Earth departure options such as the location for deployment, aggregation, and crew rendezvous as well as the type of propulsion leveraged for each mission phase effect overall mission performance metrics such as number of critical maneuvers, mass of propellant to achieve departure, and initial mass required in low Earth orbit. This paper identifies and compares a subset of tactical options for deployment, crew rendezvous, and Earth departure that leverage electric propulsion and hybrid chemical electric propulsion with a goal of improving system efficiency. Departure maneuver specific limitations and penalties are then identified for missions to specific targets for human interplanetary missions providing a better understanding of the impact of decisions related to aggregation and rendezvous locations as well as Earth departure maneuvers on overall system performance.