A Feasibility Study on Model-based Evaluation of Kidney Perfusion Measured by Means of FAIR Prepared True-FISP Arterial Spin Labeling (ASL) on a 3-T MR Scanner

Kiefer, Claus; Schroth, Gerhard; Gralla, Jan; Diehm, N; Baumgartner, Iris; Husmann, Mare

doi:10.1016/j.acra.2008.04.024

Cited by 27 publications

(18 citation statements)

References 30 publications

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“…The findings can be attributed to the perfusion difference of the renal cortex and medulla 10, 30 . The degree of perfusion impairment measured using arterial spin labeling has been reported to be related to kidney volume loss, the severity of renal tissue alterations, and the impairment of renal function 10, 30, 31 .…”

Section: Discussionmentioning

confidence: 94%

Severe bilateral ischemic-reperfusion renal injury: hyperacute and acute changes in apparent diffusion coefficient, T1, and T2 mapping with immunohistochemical correlations

Yip

Zhen

et al. 2017

Sci Rep

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The aim of this study was to investigate the hyperacute and acute changes in apparent diffusion coefficient (ADC), T1, and T2 mapping in rat kidneys after severe bilateral renal ischemic-reperfusion injury (IRI). After baseline MRI, 24 Spraque-Dawley rats with renal IRI were divided equally as group 1 (post-IRI MRI at 6 hours, days 1, 3, and 7) and groups 2, 3, and 4 (post-IRI MRI at 6 hours; 6 hours and day 1; 6 hours, days 1 and 3, respectively), while six other rats without IRI (group 5) were used as sham control. ADC, T1, and T2 values of the cortex and outer and inner stripes of outer medulla (OSOM and ISOM), and immunohistochemical studies assessing monocyte chemoattractant protein-1 (MCP-1), CD68+ cells, tubular cast formation, and collagen deposition in three zones at different time points were evaluated. Significantly reduced ADCs in OSOM and ISOM are noninvasive biomarkers denoting hyperacute damages after IRI. Linear regression analysis revealed a significant inverse correlation between 6-hour/baseline ADC ratios and MCP-1 staining (P < 0.001, r2 = 0.738). ADC, T1, and T2 values are useful for assessing variable IRI changes in different layers depending on underlying microstructural and histopathological changes at different time points.

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Section: Discussionmentioning

confidence: 94%

Severe bilateral ischemic-reperfusion renal injury: hyperacute and acute changes in apparent diffusion coefficient, T1, and T2 mapping with immunohistochemical correlations

Yip

Zhen

et al. 2017

Sci Rep

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“…Renal cortical perfusion values obtained in normal subjects using ASL found in the literature vary varied from 213 ± 55 mL min -1 100 g -1 with a range from 140 to 319 mL min -1 100 g -1 [11], 245 ± 11 mL min -1 100 g -1 using a 3T system [34], 375 ± 54 mL min -1 100 g -1 [23] to 407-456 mL min -1 100 g -1 with mean 427 ± 20 mL min -1 100 g -1 [15]. All these publications used the simplified kinetic model based on a single TI acquisition to calculate renal perfusion.…”

Section: Discussionmentioning

confidence: 97%

Repeatability of renal arterial spin labelling MRI in healthy subjects

Cutajar¹,

Thomas²,

Banks

et al. 2012

Magn Reson Mater Phy

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“…Recent studies have found qualitative agreement between MRI-ASL and scintigraphy with respect to kidney perfusion measurement (14,25). MRI-ASL methodology is advantageous compared with other methods to measure kidney perfusion due to the speed of analysis (within a few minutes) and its noninvasive nature (11,20). The fact that ASL evaluations do not involve exogenous contrast medium bestows several benefits and opportunities for renal regional blood flow assessment.…”

Section: Discussionmentioning

confidence: 99%

Arterial spin labeling blood flow magnetic resonance imaging for evaluation of renal injury

Liu

Song

Liang

et al. 2012

American Journal of Physiology-Renal Physiology

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Liu YP, Song R, Liang Ch, Chen X, Liu B. Arterial spin labeling blood flow magnetic resonance imaging for evaluation of renal injury. Am J Physiol Renal Physiol 303: F551-F558, 2012. First published May 30, 2012 doi:10.1152/ajprenal.00288.2011.-A multitude of evidence suggests that iodinated contrast material causes nephrotoxicity; however, there have been no previous studies that use arterial spin labeling (ASL) blood flow functional magnetic resonance imaging (fMRI) to investigate the alterations in effective renal plasma flow between normointensive and hypertensive rats following injection of contrast media. We hypothesized that FAIR-SSFSE arterial spin labeling MRI may enable noninvasive and quantitative assessment of regional renal blood flow abnormalities and correlate with disease severity as assessed by histological methods. Renal blood flow (RBF) values of the cortex and medulla of rat kidneys were obtained from ASL images postprocessed at ADW4.3 workstation 0.3, 24, 48, and 72 h before and after injection of iodinated contrast media (6 ml/kg). The H&E method for morphometric measurements was used to confirm the MRI findings. The RBF values of the outer medulla were lower than those of the cortex and the inner medulla as reported previously. Iodinated contrast media treatment resulted in decreases in RBF in the outer medulla and cortex in spontaneously hypertensive rats (SHR), but only in the outer medulla in normotensive rats. The iodinated contrast agent significantly decreased the RBF value in the outer medulla and the cortex in SHR compared with normotensive rats after injection of the iodinated contrast media. Histological observations of kidney morphology were also consistent with ASL perfusion changes. These results demonstrate that the RBF value can reflect changes of renal perfusion in the cortex and medulla. ASL-MRI is a feasible and accurate method for evaluating nephrotoxic drugs-induced kidney damage.

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A Feasibility Study on Model-based Evaluation of Kidney Perfusion Measured by Means of FAIR Prepared True-FISP Arterial Spin Labeling (ASL) on a 3-T MR Scanner

Cited by 27 publications

References 30 publications

Severe bilateral ischemic-reperfusion renal injury: hyperacute and acute changes in apparent diffusion coefficient, T1, and T2 mapping with immunohistochemical correlations

Severe bilateral ischemic-reperfusion renal injury: hyperacute and acute changes in apparent diffusion coefficient, T1, and T2 mapping with immunohistochemical correlations

Repeatability of renal arterial spin labelling MRI in healthy subjects

Arterial spin labeling blood flow magnetic resonance imaging for evaluation of renal injury

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