A flow visualization model of duodenogastric reflux after esophagectomy with gastric interposition

Park, Chul Hyun; Lee, Jae Ik; Sung, Jaeyong; Choi, Sunghoon; Ko, Kwang Pil

doi:10.1186/1749-8090-8-192

Cited by 6 publications

(4 citation statements)

References 15 publications

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“…8 In addition, gastric content may readily flow backward into the esophagus in the thoracic cavity due to negative pressure. 9 Mohiuddin and Low described a higher rate of gastric conduit redundancy in the right hemithorax among patients who underwent Ivor-Lewis esophagectomy manifesting as delayed gastric emptying. 10 In our study, we found that intrathoracic location of the conduit plays a role in the development of these inflammatory changes.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Radiologic Evaluation of Microaspirations among Patients after Esophagectomy

Pines

Jacobson

Zheng

et al. 2020

Thorac Cardiovasc Surg

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Objectives Aspirations are common after esophagectomy. Data are lacking regarding its long-term radiological manifestations. The purpose of this study is to determine the incidence and radiological patterns of aspirations among long-term survivors and evaluate their clinical significance. Methods The records of all patients who underwent esophagectomy between October 2003 and December 2011 and survived more than 3 years were reviewed. Preoperative, first routine postoperative, and latest chest computed tomography (CT)scans were reviewed. Imaging studies were reviewed for radiological signs suspicious of aspirations, conduit location, anastomotic site, and maximal intrathoracic diameter. Data regarding patients' complaints during clinic visits were also collected. Results A total of 578 patients underwent esophagectomy during the study period. One-hundred twenty patients met the inclusion criteria. Median follow-up was 83.5 months. Cervical and intrathoracic anastomoses were performed in 103 and 17 patients, respectively. A higher rate of CT findings was found in postoperative imaging (n = 51 [42.5%] vs. n = 13 [10.8%] respectively, p < 0.05). Most of these were found in the lower lobes (61%). A higher rate of lesions was found among patients in whom the conduit was bulging to the right hemithorax compared with totally mediastinal or completely in the right hemithorax (54.5 vs. 35.2% and 34.6%, respectively, p < 0.05). No correlation was found with conduit diameter or anastomotic site. These lesions were more prevalent among patients who complained of reflux or cough during meals (NS). Conclusions A significantly higher rate of new CT findings was found in postoperative imaging of this post-esophagectomy cohort, suggesting a high incidence of aspirations. The locations of the conduit, rather than anastomosis site, seem to play a role in the development of these findings. Further research is needed to evaluate the clinical significance of these findings.

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Section: Discussionmentioning

confidence: 99%

Long-Term Radiologic Evaluation of Microaspirations among Patients after Esophagectomy

Pines

Jacobson

Zheng

et al. 2020

Thorac Cardiovasc Surg

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“…Mechanistically, DGR can be caused by any factor that leads to gastrointestinal motility disorders and anatomical abnormalities, such as major gastrectomy ( 31 ), disruption of gastrointestinal hormone secretion ( 32 ) and autonomic dysfunction ( 33 ). Among them, disorders of gastrointestinal hormone secretion have a greater impact on primary DGR.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the risk factors of duodenogastric reflux in relation to different dietary habits in a Chinese population of the Zhangjiakou area

