A fluorescence aptasensor based on controlled zirconium–based MOFs for the highly sensitive detection of T–2 toxin

Zhao, Xudong; Wang, Yu; Li, Jingzhi; Huo, Bingyang; Qin, Yingkai; Zhang, Jingyang; Chen, Mengmeng; Peng, Yuan; Bai, Jintao; Li, Shuang; Gao, Zhixian

doi:10.1016/j.saa.2021.119893

Cited by 35 publications

(5 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A highly sensitive response to T-2 toxin was made possible by the restoration of fluorescence intensity after blocking the energy transfer mechanism. They also observed a strong linear correlation between toxin concentration and the fluorescence intensity [48].…”

Section: Upconverting Nanoparticlesmentioning

confidence: 86%

“…Their findings suggest that the graphene oxide SELEX method was suitable for the screening of aptamers against small molecule toxins, providing a potential application for aptamer-based biosensors. Similarly, Zhao with his team created a fluorescence aptasensor using an aptamer that was tagged with the Cy3-aptamer for the detection of T-2 toxin in beer [48]. The fluorescence of the Cy3-aptamer based on the fluorescence resonance energy transfer (FRET) and photoinduced energy transfer (PET) was quenched by NH 2 -UiO-66.…”

Section: Upconverting Nanoparticlesmentioning

confidence: 99%

See 1 more Smart Citation

Current State of Sensors and Sensing Systems Utilized in Beer Analysis

et al. 2023

View full text Add to dashboard Cite

Beer is one of the most consumed beverages in the world. Advances in instrumental techniques have allowed the analysis and characterization of a large number of beers. However, review studies that outline the methodologies used in beer characterization are scarce. Herein, a systematic review investigating the molecular targets and sensometric techniques in beer characterization was performed following the PRISMA protocol. The study reviewed 270 articles related to beer analysis in order to provide a comprehensive summary of the recent advances in beer analysis, including methods using sensors and sensing systems. The results revealed the use of various techniques that include several technologies, such as nanotechnology and electronics, often combined with scientific data analysis tools. To our knowledge, this study is the first of its kind and provides the reader with a faithful overview of what has been done in the sensor field regarding beer characterization.

show abstract

Section: Upconverting Nanoparticlesmentioning

confidence: 86%

Section: Upconverting Nanoparticlesmentioning

confidence: 99%

Current State of Sensors and Sensing Systems Utilized in Beer Analysis

et al. 2023

View full text Add to dashboard Cite

show abstract

“…To verify the practicability of the aptasensor, soybean, grape and milk were purchased from the supermarket and tested as real food samples. The pretreatment methods of food samples were referred to in previous reports [ 23 , 24 , 25 ]. The actual samples were added 1 nM, 5 nM and 10 nM of OTA, respectively.…”

Section: Methodsmentioning

confidence: 99%

An Alkyne-Mediated SERS Aptasensor for Anti-Interference Ochratoxin A Detection in Real Samples

Wang

Chen

et al. 2022

Foods

View full text Add to dashboard Cite

Avoiding interference and realizing the precise detection of mycotoxins in complex food samples is still an urgent problem for surface-enhanced Raman spectroscopy (SERS) analysis technology. Herein, a highly sensitive and specific aptasensor was developed for the anti-interference detection of Ochratoxin A (OTA). In this aptasensor, 4-[(Trimethylsilyl) ethynyl] aniline was employed as an anti-interference Raman reporter to prove a sharp Raman peak (1998 cm−1) in silent region, which could avoid the interference of food bio-molecules in 600–1800 cm−1. 4-TEAE and OTA-aptamer were assembled on Au NPs to serve as anti-interference SERS probes. Meanwhile, Fe3O4 NPs, linked with complementary aptamer (cApts), were applied as capture probes. The specific binding of OTA to aptamer hindered the complementary binding of aptamer and cApt, which inhibited the binding of SERS probes and capture probes. Hence, the Raman responses at 1998 cm−1 were negatively correlated with the OTA level. Under the optimum condition, the aptasensor presented a linear response for OTA detection in the range of 0.1–40 nM, with low detection limits of 30 pM. In addition, the aptasensor was successfully applied to quantify OTA in soybean, grape and milk samples. Accordingly, this anti-interference aptasensor could perform specific, sensitive and precise detection of OTA in real samples, and proved a reliable reference strategy for other small-molecules detection in food samples.

show abstract

“…Covalent bond isextensively utilized to connect MOFs with nucleic acid stably, there are abundant corresponding chemical groups on MOFs surfaces (Figure 1), and also common to functionalize the surface of MOFs materials, which equipped MOFs NPs with versatile functionalities, such as enhanced system stability, improved cellar uptake, facilitated guest molecular release. [11] As described below, these organic functional groups are typically amines, [12] carboxylic acids, and azides. [13] For example, Mirkin and co-workers exploited the functionality of oligonucleotides appended with dibenzylcyclooctyne and azide-functionalized UiO-66-N 3 via Cu-free, strain-promoted, alkyne click chemistry to develop the 14-540 nm UiO-66-N 3 nanoparticles-nucleic acid conjugates (Figure 2).…”

Section: Covalentinteractionsmentioning

confidence: 99%

Metal‐Organic Frameworks Nanocarriers for Functional Nucleic Acid Delivery in Biomedical Applications

Shang

Chen

et al. 2023

The Chemical Record

View full text Add to dashboard Cite

Metal−organic frameworks (MOFs), a distinctive funtionalmaterials which is constructed by various metal ions and organic molecules, have gradually attracted researchers′ attention from they were founded. In the last decade, MOFs emerge as a biomedical material with potential applications due to their unique properties. However, the MOFs performed as nanocarriers for functional nucleic acid delivery in biomedical applications rarely summarized. In this review, we introduce recent developments of MOFs for nucleic acid delivery in various biologically relevant applications, with special emphasis on cancer therapy (including siRNA, ASO, DNAzyme, miRNA and CpG oligodeoxynucleotides), bioimaging, biosensors and separation of biomolecules. We expect the accomplishment of this review could benefit certain researchers in biomedical field to develop novel sophisticated nanocarriers for functional nucleic acid delivery based on the promising material of MOFs.

show abstract

A fluorescence aptasensor based on controlled zirconium–based MOFs for the highly sensitive detection of T–2 toxin

Cited by 35 publications

References 44 publications

Current State of Sensors and Sensing Systems Utilized in Beer Analysis

Current State of Sensors and Sensing Systems Utilized in Beer Analysis

An Alkyne-Mediated SERS Aptasensor for Anti-Interference Ochratoxin A Detection in Real Samples

Metal‐Organic Frameworks Nanocarriers for Functional Nucleic Acid Delivery in Biomedical Applications

Contact Info

Product

Resources

About