A first reported case of clear cell carcinoma associated with delayed extrusion of midurethral tape

Lin, Harvard Zhenjia; Wu, Fiona Mei Wen; Low, Jonathan Sze Choong; Venkateswaran, Kotamma; Ng, Ren

doi:10.1007/s00192-015-2876-5

Cited by 9 publications

(3 citation statements)

References 18 publications

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“…11 Concerns regarding mesh and carcinogenesis stem from historical animal studies, explanted mesh analyses and rare case reports. 24–28 Studies have repeatedly shown that an implant’s physical composition and size rather than its chemical composition determines carcinogenicity. 12 There is a loss of carcinogenicity when implants of various compositions are imbedded in a powder, porous or woven form in animals.…”

Section: Discussionmentioning

confidence: 99%

Stress Incontinence Surgery Does Not Cause Pelvic Malignancy: A Population-Based Cohort Study

Vigil

Wallis

Zhang³

et al. 2021

Journal of Urology

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Purpose: We sought to determine if stress urinary incontinence surgery (mesh or nonmesh) is associated with the development of pelvic malignancies later in life. Materials and Methods: We performed a retrospective cohort study between January 1, 2002 and October 31, 2015 of all women in Ontario, Canada without a history of pelvic malignancy who underwent an index stress incontinence surgery. The primary outcome was a composite of any pelvic malignancy (including urological and gynecological cancers) following stress incontinence surgery. Secondarily, we considered each cancer individually. A survival analysis using a Cox proportional-hazards model with a 3-level categorical exposure (mesh surgery, nonmesh surgery, and control) was performed. Patients were followed until death, emigration or the study end (October 31, 2017). Results: Of the women 74,968 underwent stress urinary incontinence surgery during the study period. There were 5,505,576 women in the control group. Over a median followup of 8.5 years (IQR, 5.5e11.9), 587 pelvic malignancies occurred in the surgery group. Women who underwent stress incontinence surgery had a reduced risk of pelvic malignancy independent of surgery type, compared to controls (Wald type 3 p <0.001; mesh HR, 0.68 [95% CI, 0.62e0.76]; p <0.0001; nonmesh HR, 0.37 [95% CI, 0.29e0.46]; p <0.0001). The individual pelvic cancers similarly demonstrated a reduced risk of malignancy following stress incontinence surgery. Conclusions: At a median followup of 8.5 years, women had no increased risk of pelvic malignancy following either mesh or nonmesh stress urinary incontinence surgery in a large population-based cohort.

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Section: Discussionmentioning

confidence: 99%

Stress Incontinence Surgery Does Not Cause Pelvic Malignancy: A Population-Based Cohort Study

Vigil

Wallis

Zhang³

et al. 2021

Journal of Urology

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“…Similar materials are also used in urogenital surgical procedures, especially in sling techniques for stress urinary incontinence (210). Recently a case of clear cell carcinoma associated with delayed extrusion of mid-urethral polypropylene tape was reported 10 years after insertion (211). The authors' explanation for malignant degeneration was a possible mutation due to longstanding chronic tissue inflammation caused by mesh as a foreign body.…”

Section: Discussionmentioning

confidence: 99%

Hernia and Cancer: The Points Where the Roads Intersect

Kulaçoğlu¹,

Köckerling

2019

Front. Surg.

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Introduction: This review aimed to present common points, intersections, and potential interactions or mutual effects for hernia and cancer. Besides direct relationships, indirect connections, and possible involvements were searched. Materials and Methods: A literature search of PubMed database was performed in July 2018 as well as a search of relevant journals and reference lists. The total number of screened articles was 1,422. Some articles were found in multiple different searches. A last PubMed search was performed during manuscript writing in December 2018 to update the knowledge. Eventually 427 articles with full text were evaluated, and 264 included, in this review. Results: There is no real evidence for a possible common etiology for abdominal wall hernias and any cancer type. The two different diseases had been found to have some common points in the studies on genes, integrins, and biomarkers, however, to date no meaningful relationship has been identified between these points. There is also some, albeit rather conflicting, evidence for inguinal hernia being a possible risk factor for testicular cancer. Neoadjuvant or adjuvant therapeutic modalities like chemotherapy and radiotherapy may cause postoperative herniation with their adverse effects on tissue repair. Certain specific substances like bevacizumab may cause more serious complications and interfere with hernia repair. There are only two articles in PubMed directly related to the topic of “hernia and cancer.” In one of these the authors claimed that there was no association between cancer development and hernia repair with mesh. The other article reported two cases of squamous-cell carcinoma developed secondary to longstanding mesh infections. Conclusion: As expected, the relationship between abdominal wall hernias and cancer is weak. Hernia repair with mesh does not cause cancer, there is only one case report on cancer development following a longstanding prosthetic material infections. However, there are some intersection points between these two disease groups which are worthy of research in the future.

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“…In the vagina it is often associated with in utero diethylstilbestrol (DES) exposure, while in the urethra the majority of such cancers are associated with a urethral diverticulum. The report by Lin et al [1] describes a patient who presented with urinary retention and symptoms of a urinary tract infection (UTI) who was found upon examination to have mesh exposure in the vaginal fornix and an inflamed and tender anterior vaginal wall. She received a transvaginal tape obturator (TVTo) (Gynecare, Johnson & Johnson, Somerville, NJ, USA) 10 years earlier.…”

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confidence: 99%