A follow‐up study of laboratory animal exposed workers: The influence of atopy for the development of occupational asthma

Sjöstedt, Lars; Willers, Stefan; Ørbæk, Palle

doi:10.1002/ajim.4700240410

Cited by 29 publications

(16 citation statements)

References 16 publications

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“…These animals can determine occupational sensitization in laboratory personnel (10-40% of the exposed subjects; 449) and in children of parents occupationally exposed to mice, rats and hamsters (450)(451)(452). Rodent allergens are common in houses either from pets or due to contamination by mouse urine in deprived areas.…”

Section: Other Mitesmentioning

confidence: 99%

See 1 more Smart Citation

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Bousquet¹,

Khaltaev²,

Cruz³

et al. 2008

Allergy

3,867

1,761

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Section: Other Mitesmentioning

confidence: 99%

“…The second consists of rhinitis leading progressively to asthma with positive prick tests. Atopy (451,452) and active smoking (583) represent a risk for the development of laboratory animal allergy. Prick tests are useful diagnostically only in the latter.…”

Section: Other Mitesmentioning

confidence: 99%

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Bousquet¹,

Khaltaev²,

Cruz³

et al. 2008

Allergy

3,867

1,761

View full text Add to dashboard Cite

“…Atopy increases the risk of development of occupational asthma due to sensitization to the high molecular weight allergens [22][23][24][25]. It was observed in bakers and farmers exposed to flowers and animals allergens [26][27][28]. There is no sufficiently proved relationship between atopy and occupational sensitization in the case of allergy to wood dust allergens, which are classified as the low molecular weight allergens.…”

Section: A S E R E P O R T P Krawczyk-szulc Et Almentioning

confidence: 99%

Occupational asthma caused by samba (Triplochiton scleroxylon) wood dust in a professional maker of wooden models of airplanes: A case study

Krawczyk-Szulc¹,

Wiszniewska²,

Pałczyński³

et al. 2014

International Journal of Occupational Medicine and Environmental Health

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Objectives: Wood dust is a known occupational allergen that may induce, in exposed workers, respiratory diseases including asthma and allergic rhinitis. Samba (obeche, Triplochiton scleroxylon) is a tropical tree, which grows in West Africa, therefore, Polish workers are rarely exposed to it. This paper describes a case of occupational asthma caused by samba wood dust. Material and Methods: The patient with suspicion of occupational asthma due to wood dust was examined at the Department of Occupational Diseases and Clinical Toxicology in the Nofer Institute of Occupational Medicine. Clinical evaluation included: analysis of occupational history, skin prick tests (SPT) to common and occupational allergens, determination of serum specific IgE to occupational allergens, serial spirometry measurements, metacholine challenge test and specific inhalation challenge test with samba dust. Results: SPT and specific serum IgE assessment revealed sensitization to common and occupational allergens including samba. Spirometry measurements showed mild obstruction. Metacholine challenge test revealed a high level of bronchial hyperactivity. Specific inhalation challenge test was positive and cellular changes in nasal lavage and induced sputum confirmed allergic reaction to samba. Conclusions: IgE mediated allergy to samba wood dust was confirmed. This case report presents the first documented occupational asthma and rhinitis due to samba wood dust in wooden airplanes model maker in Poland.

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“…The study group of 26 technicians with LAA has been well defined and was investigated also in a follow-up study [10,12], They fulfilled the criteria of an outbred highly po lymorphic group, selected among 101 individuals, on clin ical and diagnostic grounds.…”

Section: Serum Ige and Igg Subclass Levelsmentioning

confidence: 99%

Development of Allergy to Laboratory Animals Is Associated with Particular Gm and HLA Genes

Oxelius

Sjöstedt²,

Willers

et al. 1996

Int Arch Allergy Immunol

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To find out whether IgG genes are involved in atopy we studied 26 of 101 laboratory technicians who had developed laboratory animal allergy (LAA). The genes for the constant region of the heavy chains of IgG subclasses were analyzed by serum Gm allotypes, representing products on allelic level of the IGHCG1, IGHCG2 and IGHCG3 on chromosome 14q32. There was a significantly increased frequency of the Gm(f,f;n,n;b,b) genotype (57.7 instead of 22.3%, p < 0.001) representing IgG1, IgG2 and IgG3 molecules and in particular increased frequency of Gm genotypes with the homozygous expression of G2m (nn) (69.2 instead of 27.4%, p < 0.001) and of the Gm(fnb) haplotype (75 instead of 44.8%, p < 0.001) compared to a normal Caucasian population. An increased HLA-DR4 content of the LAA group (61.5 instead of 33.7%, p < 0.01) was further investigated for Gm allotypes. Among 16 HLA-DR4 LAA individuals, the Gm(f,f;n,n;b,b) genotype (56.3 instead of 22.3%, p < 0.01) and the Gm genotypes with the homozygous expression G2m(n, n) (62.6 instead of 27.4%, p < 0.01) dominated. However, the HLA-DR4 frequency among Gm(f,f;n,n;b,b) of LAA patients did not deviate from the frequency of healthy individuals of the same Gm genotype. The increased frequency of HLA-DR4 antigen in LAA patients might be due to its association to the Gm(f,f;n,n;b,b) genotype. This study supports the following concept: the susceptibility of developing LAA is associated with Gm allotypes Glm(f) expressed from IGHCG1, G2m(n) from IGHCG2 and G3m(b) from IGHCG3 on both alleles situated close to IGHCE on chromosome 14q32. The association of LAA to Gm allotypes [Gm(f,f;n,n;b,b)] expressed from chromosome 14q32 and of HLA class II antigens (HLA-DR4) expressed from chromosome 6p21.3 further confirms the polygenic inheritance of the immune response in atopy.

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A follow‐up study of laboratory animal exposed workers: The influence of atopy for the development of occupational asthma

Cited by 29 publications

References 16 publications

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Occupational asthma caused by samba (Triplochiton scleroxylon) wood dust in a professional maker of wooden models of airplanes: A case study

Development of Allergy to Laboratory Animals Is Associated with Particular Gm and HLA Genes

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