A Fe<sup>3+</sup>-crosslinked pyrogallol-tethered gelatin adhesive hydrogel with antibacterial activity for wound healing

Han, Ning; Xu, Ziyang; Cui, Chunyan; Li, Yuan; Zhang, Dongfei; Xiao, Meng; Fan, Chuanchuan; Wu, Tengling; Yang, Jianhai; Liu, Wenguang

doi:10.1039/d0bm00188k

Cited by 68 publications

(43 citation statements)

References 38 publications

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“…In particular, in the case of the three SG/CMC IPN gels, cell viability was similar to that of CMC gels, which is known to be non-toxic. It has been reported that hydrogels that form IPN through Fe 3+ coordination do not have cytotoxcity [ 55 , 56 , 57 , 58 , 59 ]. On the other hand, the positive control treated with DMSO showed a cell viability of 25%.…”

Section: Resultsmentioning

confidence: 99%

pH-Responsive Succinoglycan-Carboxymethyl Cellulose Hydrogels with Highly Improved Mechanical Strength for Controlled Drug Delivery Systems

Shin

Kim

et al. 2021

Polymers

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Carboxymethyl cellulose (CMC)-based hydrogels are generally superabsorbent and biocompatible, but their low mechanical strength limits their application. To overcome these drawbacks, we used bacterial succinoglycan (SG), a biocompatible natural polysaccharide, as a double crosslinking strategy to produce novel interpenetrating polymer network (IPN) hydrogels in a non-bead form. These new SG/CMC-based IPN hydrogels significantly increased the mechanical strength while maintaining the characteristic superabsorbent property of CMC-based hydrogels. The SG/CMC gels exhibited an 8.5-fold improvement in compressive stress and up to a 6.5-fold higher storage modulus (G′) at the same strain compared to the CMC alone gels. Furthermore, SG/CMC gels not only showed pH-controlled drug release for 5-fluorouracil but also did not show any cytotoxicity to HEK-293 cells. This suggests that SG/CMC hydrogels could be used as future biomedical biomaterials for drug delivery.

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Section: Resultsmentioning

confidence: 99%

pH-Responsive Succinoglycan-Carboxymethyl Cellulose Hydrogels with Highly Improved Mechanical Strength for Controlled Drug Delivery Systems

Shin

Kim

et al. 2021

Polymers

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“…Gelatin also has excellent hydrophilicity, which can absorb wound exudate and maintain a moist environment in the wound area. [ 43 ] At the same time, gelatin, as a partial hydrolysate of collagen, can also participate in the deposition of collagen in the wound area, so it is widely used to prepare hydrogel wound adhesives and clinically used to treat skin, [ 44 ] blood vessels, [ 45 ] gastrointestinal tract, [ 46 ] and lung wounds. [ 47 ] Due to the rich of amino groups, gelatin mainly reacts with aldehyde crosslinking agents (such as glutaraldehyde, and amino polysaccharides, etc.)…”

Section: Typical Types Of Hydrogel Adhesivesmentioning

confidence: 99%

Hydrogel adhesives for generalized wound treatment: Design and applications

Pan

Zhang

et al. 2022

Journal of Polymer Science

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Wound refers to the place where human body is injured and ruptured. So, wounds in a broad sense include not only skin wounds, but also damages of muscle, corneal, heart, and lung, etc. As "gold standard" of wound closure, suture and staple cause secondary damage to the tissue, and require professional skills and equipment, so noninvasive hydrogel adhesives have been developed as an alternative to close and treat different kinds of wounds. However, the existing reviews mainly discussed the research of hydrogel adhesives for skin wounds, and the focus is mostly on its types and adhesion mechanisms, but a review comprehensively discusses the design and application of hydrogel adhesives on generalized wounds for wound closure and wound healing and the unique needs of various wounds for hydrogel adhesives is still lacking. In this review, the types and adhesion mechanisms of hydrogel adhesives will be briefly described, then the research progress of hydrogel adhesives in wound treatment is reviewed in detail from two aspects: the comprehensive design principles and the unique requirements of different types of wounds. Overall, we expect that this review will provide guidance for the development of hydrogel adhesives as new avenues for generalized wound care and treatment.

