A folic acid conjugated silica–titania porous hollow nanosphere for improved topical photodynamic therapy

Jang, Yoonsun; Kim, Sojin; Oh, Wan‐Kyu; Kim, Chanhoi; Lee, Inkyu; Jang, Jyongsik

doi:10.1039/c4cc07457b

Cited by 12 publications

(11 citation statements)

References 18 publications

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“…21,23,59 In the case of hollow structures, possible applications are drug delivery, nanocages for encapsulation, and nanoreactors for material synthesis. 29,60,61 The 1D metal oxide structure can be applied as a building block for nanodevices, provide mechanical strength by the overlapping of materials, and act as an electrical pathway. 4,6,62…”

Section: Various Intrinsic Advantages Of Hst Materialsmentioning

confidence: 99%

“…E-mail: jsjang@plaza.snu.ac.kr; Tel: +82 2 880 7069 † Electronic supplementary information (ESI) available: (1) SEM micrographs of characteristics such as hollow spaces and increased porosity. 28,29 Synergistic effects from the methods discussed so far can be achieved through a combination of controlling the templated structure, adding metal oxides, and introducing porosity. Although, there is few studies addressing the fabrication of hollow SiO 2 rod-like material or hollow TiO 2 bers, but there were drawbacks of complex experimental procedures and unevenly structured nal products.…”

Section: Introductionmentioning

confidence: 99%

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Fabrication of a silica/titania hollow nanorod and its electroresponsive activity

et al. 2017

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In this study, a 1D oriented hollow SiO 2 /TiO 2 (HST) rod-like material was successfully fabricated via a sequential combination of sol-gel use, TiO 2 incorporation, and a sonication-mediated etching and redeposition method. This carefully manipulated new material has numerous advantageous physical and intrinsic properties, such as increased surface area, pore volume, interfacial polarization, and dielectric properties introduced from each synthetic step. The synthesized HST rod was adopted as an electrorheological (ER) material for practical examination of these characteristics. The HST rod materials exhibited 1.5-and 3-fold higher ER performance than a non-metal SiO 2 rod and a non-hollow SiO 2 /TiO 2 core/shell (ST/CS) rod, which are interim synthetic steps. Moreover, the HST rod exhibited remarkable 6-fold increased ER efficiency relative to a sphere-shaped hollow SiO 2 /TiO 2 particle synthesized using a similar experimental method. These notable enhancements in ER performance are attributed to incorporation of the experimentally designed characteristics of the HST rod: 1D structure, metal oxide incorporation, and creation of a hollow cavity. For future study, we expect that these versatile HST rod materials can be applied in a range of fields including drug delivery, photo-catalysis, and as building blocks.SiO 2 rod, ST/CS rod, and HST rod (L/D ¼ 3), (2) TEM micrographs HCl untreated and calcined SiO 2 rod and resulting HST rod, (3) TEM micrographs of shell thickness controlled HST rod, (4) TEM micrographs of SiO 2 rod, ST/CS rod, and HST materials with varying aspect ratio (L/D ¼ 1, 2, 6), (5) low-magnied TEM micrographs of various HST materials (L/D ¼ 1, 2, 6), (6) physical parameters of various HST materials, (7) porosity, pore volume, and BET surface area of HST rod (L/D ¼ 3), (8) EDS analysis of SiO 2 rod, ST/CS rod, and HST rod (L/D ¼ 3), (9) STEM elemental mapping of SiO 2 rod (L/D ¼ 3), (10) FT-IR spectra and XRD pattern of SiO 2 rod, ST/CS rod, and HST rod (L/D ¼ 3), (11) FT-IR spectra of HCl treated and untreated SiO 2 rod, (12) atomic compositions of various HST materials (L/D ¼ 1, 2, 6), (13) shear stress of HST material-based ER uids with varying aspect ratio (L/D ¼ 1, 2, 6), (14) dielectric properties of HST sphere. See

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Section: Various Intrinsic Advantages Of Hst Materialsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fabrication of a silica/titania hollow nanorod and its electroresponsive activity

et al. 2017

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“…One of the alternative approach is to use metal radionuclide including 68 Ga (t 1/2 = 68 min, β + = 89% and electron capture (EC) = 11%), which can be obtained easily from 68 Ge/ 68 Ga generator without the serve of cyclotron. 8 [20][21][22] .…”

