A fluorescent conjugated polymer for trace detection of diamines and biogenic polyamines

Bao, Biqing; Yuwen, Lihui; Zheng, Xiannuo; Weng, Lixing; Zhu, Xiaohui; Zhan, Xiaowei; Wang, Lianhui

doi:10.1039/c0jm01467b

Cited by 76 publications

(40 citation statements)

References 39 publications

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“…In this review, new materials used in FRET are highlighted. Our group used FRET from PFCOOH-BT(5) to diamines and biogenic polyamines to achieve a LOD as low as 2 μM, indicating that PFCOOH-BT(5) can serve as a general and effective chemosensor to detect trace diamines and biogenic polyamines [160]. …”

Section: Biosensorsmentioning

confidence: 99%

Early Lung Cancer Diagnosis by Biosensors

Zhang

Yang

Weng

et al. 2013

IJMS

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Lung cancer causes an extreme threat to human health, and the mortality rate due to lung cancer has not decreased during the last decade. Prognosis or early diagnosis could help reduce the mortality rate. If microRNA and tumor-associated antigens (TAAs), as well as the corresponding autoantibodies, can be detected prior to clinical diagnosis, such high sensitivity of biosensors makes the early diagnosis and prognosis of cancer realizable. This review provides an overview of tumor-associated biomarker identifying methods and the biosensor technology available today. Laboratorial researches utilizing biosensors for early lung cancer diagnosis will be highlighted.

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Section: Biosensorsmentioning

confidence: 99%

Early Lung Cancer Diagnosis by Biosensors

Zhang

Yang

Weng

et al. 2013

IJMS

Self Cite

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“…It is important to monitor the presence of this compound to minimize both occupational and environmental concerns.F luorescence, as as imple and effective real-time analytical method, has been actively investigated fort he detection of amines,d iamines, and polyamines. [2,3] However, fluorescent sensors capable of discriminating 1,2-diamines from other diamines are rare. [4] The reversible reaction of the highly electrophilic trifluoromethyl ketones has been actively pursued form olecular recognitiono fa mines.…”

Section: Introductionmentioning

confidence: 99%

Fluorescent Recognition of 1,2‐Diamines by a 1,1′‐Binaphthyl‐Based Trifluoromethyl Ketone

Sheng

Chen

et al. 2016

Chemistry A European J

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The fluorescent responses of a 1,1'-binaphthol (BINOL)-based trifluoromethyl aryl ketone toward a variety of amines have been studied. The aliphatic 1,2-diamines, especially ethylenediamine, can greatly enhance the fluorescence of this compound, but under the same conditions, other mono- and diamines cause much smaller fluorescent responses. This compound can be used as a fluorescent sensor for the detection of ethylenediamine at concentrations over micromolar levels. UV absorption and NMR spectroscopic methods have been used to study the interactions of the sensor with ethylenediamine. These studies have demonstrated that the trifluoromethyl ketone of the sensor reacts with ethylenediamine much more favorably than with other amines. The hydroxyl groups of the sensor and those of the hemiaminal adducts formed in the presence of the amines are important for the highly selective fluorescent response.

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“…On the other hand, aqueous solubility of CPs is essential for interfacing with biological substrates such as proteins and DNA, and this property is usually achieved by the modification of the conjugated backbone with charged functionalities as pendant groups 6, 7. These conjugated polyelectrolytes (CPEs) are attractive materials because their optoelectronic properties can be greatly perturbed by the local electrochemical environment 8–18. Electrostatic interaction between CPEs and negatively charged DNA can be coordinated to design sequence‐specific DNA assays 19–25…”

Section: Introductionmentioning

confidence: 99%

New Water‐Soluble Cationic Poly(p‐phenylenevinylene) Derivative: the Interaction with DNA and Selective Fluorescence Enhancement Induced by ssDNA

Zhang¹,

Xu²,

Qin³

et al. 2013

Macromol. Rapid Commun.

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A new cationic cyano-substituted poly(p-phenylenevinylene) (N-CNPPV) is synthesized by Knoevenagel condensation. The water-soluble polymer shows different emission spectra in different solvents and displays unique fluorescent behaviors in the mixed solvents of water and THF. The new polymer can form a complex with ssDNA by adopting a more planar conformation, exhibiting red shift of emission wavelength and enhancement of fluorescence intensity. By investigating the fluorescent response of N-CNPPV to various surfactants, we demonstrate that the hydrophobic interaction and electrostatic interaction result in the selective response of N-CNPPV to ssDNA. This is the first report on selective fluorescence enhancement of conjugated polyelectrolyte induced by ssDNA.

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A fluorescent conjugated polymer for trace detection of diamines and biogenic polyamines

Cited by 76 publications

References 39 publications

Early Lung Cancer Diagnosis by Biosensors

Early Lung Cancer Diagnosis by Biosensors

Fluorescent Recognition of 1,2‐Diamines by a 1,1′‐Binaphthyl‐Based Trifluoromethyl Ketone

New Water‐Soluble Cationic Poly(p‐phenylenevinylene) Derivative: the Interaction with DNA and Selective Fluorescence Enhancement Induced by ssDNA

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