Peng,

Wang,

et al. 2023

Food & Nutrition Research

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Objective: To explore the risk factors of duodenogastric reflux (DGR) in relation to different dietary habits. Methods: A total of 106 patients with symptoms of DGR who underwent electronic gastroscopy from June 2019 to June 2020 were selected and divided into the DGR group (n = 33) and the non-DGR group (n = 73) according to the diagnosis of bile reflux. Questionnaires were used to collect the basic information and dietary habits of the patients, including age, gender, body mass index, place of residence, comorbidities, dietary composition, salt intake, smoking and drinking consumption. The total bile acid (TBA) and cholesterol (CHO) of the gastric juice were measured using a fully automated biochemical analyser, with an enzyme-linked immunosorbent assay used for the serum cholecystokinin, gastrin and gastrin levels. Univariate analysis and multivariate logistic regression analysis were used to predict the attendant DGR risk factors. Results: There was no significant difference in age or gender between the DGR and the non-DGR groups (P > 0.05). The proportion of patients living in the Bashang region was significantly higher in the DGR group (78.79%) than in the non-DGR group (38.36%) (P < 0.05). The levels of TBA and CHO in the gastric juice and the cholecystokinin and gastrin levels in the serum of the DGR group were higher than those in the non-DGR group, while the serum motilin levels were significantly lower in the DGR group than in the non-DGR group (P < 0.05). The univariate analysis indicated that the proportion of patients with daily consumption of dairy products and fried foods, a high salt intake and smoking and drinking consumption were significantly higher in the DGR than in the non-DGR group (P < 0.05). Conclusion: The daily consumption of dairy products and a preference for fried food are independent risk factors for the occurrence of DGR (odds ratio ≥ 1, P < 0.05).

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“…As a consequence, there has been found up to 20% esophagitis in the cervical esophageal stump during the first year after surgery, and approximately 70% in the seventh year, and the presence of Barrett's esophagus in the cervical stump in up to 27.7% of cases, which is more serious 26,34 . Of course, the destruction of reflux containment mechanisms (loss of inferior esophageal sphincter mechanism, cardia and pylorus), promote mixed reflux (acid and bile), extremely harmful to the esophageal mucosa 36,37 .…”

Section: Discussion Discussion Discussion Discussionmentioning

confidence: 99%

Esophagectomy with gastroplasty in advanced megaesophagus: late results of omeprazole use

Pochini¹,

Gagliardi²,

Júnior³

et al. 2015

Rev. Col. Bras. Cir.

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Objective: To analyze the late results of advanced Chagasic megaesophagus treatment by esophagectomy associated with the use of proton pump inhibitor (omeprazole) as for the incidence of esophagitis and Barrett's esophagus in the remaining stump. Methods : We studied patients with advanced megaesophagus undergoing esophagectomy and transmediastinal esophagogastroplasty. Patients were divided into three groups: A (20) with esophageal replacement by full stomach, without the use of omeprazole; B (20) with esophageal replacement by full stomach, with omeprazole 40 mg/day introduced after the first postoperative endoscopy and maintained for six years; and C (30) with esophageal replacement by gastric tube with use of omeprazole. Dysphagia, weight loss and BMI were clinical parameters we analyzed. Upper gastrointestinal endoscopy was performed in all patients, and determined the height of the anastomosis, the aspect of the mucosa, with special attention to possible injuries arising from gastroesophageal reflux, and the patency of the esophagogastric anastomosis. Results : We studied 50 patients, 28 males (56%) and 22 (44%) females. All underwent endoscopy every year. In the first endoscopy, erosive esophagitis was present in nine patients (18%) and Barrett's esophagus, in four (8%); in the last endoscopy, erosive esophagitis was present in five patients (8%) and Barrett's esophagus in one (2%). When comparing groups B and C, there was no evidence that the manufacturing of a gastric tube reduced esophagitis and Barrett's esophagus. However, when comparing groups A and C, omeprazole use was correlated with reduction of reflux complications such as esophagitis and Barrett's esophagus (p <0.005). Conclusion : The use of omeprazole (40 mg/day) reduced the onset of erosive esophagitis and Barrett's esophagus during the late postoperative period.

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A flow visualization model of duodenogastric reflux after esophagectomy with gastric interposition

Cited by 6 publications

References 15 publications

Long-Term Radiologic Evaluation of Microaspirations among Patients after Esophagectomy

Long-Term Radiologic Evaluation of Microaspirations among Patients after Esophagectomy

Assessment of the risk factors of duodenogastric reflux in relation to different dietary habits in a Chinese population of the Zhangjiakou area

Esophagectomy with gastroplasty in advanced megaesophagus: late results of omeprazole use

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