A follow-up study of environmental and biologic determinants of fertility among 430 danish first-pregnancy planners: Design and methods

Bonde, Jens Peter; Hjøllund, Niels Henrik; Jensen, Tina Kold; Ernst, Erik; Kolstad, Henrik A; Henriksen, Tine Brink; Giwercman, Aleksander; Skakkebæk, Niels E.; Andersson, Anna‐Maria; Olsen, Jørn

doi:10.1016/s0890-6238(97)00096-8

Cited by 99 publications

(70 citation statements)

References 13 publications

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“…The couples were enrolled when they discontinued birth control, and they were followed for 6 menstrual cycles or until a pregnancy was recognized by the family practitioner. A detailed description of the study has been published elsewhere (16). The present study is based on pregnancies that occurred during the follow-up period of 6 menstrual cycles.…”

Section: Methodsmentioning

confidence: 99%

“…Urinary human chorionic gonadotrophic hormone (hCG) was measured in a time-resolved immunofluorometric assay for serum hCG (Delfia, Wallac, Finland). The method is specific for intact hCG and was validated for measurements of hCG in urine (16). In a negative reference group of 12 women who had not had intercourse during the previous 2 months, the urinary hCG was less than 0.5 IUI1 in all the samples.…”

Section: Detection Of Spontaneous Abortionmentioning

confidence: 99%

See 1 more Smart Citation

Male-mediated spontaneous abortion among spouses of stainless steel welders

Hjollund¹,

Bonde²,

Jensen³

et al. 2000

Scand J Work Environ Health

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Section: Methodsmentioning

confidence: 99%

Section: Detection Of Spontaneous Abortionmentioning

confidence: 99%

Male-mediated spontaneous abortion among spouses of stainless steel welders

Hjollund¹,

Bonde²,

Jensen³

et al. 2000

Scand J Work Environ Health

Self Cite

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“…W e estimate that 10-20% of the eligible couples participated. A detailed description of the cohort and design has been given elsewhere (12).…”

Section: Methodsmentioning

confidence: 99%

“…First-morning urine samples from days 1 to 10 in each menstrual cycle, starting the first morning with menstrual bleeding, were stored in a freezer for the determination of human choriongonadotropic hormone, which indicates early embryonic loss (12). Information on spontaneous abortion in clinically recognized pregnancies was collected by postal questionnaire or interview 1 year after the 6-cycle follow-up was terminated.…”

Section: Methodsmentioning

confidence: 99%

Job strain and time to pregnancy

Hjollund¹,

Jensen²,

Bonde³

et al. 1998

Scand J Work Environ Health

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Objectives The association between fertility and job strain defined as high job demands and low job control has not previously been studied. A follow-up study was conducted with prospective collection of information on job strain among women, achievement of pregnancy, and potential confounding variables. Methods A total of 297 Danish couples without previous reproductive experience was followed for a maximum of 6 menstrual cycles from termination of birth control until pregnancy. Job demand and job control were measured by a questionnaire developed by Karasek and his co-workers. Results The odds ratio and 95% confidence interval (95% CI) for conception per menstrual cycle for women with high job strain was 0.9 (95% CI 0.5-1.5) when compared with that of women in low-strain jobs. Only in secondary analyses restricted to couples with no suspected competitive causes of reduced fertility was a statistically significant reduced odds found for women with high-strain jobs compared with all otherjobs. C O~C~U S~O~S The main finding of this study did not corroborate a hypothesis of a substantial detrimental effect of job strain on fecundability.

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“…The men provided a semen sample (n = 419). Eight men (1.9%) had azoospermia and were excluded (11,12).…”

Section: Danish Menmentioning

confidence: 99%

Semen quality among Danish and Finnish men attempting to conceive. The Danish First Pregnancy Planner Study Team

Jensen¹,

Vierula²,

Hjøllund³

et al. 2000

Eur J Endocrinol

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Objective: To assess differences in semen quality between similar populations from Denmark and Finland. Design: Comparison of semen quality between 221 Finnish men (of whom 115 had no proven fertility) and 411 Danish men with no proven fertility in two follow-up studies among normal couples trying to conceive. Methods: In Finland male partners of couples without experienced infertility attempting to conceive were recruited through advertisements in local newspapers from 1984 to 1986. From 1992 to 1995 Danish men who lived with a partner and who had not attempted to achieve a pregnancy previously were recruited through their union when they discontinued birth control. All semen analyses were performed in accordance with the World Health Organization guidelines. Results: Median sperm concentration, total sperm count and the percentage of morphologically normal spermatozoa were significantly higher among the Finnish men without proven fertility (104.0 million/ml, 304.0 million and 58% respectively) compared with the Danish men (53.0 million/ml, 140.8 million, and 41% respectively). Sperm concentration was 105.7% (95% confidence interval (CI) 58.1%-167.6%) and total sperm count was 127.4% (95% CI 71.4%-201.6%) higher among Finnish men without proven fertility than among Danish men after control for confounders. Conclusions: Some, but hardly all, of the observed difference in semen quality may be explained by differences in recruitment procedures, selection of the men and by methodological differences in semen analysis between the two countries. Also a birth cohort effect may explain some of the differences between countries as the Finnish men were recruited 11 years before the Danish men. Therefore, follow-up studies with identical recruitment and selection of men from the two countries are needed.

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A follow-up study of environmental and biologic determinants of fertility among 430 danish first-pregnancy planners: Design and methods

Cited by 99 publications

References 13 publications

Male-mediated spontaneous abortion among spouses of stainless steel welders

Male-mediated spontaneous abortion among spouses of stainless steel welders

Job strain and time to pregnancy

Semen quality among Danish and Finnish men attempting to conceive. The Danish First Pregnancy Planner Study Team

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