A flow analysis system integrating an optoelectronic detector for the quantitative determination of active ingredients in pharmaceutical formulations

Jeber, Jalal N.

doi:10.1016/j.microc.2020.105710

Cited by 16 publications

(9 citation statements)

References 38 publications

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“…Therefore, combining these factors with chemiluminescence (CL) is extremely attractive. [27][28][29] In this paper, it is reported that a CL signal is generated when Cr(III) is reacted with diethyl amino phenyl hydrazine (DEAPH) in the presence of hydrogen peroxide. However, under the same experimental conditions, Cr(VI) does not react and does not show any CL behaviour.…”

Section: Introductionmentioning

confidence: 99%

Online column preconcentration for speciation and selective determination of Cr(III) in natural water samples using flow injection with chemiluminescence detection

Jasim

Kamel²,

Al-Awadi

et al. 2023

Luminescence

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A simple, rapid, sensitive and inexpensive approach is described in this work based on a combination of solid‐phase extraction of 8‐hydroxyquinoline (8HQ), for speciation and preconcentration of Cr(III) and Cr(VI) in river water, and the direct determination of these species using a flow injection system with chemiluminescence detection (FI–CL) and a 4‐diethylamino phenyl hydrazine (DEAPH)–hydrogen peroxide system. At different pH, the two forms of chromium [Cr(III) and Cr(VI)] have different exchange capacities for 8HQ, therefore two columns were constructed; the pH of column 1 was adjusted to pH 3 for retaining Cr(III) and column 2 was adjusted to pH 1 for retaining of Cr(VI). The sorbed Cr(III) and Cr(VI) species were eluted from columns using 3.0 ml of 0.1 N of HCl and 3.0 ml of 0.1 N of NaOH, respectively. The flow injection–chemiluminescence (FI–CL) method is based on light emitted due to the oxidation of DEAPH by the H2O2 in the presence of Cr(III), which catalyzes the reaction. The flow cell is a transparent coiled tube made from glass (2.0 × 4.0, inner and outer diameter) and located close to the photodetector. The flow parameters: flow rate, sample volume, flow cell length, and distance to the CL detector were studied and optimized. Under optimum flow conditions, the Cr(III) concentration can be determined over the range 5–350 μg L−1 with a limit of detection of 1.2 μg L−1, as the Cr(III) concentration is proportional to the intensity of the CL signal. The relative standard deviations (%) for 10 and 50 μg L−1 Cr(III) were 1.2% and 3.2%, respectively. The effects of Al(III), Cd(II), Zn(II), Hg(II), Pb(II), Co(II), Cu(II), Ni(II), Mn(II), Ca(II), and Fe(III) were investigated. The proposed method is highly selective and sensitive, enabling a rapid determination of the Cr(III) amount in the presence of other interfering metals. Finally, the FI–CL method was examined in five river water samples with excellent recoveries.

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Section: Introductionmentioning

confidence: 99%

Online column preconcentration for speciation and selective determination of Cr(III) in natural water samples using flow injection with chemiluminescence detection

Jasim

Kamel²,

Al-Awadi

et al. 2023

Luminescence

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“…Therefore, in the present study, three critical aspects -robustness, narrow linearity range and lack of reliability were attempted to be developed by the authors. The turbidity concept is a widely used quantitative determination approach and lots of active ingredients have been determined using this technique such as cyproheptadine hydrochloride, 27,28 ephedrine Hydrochloride, 29 ciprofloxacin HCl, 30 paracetamol, 31 and sulfanilamide. 32 The main objective of the current study was to develop and validate an analysis method depending on turbidity concept combined with a flow injection technique, which allows simultaneous quantitative determination of MBH in pharmaceutical formulations for the same injected sample using two consecutive detection zones.…”

Section: Introductionmentioning

confidence: 99%

Investigation and Comparison of Antioxidant Potential of Catechins Present in Green Tea: DFT Study

Wijesooriya¹,

Pandithavidana²

2022

ChChT

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DFT calculations were applied to compare the antioxidant potential of four major catechins present in green tea. The thermodynamic parameters related to three key mechanisms of primary antioxidant action were investigated in detail. Molecular orbital energies, absolute hardness, electronegativity, and electrophilicity index, which contributed to the radical scavenging were also investigated. The radical scavenging potential of each hydroxyl group of these polyphenolic antioxidants were investigated independently.

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“…[23] Flow injection-spectrophotometric technique is the most commonly used for determination of active pharmaceutical ingredients in their formulations, using this technique for pesticide determination is the most required in the field of pesticide determination. [24][25][26][27][28][29][30][31][32][33][34][35][36] To the best of our knowledge, the flow injection technique with indirect photometric detection for the determination of fosetyl-Al in commercial samples of protection products has not been applied. The main aim of the present study is to develop and validate a rapid, simple and reliable analytical method for the assay of fosetyl-Al in pesticide formulations that uses the most common available instrument in the laboratories which is (Photometry).…”

Section: Introductionmentioning

confidence: 99%

“…Flow injection‐spectrophotometric technique is the most commonly used for determination of active pharmaceutical ingredients in their formulations, using this technique for pesticide determination is the most required in the field of pesticide determination [24–36] . To the best of our knowledge, the flow injection technique with indirect photometric detection for the determination of fosetyl‐Al in commercial samples of protection products has not been applied.…”

Section: Introductionmentioning

confidence: 99%

A Continuous Flow Injection/Indirect Photometric Method for the Detection of Fosetyl Aluminum in Commercial Pesticide Formulations

Sadiq

Hammood

2022

ChemistrySelect

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Because of their Physico-chemical characteristics and its composition, the development of new specific analytical methodologies to determine some highly polar pesticides are required. The reported methods demand long analysis time, expensive instruments and prior extraction of pesticide for detection. The current work presents a new flow injection analysis method combined with indirect photometric detection for the determination of Fosetyl-Aluminum (Fosetyl-Al) in commercial formulations, with rapid and highly accurate determination involving only construction of manifold system combined with photometric detector without need some of the pre-treatments to the sample before the analysis such as extraction or separation. The proposed method is based on the reaction between the Fosetyl-Al with the colorimetric reagent (Aluminon dye) in an aqueous medium of sodium nitrite resulting in the formation of a red complex and its absorbance is measured using the photometric detector. The proposed method included optimization of several parameters such as sodium nitrite concentration, flow rate, sample volume, Aluminon dye concentration, mixing coil and light intensity. The linear range of the detector response was in the range of 0.005-1.8 mmol/L for the sample with r (coefficient of determination) 0.9909, R 2 (correlation coefficient) 0.9954 at 95 % and 0.0041 mmol/L as a limit of detection. The relative standard deviation was less than 1.5 % for 0.005 mmol/L of the analyte (n = 11). The proposed method was validated and applied successfully for the determination of Fosetyl-Al in commercial formulations and can be used as an alternative method for quality control assessment.

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A flow analysis system integrating an optoelectronic detector for the quantitative determination of active ingredients in pharmaceutical formulations

Cited by 16 publications

References 38 publications

Online column preconcentration for speciation and selective determination of Cr(III) in natural water samples using flow injection with chemiluminescence detection

Online column preconcentration for speciation and selective determination of Cr(III) in natural water samples using flow injection with chemiluminescence detection

Investigation and Comparison of Antioxidant Potential of Catechins Present in Green Tea: DFT Study

A Continuous Flow Injection/Indirect Photometric Method for the Detection of Fosetyl Aluminum in Commercial Pesticide Formulations

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