A fatal case of viral sepsis and encephalitis in a child caused by human adenovirus type 7 infection

Zhao, Hongwei; Liu, Yingchao; Feng, Ziheng; Feng, Qin; Li, Kechun; Gao, Hengmiao; Qian, Suyun; Xu, Lili; Xie, Zhengde

doi:10.1186/s12985-022-01886-z

Cited by 11 publications

(4 citation statements)

References 13 publications

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“…Necrotic bronchitis and bronchiolitis were found in the autopsy of deceased children with HAdV pneumonia in the past, and there were a large number of typical HAdV inclusion cells and diffuse alveolar injury [14], suggesting that HAdV infection itself can cause severe pulmonary manifestations and lead to death. A case of fatal HAdV-associated encephalitis of type 7 was reported [15], whose genetic examination indicated the presence of KDR gene locus variation, which could eventually lead to the decrease of the integrity of the blood-brain barrier, thus making HAdV-associated encephalitis more likely to happen, this suggests that individual differences in the severity of nervous system involvement may also be related to host genes.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and half-year outcomes of 53 children with severe adenovirus pneumonia complicated with encephalitis or encephalopathy

Zeng,

Wei,

Liu

et al. 2023

Preprint

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The clinical characteristics and prognosis of children with human adenovirus pneumonia complicated with encephalitis or encephalopathy remain unclear. We analyzed clinical datas of 53 children who were admitted to the Respiratory Department of Children's Hospital of Chongqing Medical University in 2019 with severe adenovirus pneumonia and complicated with viral encephalitis or encephalopathy retrospectively, and 78 cases diagnosed with severe adenovirus pneumonia but without encephalitis or encephalopathy were selected as controls. Among the 53 children, 32 (60.4%) were males with a median age of 18.0(7.5-37.0) months. All of them had fever and cough, and the median fever duration was 12.0(9.5-15.0) days, 90.6%(48/53) had listlessness, 62.3%(33/53) had dysphoria, 47.2%(25/53) had hypersomnia, 13.2%(7/53) had seizure, and 30.2%(16/53) had positive signs in nervous system physical examination. The median leukocyte count of children with encephalitis or encephalopathy was 7.39 (3.53-10.73) *10^9/L, the median procalcitonin was 1.885(0.390-4.555)ng/ml, and the median lactate dehydrogenase was 980.50 (516.40-1938.00) U/L, these were significant differences compared with the control group (P values were 0.011, 0.001, 0.000), but there was no difference in nasopharyngeal adenovirus load. Children with encephalitis or encephalopathy are more likely to be complicated with leukopenia, hypoproteinemia, liver function impairment, coagulopathy, anemia, pleural effusion, abdominal effusion, hemophagocytic lymphohistiocytosis. 75.47% (40/53) of the children needed mechanical ventilation, and the rate of tracheal intubation and mechanical ventilation time were significantly increased compared with the control group (P values were 0.039, 0.000). The rates of gamma globulin, albumin and blood transfusion were 92.45% (49/53), 52.83% (28/53) and 26.42% (14/53), which were significantly higher than those in the control group (P values were 0.004, 0.000, 0.028). At the follow-up of half a year later, 35.85% (19/53) showed obliterative bronchiolitis, which was significantly higher than 11.54% (9/78) in the control group ( c2=11.098, P=0.001), and there was no obvious sequelae in the nervous system. Conclusion It is necessary to be aware of the possibility of encephalitis/encephalopathy in children with severe adenovirus pneumonia when the consciousness state changes such as listlessness. The clinical manifestations of these children are severe and the prognosis of the nervous system is not bad, but the incidence of bronchiolitis obliterans is high in the later stage.

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Section: Discussionmentioning

confidence: 99%

Clinical characteristics and half-year outcomes of 53 children with severe adenovirus pneumonia complicated with encephalitis or encephalopathy

Zeng,

Wei,

Liu

et al. 2023

Preprint

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“…Bei Säuglingen oder Immunkompromittierten kann sich eine untherapierte HSV-Konjunktivitis zu einer potenziell letalen Enzephalitis entwickeln [30]. Generell ist der Befall der Lider, aus dem sekundär eine Bindehautentzündung resultieren kann, beim Erwachsenen selten.…”

Section: Caveunclassified

Virale Bindehautentzündungen: Befunde, Therapie und Prophylaxe

Kowanz,

Rokohl,

Heindl

2023

Augenheilkunde up2date

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ZusammenfassungBesonders in den Winter- und Herbstmonaten füllen sie Augenarztpraxen und Ambulanzen von Augenkliniken: Patienten mit stark geröteten, tränenden Augen, die oftmals auch zusätzliche Allgemeinsymptome zu beklagen haben. Doch nicht jede Bindehautentzündung wird durch respiratorische Erreger mit typischer, saisonaler epidemiologischer Dynamik verursacht, bei bestimmten Erregern manifestiert sich in erster Linie ein charakteristischer Hautbefund.

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“…The human adenoviruses (HAdVs) described to date have been classified into seven species, HAdV-A through HAdV-G, that collectively comprise 52 serotypes defined by their antigenic reactivities in neutralization assays and more than 114 unique genotypes defined by genomics criteria [1] (http://hadvwg.gmu.edu, accessed on 13 January 2024). In immunocompetent hosts, depending on the infecting species and type, infections can result in a variety of illnesses including pneumonia, conjunctivitis, gastroenteritis, hepatitis, myocarditis, pharyngitis, rash, and, rarely, encephalitis [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

A Fulminant Case of Adenovirus Genotype C108 Infection in a Pediatric Stem Cell Transplant Recipient with x-Linked Lymphoproliferative Syndrome Type 1

Becken,

Lamson,

Gonzalez

et al. 2024

Viruses

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A 3-year-old male with X-linked lymphoproliferative syndrome type 1 underwent an unrelated umbilical cord blood transplant (UUCBT). The week prior to transplant the patient tested positive for adenovirus (HAdV) with a viral load of <190 copies/mL and was started on cidofovir. UUCBT proceeded as scheduled, and the patient engrafted on day +19. The patient’s HAdV load in serum continued to rise with resulting hepatic dysfunction, despite ongoing therapy with cidofovir and HAdV specific T-cell infusions. The patient died 6 months after transplantation having never cleared the virus. Next generation whole genome sequencing and sequence data analyses identified an intertypic recombinant HAdV-C P1H2F2 closely related (99.6% similarity) to genotype C108 in the isolates from three blood specimens obtained during the last week of life. Incidentally, the de novo assembly strategy enabled the detection of an adeno-associated virus type 2 (AAV2) genome in the DNA purified from the plasma isolates. Proteotyping analysis revealed minor differences in the predicted amino acid sequences for E1A, E1B 19K, E1B 55K, DNA polymerase, penton base, and fiber. None of the mutations previously described for HAdV-C5 variants resistant to cidofovir were identified. In silico restriction enzyme analysis revealed a distinct Sac I profile for the identified virus, supporting its designation as a C108 variant.

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A fatal case of viral sepsis and encephalitis in a child caused by human adenovirus type 7 infection

Cited by 11 publications

References 13 publications

Clinical characteristics and half-year outcomes of 53 children with severe adenovirus pneumonia complicated with encephalitis or encephalopathy

Clinical characteristics and half-year outcomes of 53 children with severe adenovirus pneumonia complicated with encephalitis or encephalopathy

Virale Bindehautentzündungen: Befunde, Therapie und Prophylaxe

A Fulminant Case of Adenovirus Genotype C108 Infection in a Pediatric Stem Cell Transplant Recipient with x-Linked Lymphoproliferative Syndrome Type 1

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