1980
DOI: 10.1016/0026-2862(80)90024-2
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A fiber matrix model of capillary permeability

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Cited by 369 publications
(219 citation statements)
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“…Consisting of a highly hydrated mesh of membraneassociated proteoglycans, glycosaminoglycans, glycoproteins and glycolipids [12,13], the glycocalyx is present on the endothelial surface layer and within the intercellular cleft; it is not merely an inert intercellular cement as once thought [14], but understood to be a very dynamic structure. The possible existence of an ordered structure was first proposed by Curry and Michel [15] to explain why there is a sharp break in the solute permeability versus Stokes-Einstein relationship for molecules the size of albumin [16]. The ability to selectively allow passage of water and solutes across the vessel wall is described in terms of the spacing between the fibres of the glycocalyx (i.e.…”
Section: Reflection Coefficient (σ)mentioning
confidence: 99%
“…Consisting of a highly hydrated mesh of membraneassociated proteoglycans, glycosaminoglycans, glycoproteins and glycolipids [12,13], the glycocalyx is present on the endothelial surface layer and within the intercellular cleft; it is not merely an inert intercellular cement as once thought [14], but understood to be a very dynamic structure. The possible existence of an ordered structure was first proposed by Curry and Michel [15] to explain why there is a sharp break in the solute permeability versus Stokes-Einstein relationship for molecules the size of albumin [16]. The ability to selectively allow passage of water and solutes across the vessel wall is described in terms of the spacing between the fibres of the glycocalyx (i.e.…”
Section: Reflection Coefficient (σ)mentioning
confidence: 99%
“…There is accumulating evidence that the endothelial glycocalyx is also a significant determinant of vascular permeability (Curry & Michel, 1980 ;Simionescu & Simionescu, 1984 ;Vorbrodt, 1988Vorbrodt, ,1994. The glycocalyx mainly comprises oligosaccharide moieties of plasmalemmal glycoproteins, and the notion that these fibrous macromolecules can influence permeability is encompassed in the ' fibre-matrix model ' (Curry & Michel, 1980 ;Michel, 1988Michel, , 1996.…”
Section: mentioning
confidence: 99%
“…The glycocalyx mainly comprises oligosaccharide moieties of plasmalemmal glycoproteins, and the notion that these fibrous macromolecules can influence permeability is encompassed in the ' fibre-matrix model ' (Curry & Michel, 1980 ;Michel, 1988Michel, , 1996. In the fibre-matrix model the endothelial glycocalyx is proposed to act as a molecular sieve which can differentiate between molecules on the basis of their size.…”
Section: mentioning
confidence: 99%
“…Microvessel permeability also has been associated with the luminal glycocalyx (Baldwin and Thurston, 2001;Curry and Michel, 1980;Michel and Curry, 1999). van den Berg et al (2003) used hyaluronidase to target hyaluronan, a component of the glycocalyx, and demonstrated that enzyme digestion not only decreased thickness of the glycocalyx, but also increased the pericapillary space, indicative of myocardial tissue edema.…”
Section: Introductionmentioning
confidence: 99%