A fast passive and planar liquid sample micromixer

Melin, Jessica; Giménez, Guillem; Roxhed, Niclas; Wijngaart, Wouter van der; Stemme, G.

doi:10.1039/b314080f

Cited by 75 publications

(56 citation statements)

References 16 publications

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“…While other researches have developed static Y-junction microvalves to catch and hold liquid streams using surface tension against tapered channel walls, samples may only be released when an adjacent fluid stream overcomes surface tension and subsequently combines with the sample. 29,30 Other static resistance features exist for catching samples in microfluidic serial processes using hydrophobic patches, 15 or temperature control methods. 31 However, latches are the most aptly suited alignment mechanism for our application.…”

Section: Microfluidic Latchmentioning

confidence: 99%

Digital microfluidics using soft lithography

et al. 2006

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Although microfluidic chips have demonstrated basic functionality for single applications, performing varied and complex experiments on a single device is still technically challenging. While many groups have implemented control software to drive the pumps, valves, and electrodes used to manipulate fluids in microfluidic devices, a new level of programmability is needed for end users to orchestrate their own unique experiments on a given device. This paper presents an approach for programmable and scalable control of discrete fluid samples in a polydimethylsiloxane (PDMS) microfluidic system using multiphase flows. An immiscible fluid phase is utilized to separate aqueous samples from one another, and a novel ''microfluidic latch'' is used to precisely align a sample after it has been transported a long distance through the flow channels. To demonstrate the scalability of the approach, this paper introduces a ''generalpurpose'' microfluidic chip containing a rotary mixer and addressable storage cells. The system is general purpose in that all operations on the chip operate in terms of unit-sized aqueous samples; using the underlying mechanisms for sample transport and storage, additional sensors and actuators can be integrated in a scalable manner. A novel high-level software library allows users to specify experiments in terms of variables (i.e., fluids) and operations (i.e., mixes) without the need for detailed knowledge about the underlying device architecture. This research represents a first step to provide a programmable interface to the microfluidic realm, with the aim of enabling a new level of scalability and flexibility for lab-on-a-chip experiments.

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Section: Microfluidic Latchmentioning

confidence: 99%

Digital microfluidics using soft lithography

et al. 2006

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“…5. Each channel contact point can be designed as a narrow opening that functions as a geometric capillary valve (Melin, 2004) to avoid bubble trapping: if only one side of an opening is wetted, the surface energy prevents the liquid--gas interface to cross the opening. Once both sides of the opening are wetted, flow through the opening is allowed.…”

Section: Verification Of the Assumptions And Approximationsmentioning

confidence: 99%

“…Such designs have been realised in the form of parallel microchannels arranged in an arborescent pattern (Juncker, 2002) or arrays of posts (Gervais, 2011), or meshes (Mirzaei, 2010). Based on a microfluidic design by Melin et al (Melin, 2004), Safavieh et al reported a CP design with varying capillary flow based on a meandering channel design containing geometric capillary valves between the meander arms. Capillary suction when the liquid front is at position x…”

Section: Introductionmentioning

confidence: 99%

Capillary pumps with constant flow rate

Wijngaart

2014

Microfluid Nanofluid

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This paper unambiguously derives, ab initio starting from the Navier--Stokes and Laplace equations, the geometric parameters defining capillary pumps with rectangular cross--section with constant volumetric flow rate and steady velocity profile. The parametric formulation of the channel shape is derived using Taylor series approximations of the capillary pressure and the hydrodynamic flow resistance with negligible error. First, the design parameters are derived for a capillary pump consisting of a single channel and illustrated with an example. Thereafter, the design parameters for multichannel and for micropillar array capillary pumps are derived. Finally, the design of capillary pumps for multistep constant flow rates derived and those for arbitrarily varying flow rates are discussed.2

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“…Serpentine or zigzag shapes are frequently used as microchannels to increase the ratio of the channel surface area to its volume. Based on these basic designs, intersecting channels could be added to split, rearrange, and combine flow streams (He et al, 2001;Melin et al, 2004). Additionally, three-dimensional serpentine structures were developed to promote a chaotic mixing effect (Liu et al, 2000;Vijayendran et al, 2003).…”

Section: Driving and Control Of Fluidsmentioning

confidence: 99%

Applications of Microfluidics in the Agro-Food Sector: A Review

Kim¹,

Lim²,

Mo³

2016

Journal of Biosystems Engineering

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Background: Microfluidics is of considerable importance in food and agricultural industries. Microfluidics processes low volumes of fluids in channels with extremely small dimensions of tens of micrometers. It enables the miniaturization of analytical devices and reductions in cost and turnaround times. This allows automation, high-throughput analysis, and processing in food and agricultural applications. Purpose: This review aims to provide information on the applications of microfluidics in the agro-food sector to overcome limitations posed by conventional technologies. Results: Microfluidics contributes to medical diagnosis, biological analysis, drug discovery, chemical synthesis, biotechnology, gene sequencing, and ecology. Recently, the applications of microfluidics in food and agricultural industries have increased. A few examples of these applications include food safety analysis, food processing, and animal production. This study examines the fundamentals of microfluidics including fabrication, control, applications, and future trends of microfluidics in the agro-food sector. Conclusions: Future research efforts should focus on developing a small portable platform with modules for fluid handling, sample preparation, and signal detection electronics.

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A fast passive and planar liquid sample micromixer

Cited by 75 publications

References 16 publications

Digital microfluidics using soft lithography

Digital microfluidics using soft lithography

Capillary pumps with constant flow rate

Applications of Microfluidics in the Agro-Food Sector: A Review

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