A floating 3D printed polypill formulation for the coadministration and sustained release of antihypertensive drugs

Zgouro, Paola; Katsamenis, Orestis L.; Moschakis, Thomas; Eleftheriadis, Georgios K.; Kyriakidis, Athanasios S.; Chachlioutaki, Konstantina; Kyriaki Monou, Paraskevi; Ntorkou, Marianna; Zacharis, Constantinos K.; Bouropoulos, Nikolaos; Fatouros, Dimitrios G.; Karavasili, Christina; Gioumouxouzis, Christos I.

doi:10.1016/j.ijpharm.2024.124058

International Journal of Pharmaceutics

2024

DOI: 10.1016/j.ijpharm.2024.124058

|View full text |Cite

A floating 3D printed polypill formulation for the coadministration and sustained release of antihypertensive drugs

Paola Zgouro,

Orestis L. Katsamenis,

Thomas Moschakis

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article5

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 6 publications

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Mechanochemical‐Induced Swelling–Activation of a Gastric‐Deployable 4D‐Printed Polypill Inspired by Natural Hygromorphic Actuators

Chachlioutaki,

Papas,

Chatzis

et al. 2024

Advanced Intelligent Systems

View full text Add to dashboard Cite

Gastroretentive drug delivery systems can improve adherence in patients with chronic diseases (CDs), but current options lack dose flexibility and involve complex fabrication methods. Inspired by the hygroscopic deformation observed in multilayered pine cone scales, wherein hydration of the outer active layer induces cone closure, a one‐step fabrication method of a personalized 4D‐printed water‐actuated four‐arm polypill is demonstrated in this study. The bilayer‐arm polypill self‐deploys upon ingestion to prolong gastric retention and sustain drug release. By inversing the orientation of the swellable active layer at the polypill arms compared to pine cone scales, a differential swelling strain develops generating bending force that enables polypill deployment to constrain passage through the pylorus. Finite‐element analysis is used to model spatial changes in polymer phase swelling to ensure adequate deployment within the timeframe of gastric emptying. In a stomach model, the polypill expanded to 30 mm over 2 h, exceeding the diameter of the stomach model's distal end. In an in vitro release screening, biocompatible polymer composites capable of providing up to 6 days of release for a three‐drug combination for tuberculosis–HIV coinfected patients are identified. The bioinspired 4D‐printed polypill can serve as drug delivery platform for a range of CDs.

show abstract

Mechanochemical‐Induced Swelling–Activation of a Gastric‐Deployable 4D‐Printed Polypill Inspired by Natural Hygromorphic Actuators

Chachlioutaki,

Papas,

Chatzis

et al. 2024

Advanced Intelligent Systems

View full text Add to dashboard Cite

show abstract

Evolution, integration, and challenges of 3D printing in pharmaceutical applications: A comprehensive review

Kumari,

Pandey,

Jangde

et al. 2024

Bioprinting

View full text Add to dashboard Cite

Current trends in 3D printed gastroretentive floating drug delivery systems: A comprehensive review

Mora-Castaño,

Domínguez-Robles,

Himawan

et al. 2024

International Journal of Pharmaceutics

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

A floating 3D printed polypill formulation for the coadministration and sustained release of antihypertensive drugs

Cited by 6 publications

References 53 publications

Mechanochemical‐Induced Swelling–Activation of a Gastric‐Deployable 4D‐Printed Polypill Inspired by Natural Hygromorphic Actuators

Mechanochemical‐Induced Swelling–Activation of a Gastric‐Deployable 4D‐Printed Polypill Inspired by Natural Hygromorphic Actuators

Evolution, integration, and challenges of 3D printing in pharmaceutical applications: A comprehensive review

Current trends in 3D printed gastroretentive floating drug delivery systems: A comprehensive review

Contact Info

Product

Resources

About