Space-fractional diffusion problems are investigated from the modeling point of view. It is pointed out that the elementwise power of the Laplacian operator in R n is an inadequate model of fractional diffusion. Also, the approach with fractional calculus using zero extension is not a proper model of homogeneous Dirichlet boundary conditions. At the time, the spectral definition of the fractional Dirichlet Laplacian seems to be in many aspects a proper model of fractional diffusion.