Section: Introductionmentioning

confidence: 99%

In VitroPET/MRI Diagnosis and Targeted Chemotherapy for Cancer Using Radiolabeled Nanoprobe : A Theragnostic Approach

Cho

Moon

Raj

et al. 2016

Bulletin Korean Chem Soc

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complex. The average loading efficiency of DOX was 35% for NFHFCNP and 41% for HFCNP, respectively. In drug release profile, the release rate of DOX from the nanocomposite was increased with respect to time. The cell lines, KB and A549 treated with 68 Ga(NF)HFCNP showed high cell viability and excellent cell uptake. Meanwhile, the DOX-loaded nanocomposites exhibit high cytotoxicity toward these cell lines. These properties make 68 Ga(NF)HFCNP nanocomposite as a potential dual theragnostic probe for PET/MRI and targeted chemotherapy for cancer cells.

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“…PDT uses a photosensitizer (PS) that, internalized into a cancer cell, is stimulated by irradiation to trigger cell damage and death. PS is a light‐sensitive dye that is stimulated by a specific wavelength of light and generates reactive oxygen species (ROS) . Excess ROS production can induce serious damage to malignant cells .…”

Section: Introductionmentioning

confidence: 99%

Graphene Oxide Wrapped SiO₂/TiO₂ Hollow Nanoparticles Loaded with Photosensitizer for Photothermal and Photodynamic Combination Therapy

Jang

Kim

Lee

et al. 2017

Chemistry A European J

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Graphene oxide (GO) enwrapped SiO /TiO hollow nanoparticles (GO-HNP) are synthesized by the Stöber method and used as a nanocarrier for loading protoporphyrin IX (PpIX). The synthesized nanoparticle has high dispersibility and high uniformity in diameter (ca. 50 nm). Furthermore, this nanoparticle shows λ=808 nm laser induced PpIX release properties (photoinduced "on-off" drug-release system). GO-HNP-PpIX is employed for inducing both photothermal therapy (PTT) and photodynamic therapy (PDT). The synergic effect of PTT and PDT exhibits powerful anticancer properties. When cancer cells are treated with GO-HNP-PpIX and irradiated with both visible light and a NIR laser, the cell viability drops dramatically to 2.5 %, which is an anticancer effect approximately 13 times higher than that obtained in a previous study. Moreover, no significant cell damage has been observed under λ=808 nm laser irradiation. The GO-HNP-PpIX system suggests an external stimuli-responsive efficient anticancer treatment effect toward human breast cancer cells.

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A folic acid conjugated silica–titania porous hollow nanosphere for improved topical photodynamic therapy

Cited by 12 publications

References 18 publications

Fabrication of a silica/titania hollow nanorod and its electroresponsive activity

Fabrication of a silica/titania hollow nanorod and its electroresponsive activity

In VitroPET/MRI Diagnosis and Targeted Chemotherapy for Cancer Using Radiolabeled Nanoprobe : A Theragnostic Approach

Graphene Oxide Wrapped SiO₂/TiO₂ Hollow Nanoparticles Loaded with Photosensitizer for Photothermal and Photodynamic Combination Therapy

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A folic acid conjugated silica–titania porous hollow nanosphere for improved topical photodynamic therapy

Cited by 12 publications

References 18 publications

Fabrication of a silica/titania hollow nanorod and its electroresponsive activity

Fabrication of a silica/titania hollow nanorod and its electroresponsive activity

In VitroPET/MRI Diagnosis and Targeted Chemotherapy for Cancer Using Radiolabeled Nanoprobe : A Theragnostic Approach

Graphene Oxide Wrapped SiO2/TiO2 Hollow Nanoparticles Loaded with Photosensitizer for Photothermal and Photodynamic Combination Therapy

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Graphene Oxide Wrapped SiO₂/TiO₂ Hollow Nanoparticles Loaded with Photosensitizer for Photothermal and Photodynamic Combination Therapy