Journal of Chronic Diseases

1971

DOI: 10.1016/0021-9681(71)90105-6

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A follow-up study of the commission on chronic illness morbidity survey in baltimore —IV. Factors influencing mortality from stroke and arteriosclerotic heart disease (1954–1967)

Lewis H. Kuller

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Cited by 29 publications

(15 citation statements)

References 19 publications

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“…Five studies were excluded from the statistical analysis because of insufficient data (21)(22)(23)(24)(25). These studies did not calculate separate relative risks for the 2 sexes and did not provide enough data for them to be extracted.…”

Section: Discussionmentioning

confidence: 99%

“…RESULTS -Sixteen prospective cohort studies were eligible for this analysis (5,6,(8)(9)(10)13,18,(21)(22)(23)(24)(25)(26)(27)(28)(29); 5 studies, as described above, were excluded from further consideration because of missing data. Important characteristics of all of the studies are listed in Tables 1 and 2.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Impact of diabetes on coronary artery disease in women and men: a meta-analysis of prospective studies.

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et al. 2000

Diabetes Care

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A meta-analysis of prospective studies O R I G I N A L A R T I C L EOBJECTIVE -Women are at a much lower risk of coronary disease mortality than men are. It is widely believed that diabetes "erases" this female advantage, increasing the risk of heart disease much more in women than in men. In reality, the extent of this increased risk is controversial, with studies showing conflicting results and wide confidence intervals. Clarification of this issue has implications for the pathogenesis of coronary disease, and for public health efforts to reduce coronary disease in women.RESEARCH DESIGN AND METHODS -We performed a meta-analysis to calculate a summary estimate of the relative risk of coronary death among women with diabetes as compared to those without. For comparison, we also calculated the analogous risk among men. All prospective cohort studies containing both men and women, and both patients with and without diabetes, were examined. Sixteen studies were identified; 10 had sufficient data for statistical analysis.RESULTS -After combining studies that adjusted for other cardiac risk factors, the relative risk of coronary death from diabetes was 2.58 (95% CI 2.05-3.26) for women and 1.85 (1.47-2.33) for men. This difference is statistically significant (P = 0.045). Other sensitivity analyses did not change these estimates appreciably.CONCLUSIONS -The impact of diabetes on the risk of coronary death is significantly greater for women than men. Further research is required to explain this clinically meaningful difference between the sexes. Diabetes Care 23:962-968, 2000

“…Five studies were excluded from the statistical analysis because of insufficient data (21)(22)(23)(24)(25). These studies did not calculate separate relative risks for the 2 sexes and did not provide enough data for them to be extracted.…”

Section: Discussionmentioning

confidence: 99%

“…RESULTS -Sixteen prospective cohort studies were eligible for this analysis (5,6,(8)(9)(10)13,18,(21)(22)(23)(24)(25)(26)(27)(28)(29); 5 studies, as described above, were excluded from further consideration because of missing data. Important characteristics of all of the studies are listed in Tables 1 and 2.…”

Section: Discussionmentioning

confidence: 99%

Impact of diabetes on coronary artery disease in women and men: a meta-analysis of prospective studies.

¹

,

²

,

³

et al. 2000

Diabetes Care

View full text Add to dashboard Cite

A meta-analysis of prospective studies O R I G I N A L A R T I C L EOBJECTIVE -Women are at a much lower risk of coronary disease mortality than men are. It is widely believed that diabetes "erases" this female advantage, increasing the risk of heart disease much more in women than in men. In reality, the extent of this increased risk is controversial, with studies showing conflicting results and wide confidence intervals. Clarification of this issue has implications for the pathogenesis of coronary disease, and for public health efforts to reduce coronary disease in women.RESEARCH DESIGN AND METHODS -We performed a meta-analysis to calculate a summary estimate of the relative risk of coronary death among women with diabetes as compared to those without. For comparison, we also calculated the analogous risk among men. All prospective cohort studies containing both men and women, and both patients with and without diabetes, were examined. Sixteen studies were identified; 10 had sufficient data for statistical analysis.RESULTS -After combining studies that adjusted for other cardiac risk factors, the relative risk of coronary death from diabetes was 2.58 (95% CI 2.05-3.26) for women and 1.85 (1.47-2.33) for men. This difference is statistically significant (P = 0.045). Other sensitivity analyses did not change these estimates appreciably.CONCLUSIONS -The impact of diabetes on the risk of coronary death is significantly greater for women than men. Further research is required to explain this clinically meaningful difference between the sexes. Diabetes Care 23:962-968, 2000

