A first method for preparation of biodegradable fibrous scaffolds containing iodine on the fibre surfaces

Goreninskii, S. I.; Stankevich, Ksenia S.; Nemoykina, Anna L.; Bolbasov, E. N.; Tverdokhlebov, Sergei I.; Филимонов, В. Д.

doi:10.1007/s12034-018-1625-z

Cited by 5 publications

(2 citation statements)

References 18 publications

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“…A promising approach for modifying the surface of biodegradable polyesters involves treatment of the polymer with a mixture of organic solvents to partially swell its surface [ 41 , 42 , 43 ]. It was shown that a mixture of toluene and ethanol has no destructive effect on the PCL scaffold structure and allows non-covalent immobilization of gelatin and iodine.…”

Section: Resultsmentioning

confidence: 99%

Long Bone Defect Filling with Bioactive Degradable 3D-Implant: Experimental Study

et al. 2023

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Previously, 3D-printed bone grafts made of titanium alloy with bioactive coating has shown great potential for the restoration of bone defects. Implanted into a medullary canal titanium graft with cellular structure demonstrated stimulation of the reparative osteogenesis and successful osseointegration of the graft into a single bone-implant block. The purpose of this study was to investigate osseointegration of a 3D-printed degradable polymeric implant with cellular structure as preclinical testing of a new technique for bone defect restoration. During an experimental study in sheep, a 20 mm-long segmental tibial defect was filled with an original cylindrical implant with cellular structure made of polycaprolactone coated with hydroxyapatite. X-ray radiographs demonstrated reparative bone regeneration from the periosteum lying on the periphery of cylindrical implant to its center in a week after the surgery. Cellular structure of the implant was fully filled with newly-formed bone tissue on the 4th week after the surgery. The bone tissue regeneration from the proximal and distal bone fragments was evident on 3rd week. This provides insight into the use of bioactive degradable implants for the restoration of segmental bone defects. Degradable implant with bioactive coating implanted into a long bone segmental defect provides stimulation of reparative osteogenesis and osseointegration into the single implant-bone block.

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Section: Resultsmentioning

confidence: 99%

Long Bone Defect Filling with Bioactive Degradable 3D-Implant: Experimental Study

et al. 2023

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“…A promising approach for modifying the surface of PCL involves treatment of the polymer with a mixture of organic solvents to partially swell its surface [21]. The swelled surface layer of the polymer can adsorb biologically active molecules and particles from the contacting medium.…”

Section: Introductionmentioning

confidence: 99%

Solvent/non-solvent treatment as a method for surface coating of poly(ε-caprolactone) 3D-printed scaffolds with hydroxyapatite

Bocharov,

Dubinenko,

Popkov

et al. 2023

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Introduction Over the last decades numerous new materials and techniques for bone tissue engineering have been developed. The use of bioresorbable polymeric scaffolds is one of the most promising techniques for surgical management of bone defects. However, the lack of bioactive properties of biodegradable polymers restricts the area of their application for bone tissue engineering.The aim of study was to apply solvent/non-solvent treatment to coat the surface of 3D-printed bioresorbable poly(ε-caprolactone) scaffolds with bioactive hydroxyapatite particles and report on the physicochemical properties of the resulting materials.Material and Methods In the present study, biomimetic poly(ε-caprolactone) scaffolds were 3D-printed via fused deposition modeling technology and their surface was treated with the solvent/non-solvent method for coating with bioactive particles of hydroxyapatite.Results It has been found that treatment in the mixture of toluene and ethanol is suitable for the coating of poly(ε-caprolactone) scaffolds with hydroxyapatite. The scaffolds maintain porous structure after treatment while hydroxyapatite particles form homogeneous coating. The amount of hydroxyapatite on the treated scaffolds was 5.7 ± 0.8 wt. %.Discussion The proposed method ensures a homogeneous coating of outer and inner surfaces of the poly(ε-caprolactone) scaffolds with hydroxyapatite without a significant impact on the structure of a scaffold. Fourier-transform infrared spectroscopy confirmed that the solvent/non-solvent treatment has no effect on the chemical structure of PCL scaffolds.Conclusion Coating of biomimetic 3D-printed PCL scaffolds with bioactive hydroxyapatite by the solvent/non-solvent treatment has been successfully carried out. Upon coating, scaffolds retained their shape and interconnected porous structure and adsorbed hydroxyapatite particles that were uniformly distributed on the surface of the scaffold.

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Solvent-cast direct-writing as a fabrication strategy for radiopaque stents

Chausse

Schieber

Raymond

et al. 2021

Additive Manufacturing

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A first method for preparation of biodegradable fibrous scaffolds containing iodine on the fibre surfaces

Cited by 5 publications

References 18 publications

Long Bone Defect Filling with Bioactive Degradable 3D-Implant: Experimental Study

Long Bone Defect Filling with Bioactive Degradable 3D-Implant: Experimental Study

Solvent/non-solvent treatment as a method for surface coating of poly(ε-caprolactone) 3D-printed scaffolds with hydroxyapatite

Solvent-cast direct-writing as a fabrication strategy for radiopaque stents

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