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“…Indeed, the wet-contact adhesive strengths of the PVA/PTPM NH coatings on both silicate glass and PMMA were much higher than many commercial glues and high-performance polymeric adhesives in literatures (Figure 2h). [39,44,[49][50][51][52][53][54][55][56][57] Even for two surfaces of dissimilar materials, this PVA/PTPM NH could still glue them. For examples, the wet-contact adhesive strengths between glass slides to steel, aluminum and PMMA slides were found to be ≈1091 ± 159, ≈1082 ± 128, and ≈839 ± 83 KPa, respectively (Figure S18, Supporting Information).…”

Section: Structural and Mechanical Characteristics Of Pva/ptpm Hn Ant...mentioning

confidence: 99%

Effective Antifogging Coating from Hydrophilic/Hydrophobic Polymer Heteronetwork

Shi

Qiu

2022

Advanced Science

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Fogging on optical devices may severely impair vision, resulting in unacceptable adverse consequences. Hydrophilic coatings can prevent surface fogging by instantly facilitating pseudo-film water condensation but suffer from short antifogging duration due to water film thickening with further condensation. Here, an innovative strategy is reported to achieve longer antifogging duration via thickening the robust bonded hydrophilic/hydrophobic polymer heteronetwork coating to enhance its water absorption capacity. The combination of strong interfacial adhesion and hydrophilic/hydrophobic heteronetwork structure is key to this approach, which avoids interfacial failure and swelling-induced wrinkles under typical fogging conditions. The developed antifogging coating exhibits prolonged antifogging durations over a wide temperature range for repetitious usages. Eyeglasses coated with this coating successfully maintained fog-free vision in two typical scenarios. Besides, the coating recipes developed in this study also have potential as underwater glues as they demonstrate strong adhesions to both glass and polymer substrates in wet conditions.

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A Fe³⁺-crosslinked pyrogallol-tethered gelatin adhesive hydrogel with antibacterial activity for wound healing

Abstract: A tunicate-inspired gelatin-based hydrogel prepared by a simple mixing method, exhibits strong adhesion and antibacterial capacity, and facilitates wound healing.

Cited by 68 publications

References 38 publications

pH-Responsive Succinoglycan-Carboxymethyl Cellulose Hydrogels with Highly Improved Mechanical Strength for Controlled Drug Delivery Systems

pH-Responsive Succinoglycan-Carboxymethyl Cellulose Hydrogels with Highly Improved Mechanical Strength for Controlled Drug Delivery Systems

Hydrogel adhesives for generalized wound treatment: Design and applications

Effective Antifogging Coating from Hydrophilic/Hydrophobic Polymer Heteronetwork

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A Fe3+-crosslinked pyrogallol-tethered gelatin adhesive hydrogel with antibacterial activity for wound healing

Abstract: A tunicate-inspired gelatin-based hydrogel prepared by a simple mixing method, exhibits strong adhesion and antibacterial capacity, and facilitates wound healing.

Cited by 68 publications

References 38 publications

pH-Responsive Succinoglycan-Carboxymethyl Cellulose Hydrogels with Highly Improved Mechanical Strength for Controlled Drug Delivery Systems

pH-Responsive Succinoglycan-Carboxymethyl Cellulose Hydrogels with Highly Improved Mechanical Strength for Controlled Drug Delivery Systems

Hydrogel adhesives for generalized wound treatment: Design and applications

Effective Antifogging Coating from Hydrophilic/Hydrophobic Polymer Heteronetwork

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Product

Resources

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A Fe³⁺-crosslinked pyrogallol-tethered gelatin adhesive hydrogel with antibacterial activity for wound healing