A fault detection and diagnosis technique for digital microfluidic biochips

Davids, D.; Joshi, Bharat; Mukherjee, Arindam; Ravindran, Arun

doi:10.1109/ims3tw.2008.4581597

Cited by 11 publications

(6 citation statements)

References 19 publications

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“…Therefore, it was difficult for a single droplet to move from source to sink consisting of very large arrays that involve thousands of electrodes. To tackle this issue, parallel testing approach was presented [ 27 , 28 , 29 , 30 , 31 ]. Parallel testing was introduced by Xu et al [ 27 ] in which parallel test droplets were routed on the electrode arrays.…”

Section: Testing Techniques For Conventional Digital Microfluidic mentioning

confidence: 99%

“…The testing time significantly reduced to approximately 75% of that required by the Euler test method due to the reduced complexity of fault diagnosis from O(N2) to O(N). Similarly, an integrated testing and diagnosis method was proposed by Davids et al [ 28 ] to locate single and multiple defects with high fault coverage without flooding. In this methodology, structural testing was used for the outer loop of microfluidic array and parallel testing was used for the inner arrays using multiple droplets.…”

Section: Testing Techniques For Conventional Digital Microfluidic mentioning

confidence: 99%

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Advances in Testing Techniques for Digital Microfluidic Biochips

Shukla

Hussin

Hamid

et al. 2017

Sensors

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With the advancement of digital microfluidics technology, applications such as on-chip DNA analysis, point of care diagnosis and automated drug discovery are common nowadays. The use of Digital Microfluidics Biochips (DMFBs) in disease assessment and recognition of target molecules had become popular during the past few years. The reliability of these DMFBs is crucial when they are used in various medical applications. Errors found in these biochips are mainly due to the defects developed during droplet manipulation, chip degradation and inaccuracies in the bio-assay experiments. The recently proposed Micro-electrode-dot Array (MEDA)-based DMFBs involve both fluidic and electronic domains in the micro-electrode cell. Thus, the testing techniques for these biochips should be revised in order to ensure proper functionality. This paper describes recent advances in the testing technologies for digital microfluidics biochips, which would serve as a useful platform for developing revised/new testing techniques for MEDA-based biochips. Therefore, the relevancy of these techniques with respect to testing of MEDA-based biochips is analyzed in order to exploit the full potential of these biochips.

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Section: Testing Techniques For Conventional Digital Microfluidic mentioning

confidence: 99%

Section: Testing Techniques For Conventional Digital Microfluidic mentioning

confidence: 99%

Advances in Testing Techniques for Digital Microfluidic Biochips

Shukla

Hussin

Hamid

et al. 2017

Sensors

View full text Add to dashboard Cite

show abstract

“…These fluidic devices are connected using electrode paths for droplet routing, and other regions are left unused without any electrode. Previous testing methods target the detection of manufacturing defects in a 2-D regular microfluidic array [6,7,17,21,23,24,27]. In [6], efficient parallel testing and diagnosis algorithms are proposed to detect and locate single as well as multiple faults in a regular microfluidic array.…”

Section: Digital Microfluidic Platform and Related Prior Workmentioning

confidence: 99%

“…Several testing methods have been proposed to detect defects in microfluidic biochips and twodimensional (2-D) regular microfluidic arrays [6,7,11,17,18,21,23,24,27]. In [21], faults were classified as being either catastrophic or parametric, and detected by electrically controlling and tracking the motion of test droplets.…”

Section: Introductionmentioning

confidence: 99%

Testing of Low-cost Digital Microfluidic Biochips with Non-Regular Array Layouts

2011

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Digital microfluidic biochips with non-regular arrays are of interest for clinical diagnostic applications in a cost-sensitive market segment. Previous techniques for biochip testing are limited to regular microfluidic arrays. We present an automatic test pattern generation (ATPG) method for non-regular digital microfluidic chips. The ATPG method can generate test patterns to detect catastrophic defects in non-regular arrays where the full reconfigurability of the digital microfluidic platform is not utilized. It automates test-stimulus design and test-resource selection, in order to minimize the test application time. We also present an integer linear programming model for the compaction of test patterns, while maintaining the desired fault coverage. We utilize two fabricated biochips with non-regular microfluidic arrays to evaluate the proposed ATPG method.

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“…To find a fault within a newly manufactured biochip, it is essential to route a set of test droplets to every edges and cells of entire biochip by controlling the voltage of the electrodes [7,9,[21][22][23]. If the device under test contains any defect, it is prerequisite to identify the defective electrodes.…”

Section: Introductionmentioning

confidence: 99%

An optimized knight traversal technique to detect multiple faults and Module Sequence Graph based reconfiguration of microfluidic biochip

Saha

Majumder

2020

IET Computers & Digital Tech

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Conventional biomedical analysers are replaced by digital microfluidic biochips and they are adequate to integrate different biomedical functions, essential for diverse bioassay operations. From the last decade, microfluidic biochips are getting plenty of acceptances in the field of miscellaneous healthcare sectors like DNA analysis, drug discovery and clinical diagnosis. These devices are also bearing a vital role in the area of safety critical applications such as food safety testing, air quality monitoring etc. As these devices are used in safety critical applications, clinical diagnosis and real-time biomolecular assay operations, these must have properties like precision, reliability and robustness. To accept it for discriminating purposes, the microfluidic device must endorse its preciseness and strength by following sublime testing strategy. Here, an optimized droplet traversal technique is proposed to investigate the multiple defective electrodes of a digital microfluidic biochip by embedding boundary cum row traversal and KNIGHT traversal procedure (based on the famous Knight Tour Problem). The proposed approach also enumerates the traversal time for a fault-free biochip. In addition to identifying the faulty electrodes, a Module Sequencing Graph based reconfiguration technique is proposed here to reinstate the device for normal bioassay operation.This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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A fault detection and diagnosis technique for digital microfluidic biochips

Cited by 11 publications

References 19 publications

Advances in Testing Techniques for Digital Microfluidic Biochips

Advances in Testing Techniques for Digital Microfluidic Biochips

Testing of Low-cost Digital Microfluidic Biochips with Non-Regular Array Layouts

An optimized knight traversal technique to detect multiple faults and Module Sequence Graph based reconfiguration of microfluidic biochip

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