Chapter 1. Introduction Chapter 2. Electron beam induced shape-deformation of silica based particles in liquid phase electron microscopy Chapter 3. Liquid cell scanning transmission electron microscopy study of diffusion of colloidal particles inside spherical shells Chapter 4. In-situ study of the wet chemical etching of SiO 2 and Metal(oxide)@SiO 2 core-shell nanospheres Chapter 5. Complex internal chemical structures of rod-shaped silica colloids investigated by in-situ etching using low-dose liquid cell electron microscopy