyloides (0.9%), and Giardia (27.8%). Fasciola was associated with the number of siblings in the household, drinking untreated water, and giardiasis. Eosinophilia was encountered in 21% of children and more common in those drinking untreated water at home and those infected with a parasite, but the differences were not significant. Eating water plants was not associated with Fasciola or eosinophilia. Fascioliasis and eosinophilia were common in the highlands of Cuzco. Fascioliasis was associated with socioeconomic factors and drinking water. BACKGROUND

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A familial outbreak of fascioliasis in Eastern Anatolia: A report with review of literature

Cited by 37 publications

References 26 publications

Evaluation of oxidative status in patients with <i>Fasciola hepatica</i> infection

Evaluation of oxidative status in patients with <i>Fasciola hepatica</i> infection

A pediatric case of Fascioliasis with eosinophilic pneumonia

Fascioliasis and Eosinophilia in the Highlands of Cuzco, Peru and Their Association with Water and Socioeconomic Factors

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