A fast and label-free detection of hydroxymethylated DNA using a nozzle-jet printed AuNPs@Ti3C2 MXene-based electrochemical sensor

Bhat, Kiesar Sideeq; Byun, Seongjun; Alam, Asrar; Ko, Myunggon; An, Jeong Ho; Lim, Sooman

doi:10.1016/j.talanta.2022.123421

Cited by 25 publications

(8 citation statements)

References 65 publications

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“…Figure S6 of the Supplementary Materials shows the effect of the scan rate varied from 10 to 100 mV s −1 in the presence of 1 mM glucose in PBS. From the result, the scan rate is increased and the glucose oxidation peak current also increases, due to its diffusion-controlled (1.75 × 10 −6 cm −1 ) oxidation of glucose to gluconolactone [ 35 , 36 , 37 , 38 , 39 , 40 ]. Next, the effect of the pH on the ZnO–g–Ru–C 3 N 4 modified electrode in the presences of 1 mM glucose oxidation peak current and peak potential was carefully monitored by CV using 100 mM PBS in different pH ranging (5, 5.5, 6, 7, 7.4, 8 and 8.5) at a scan rate 50 mV s −1 in Figure 4 .…”

Section: Resultsmentioning

confidence: 99%

Fabrication of Enzyme-Free and Rapid Electrochemical Detection of Glucose Sensor Based on ZnO Rod and Ru Doped Carbon Nitride Modified Gold Transducer

et al. 2022

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Over 3 in 4 adults with diabetes live in low- and middle-income counties and health expenditure also increased 316% over the last 15 years. In this regard, we fabricate low cost, reusable and rapid detection of diabetes sensor based on zinc oxide rod inserted ruthenium-doped carbon nitride (ZnO–g–Ru–C3N4) modified sensor device. Developed sensor device physically and electrochemically characterized using X-ray diffraction (XRD), fourier-transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), cyclic voltammetry (CV), chronoamperometry (CA) and differential pulse voltammetry (DPV). Sensing device as an effective enzyme-free glucose detection with high sensitivity (346 μA/mM/cm2) over the applied lower potential of +0.26 V (vs. Ag/AgCl), fast response (3 s) and broad linear range of (2–28) mM, coupled with a lower limit of detection (3.5 nM). The biosensing device gives better anti-interference ability with justifiable reproducibility, reusability (single electrode re-use 26 times in physiological buffer and 3 times in serum) and stability. Moreover, the real-time applicability of the sensor device was evaluated in human blood, serum and urine samples.

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Section: Resultsmentioning

confidence: 99%

Fabrication of Enzyme-Free and Rapid Electrochemical Detection of Glucose Sensor Based on ZnO Rod and Ru Doped Carbon Nitride Modified Gold Transducer

et al. 2022

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“…DNA hydroxymethylation (5hmC) is a type of epigenetic change in cancer cells, a new diagnostic target of cancer epigenetics research. [ 361 ] Bhat et al., [ 362 ] recently developed an innovative and label‐free detection of 5hmC in cancer cells using nozzle‐jet printed Au@MXene‐based electrochemical sensors. For this, the Au/MXene nanocomposite ink was deposited onto an Ag‐printed matrix on a polyethylene terephthalate (PET) substrate ( Figure a(i‐iv)).…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Section: Biomedical Applicationsmentioning

confidence: 99%

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3D Printable Hydrogel Bioelectronic Interfaces for Healthcare Monitoring and Disease Diagnosis: Materials, Design Strategies, and Applications

Dutta,

Ganguly,

Randhawa

et al. 2024

Adv Materials Technologies

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In recent years, additive manufacturing tools, such as 3D printing, has gained enormous attention in biomedical engineering for developing ionotropic devices, flexible electronics, skin‐electronic interfaces, and wearable sensors with extremely high precision and sensing accuracy. Such printed bioelectronics are innovative and can be used as multi‐stimuli response platforms for human health monitoring and disease diagnosis. This review systematically discusses the past, present, and future of the various printable and stretchable soft bioelectronics for precision medicine. The potential of various naturally and chemically derived conductive biopolymer inks and their nanocomposites with tunable physico‐chemical properties is also highlighted, which is crucial for bioelectronics fabrication. Then, the design strategies of various printable sensors for human body sensing are summarized. In conclusion, the perspectives on the future advanced bioelectronics are described, which will be helpful, particularly in the field of nano/biomedicine. An in‐depth knowledge of materials design to functional aspects of printable bioelectronics is demonstrated, with an aim to accelerate the development of next‐generation wearables.

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“…5-hydroxymethylcytosine (5hmc) is the epigenetic cancer biomarker in the mammalian genome. Bhat et al [328] reported a nozzle-jet printed biosensor using AuNPs@Ti 3 C 2 nanocomposite for the sensing of 5hmc in the genome. The immobilized AuNPs have shown a different affinity toward 5-methylcytosine (5 mC) and 5hmc to generate a dissimilar response.…”

Section: Immunoassay Biosensingmentioning

confidence: 99%

2D MXene‐Based Biosensing: A Review

Amara

Hussain

Ahmad

et al. 2022

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MXene emerged as decent 2D material and has been exploited for numerous applications in the last decade. The remunerations of the ideal metallic conductivity, optical absorbance, mechanical stability, higher heterogeneous electron transfer rate, and good redox capability have made MXene a potential candidate for biosensing applications. The hydrophilic nature, biocompatibility, antifouling, and anti‐toxicity properties have opened avenues for MXene to perform in vitro and in vivo analysis. In this review, the concept, operating principle, detailed mechanism, and characteristic properties are comprehensively assessed and compiled along with breakthroughs in MXene fabrication and conjugation strategies for the development of unique electrochemical and optical biosensors. Further, the current challenges are summarized and suggested future aspects. This review article is believed to shed some light on the development of MXene for biosensing and will open new opportunities for the future advanced translational application of MXene bioassays.

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A fast and label-free detection of hydroxymethylated DNA using a nozzle-jet printed AuNPs@Ti3C2 MXene-based electrochemical sensor

Cited by 25 publications

References 65 publications

Fabrication of Enzyme-Free and Rapid Electrochemical Detection of Glucose Sensor Based on ZnO Rod and Ru Doped Carbon Nitride Modified Gold Transducer

Fabrication of Enzyme-Free and Rapid Electrochemical Detection of Glucose Sensor Based on ZnO Rod and Ru Doped Carbon Nitride Modified Gold Transducer

3D Printable Hydrogel Bioelectronic Interfaces for Healthcare Monitoring and Disease Diagnosis: Materials, Design Strategies, and Applications

2D MXene‐Based Biosensing: A Review

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