“…Historically, one of the widely accepted definitions of chronic disease was the one proposed in 1957 by the Commission on Chronic Illness at Cambridge, which included all diseases with one or several of the following features -permanent, generating residual incapacity/disability, are caused by irreversible pathological changes, require special training of the patient towards recovery, or may require extended monitoring, observation or care provision periods (Kuller Tonascia 1971). In turn, WHO subscribes to the definition of chronic disease, considering that, in general, "diseases are slow in progression, long in duration, and they require medical treatment (WHO 2013).…”

Section: Responsibility Of the Conference Organization Committeementioning

confidence: 99%

Quality of life and chronic disease in patients receiving primary health care

et al. 2016

European Proceedings of Social &Amp; Behavioural Sciences

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Problem Statement: Chronic disease entails physical, psychological and social issues with a decrease in the quality of life. The assessment of QoL has been applied as indicator in patients with chronic diseases. Research Questions: What is the quality of life in patients with chronic disease? What are the socio-demographic variables that influence the quality of life in patients? Purpose: To assess the quality of life in patients suffering from chronic disease and identify socio-demographic variables which influence the quality of life of patients suffering from chronic disease. Research Methods: We conducted a cross-sectional analytical study using a sample composed of 228 users (134 females) from a Family Health Unit in the municipality of Viseu. Data collection was made by means of a questionnaire, consisting of sociodemographic variables, the SF-12 scale and the existence of chronic disease was assessed through the questions -"Do you currently suffer from any chronic disease?"; "If so, which one(s)?". Findings: The most common chronic diseases were hypertension (59.9%). Female patients with a chronic disease reported worse physical functioning, role-physical and role-emotional; increased bodily pain and better quality of life regarding general health. Male patients showed worse role-physical, increased bodily pain and vitality. Sociodemographic variables which were associated with quality of life were area of residence, academic qualifications and work situation. Conclusion: Chronic disease affects quality of life negatively. Quality of life in both patients groups was associated with socio-demographic variables. Health-related quality of life is an essential issue and should be considered as a priority in health policies.

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Diabetes mellitus is associated with an increased risk of atherosclerosis [1]. Atherosclerosis is responsible for the increased rate of coronary heart disease, cerebrovascular disease and peripheral artery disease typical of diabetes mellitus [2±13].

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mentioning

confidence: 99%

Early impairment of large artery structure and function in Type I diabetes mellitus

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et al. 1999

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Diabetes mellitus is associated with an increased risk of atherosclerosis [1]. Atherosclerosis is responsible for the increased rate of coronary heart disease, cerebrovascular disease and peripheral artery disease typical of diabetes mellitus [2±13]. It is not, however, well established how early alterations in large artery function, that may preceed the appearance and favour the progression of atherosclerotic lesions, i. e. a reduced arterial distensibility, occur in diabetic patients [14±16]. This is because most studies on arterial distensibility have been done in Type II (non-insulindependent) diabetes mellitus, where it is difficult to separate the arterial stiffening due to abnormalities Diabetologia (1999) Abstract Aims/hypothesis. Diabetes mellitus is associated with an increased incidence of atherosclerosis. How early functional and structural alterations of large arteries that may preceed atherosclerosis occur in the course of this disease has, however, never been conclusively documented. Methods. We evaluated arterial wall distensibility in the radial artery, common carotid artery and abdominal aorta in 133 patients (aged 35.4 ± 0.9 years, means ± SEM) with Type I (insulin-dependent) diabetes mellitus and no macrovascular complications. Arterial distensibility was derived from continuous measurements of arterial diameter through echotracking techniques and use of either the Langewouters (radial artery) or the Reneman (carotid artery and aorta) formula. The same echotracking techniques enabled us to obtain radial artery and carotid artery wall thickness. Data were compared with those from 70 age-matched normotensive control subjects. Results. In diabetic patients arterial distensibility was consistently less (p < 0.01) than in control subjects, the reduction averaging 26 %, 14 % and 25 % for the radial artery, carotid artery and aorta, respectively. This was accompanied by an increase (p < 0.01) in both radial and carotid artery wall thickness. The changes were more pronounced in patients with microalbuminuria, retinopathy or neuropathy or both. They were evident also in those without microvascular complications. This was the case also when subjects in whom diabetes was associated with hypertension (n = 30) were excluded from data analysis. Carotid and aortic wall abnormalities showed a relation with the duration of disease and blood pressure whereas radial artery abnormalities showed a relation with glycated haemoglobin. Conclusion/interpretation. Type I diabetes is characterised by diffuse arterial wall stiffening and thickening which progress with the severity of the disease but can clearly be seen also in the absence of any diabetic-related complication. This suggests that in diabetes stiffening and thickening are an early marker of vascular damage. [Diabetologia (1999) 42: 987± 994]

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