A feasibility study on non-invasive oxidative metabolism detection and acoustic assessment of human vocal cords by using optical technique

Abstract

Voice disorder such as vocal fatigue is a common and complex multifaceted clinical problem that presents a significant impact on quality of life. In this study, the functional near-infrared diffuse optical technique (fNIRS-DOT) was proposed as a novel approach for human vocal cords oxidative metabolism detection and acoustic assessment simultaneously to provide a multidimensional assessment of voice disorder. A totally of 60 healthy subjects included 30 male and 30 female adults of age-matched were recruited and performed a vocal loading task to trigger a mild inflammation of the vocal cords in this study. In the results of oxidative metabolism, the vocal cords expressed hypoxia after vocal loading task in both male and female groups that could provide relevant information on the relationship between tissue oxygen consumption and supply for vocal cords diagnosis. Additionally, the results of optical acoustic assessment revealed the worse/changes voice quality after vocal loading task. Therefore, integration of non-invasive oxidative metabolism detection and acoustic assessment by using optical technique could provide more relevant information for diagnosis of voice disorders. The multi-functional vocal cords detection system could provide a good feasibility for clinical applications such as diagnosis and therapeutic monitoring of voice disorder.

Tipos de fibras de los músculos intrínsecos laríngeos de seres humanos: una revisión de la literatura

“…Clínicamente, los resultados obtenidos permiten dirigir con mayor precisión la carga durante la ejercitación o en el entrenamiento de los músculos fonatorios. Esto se puede llevar a cabo gracias al entendimiento de las distintas vías energéticas que predominan durante la producción de la voz, donde (según los últimos hallazgos), habría mayor preponderancia aeróbica, oxidativa o mitocondrial (Lin et al, 2017;Nanjundeswaran et al, 2017;Tellis et al, 2011). En este caso, las fibras tipo I, IIA y las cadenas lentas son las que se activarían preferentemente para realizar la actividad muscular propia de la fonación (Johnson & Sandage, 2019).…”

The Protective Effect of Echinochrome A on Extracellular Matrix of Vocal Folds in Ovariectomized Rats

“…Oxidative stress is related to voice changes caused by vocal scar and aging [27][28][29]. Antioxidants have been used to prevent vocal fold scars by improving vocal fold wound healing [11,12].…”