Present wearable sensors are able to measure the frequency of vital signs such as respiration rate and heartbeat rate, but unable to measure those quantitatively, e.g. respiratory volume and heartbeat strength. Meanwhile, airflow at mouth contains both the respiration and the heartbeat quantitative signals. In this study, we propose a calibration method for a wearable vital sensor attached on the chest using the airflow at the mouth for quantitative respiration monitoring. An artificial ventilator and an experimental animal were introduced as test benches prior to human clinical experiment. As a proof of concept, a micro‐electro mechanical systems (MEMS) airflow sensor and a wearable accelerometer were implemented to both the test benches. The velocity output of the piston motion measured by the wearable sensor conformed with the airflow rate output, and the obtained results indicated that the wearable sensor can monitor not only the frequency of vital signs but also quantitative magnitudes such as the respiratory volume. © 2024 Institute of Electrical Engineer of Japan and Wiley Periodicals LLC.