A forebrain neural substrate for behavioral thermoregulation

Jung, Sieun; Lee, Myungsun; Kim, Dong-Yoon; Son, Celine; Ahn, Benjamin Hyunju; Heo, Gyuryang; Park, Junkoo; Kim, Minyoo; Park, Han-Eol; Koo, Dong-Jun; Park, Jong Hwi; Lee, Sang Eun; Choe, Han Kyoung; Kim, Sung-Yon

doi:10.1016/j.neuron.2021.09.039

Cited by 27 publications

(18 citation statements)

References 86 publications

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“…1B ). This experimental design enabled ratiometric measurements of GCaMP activity, yielding signals minimally compromised by motion artifacts and ambient light [ 62 , 63 ].…”

Section: Resultsmentioning

confidence: 99%

“…Fiber photometry recordings were performed as previously described [ 62 , 63 ]. Briefly, excitation lights from 470-nm and 405-nm LEDs (Thorlabs, M470F3/M405F1) that were sinusoidally modulated by the RZ5P processor (Tucker Davis Technologies) at 211 Hz and 531 Hz, respectively, were delivered to the target region of mice via a low-autofluorescence fiberoptic patch cord and cannula (Doric Lenses, 400 μm-core, 0.48 NA).…”

Section: Methodsmentioning

confidence: 99%

“…All data were analyzed with custom-written Matlab (Mathworks) code. The photometry signal was analyzed as previously described [ 62 , 63 ]. Briefly, data were low-pass filtered at 2 Hz, downsampled to 100 Hz, and a linear function scaled the 405-nm signal to the 470-nm signal to obtain the fitted 405-nm signal.…”

Section: Methodsmentioning

confidence: 99%

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Lateral Septum Somatostatin Neurons are Activated by Diverse Stressors

Kim

Park

et al. 2022

Exp Neurobiol

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The lateral septum (LS) is a forebrain structure that has been implicated in a wide range of behavioral and physiological responses to stress. However, the specific populations of neurons in the LS that mediate stress responses remain incompletely understood. Here, we show that neurons in the dorsal lateral septum (LSd) that express the somatostatin gene (hereafter, LSd Sst neurons) are activated by diverse stressors. Retrograde tracing from LSd Sst neurons revealed that these neurons are directly innervated by neurons in the locus coeruleus (LC), the primary source of norepinephrine well-known to mediate diverse stress-related functions in the brain. Consistently, we found that norepinephrine increased excitatory synaptic transmission onto LSd Sst neurons, suggesting the functional connectivity between LSd Sst neurons and LC noradrenergic neurons. However, optogenetic stimulation of LSd Sst neurons did not affect stress-related behaviors or autonomic functions, likely owing to the functional heterogeneity within this population. Together, our findings show that LSd Sst neurons are activated by diverse stressors and suggest that norepinephrine released from the LC may modulate the activity of LSd Sst neurons under stressful circumstances.

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“…1B ). This experimental design enabled ratiometric measurements of GCaMP activity, yielding signals minimally compromised by motion artifacts and ambient light [ 62 , 63 ].…”

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Lateral Septum Somatostatin Neurons are Activated by Diverse Stressors

Kim

Park

et al. 2022

Exp Neurobiol

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“…Mammalian newborns are poikilotherms, and during this period only the BAT is recruitable for thermogenesis (Cannon and Nedergaard, 2004 ). The second thermoregulatory response implies a behavioral voluntary thermoregulation response using various behavioral strategies to allow mammals to stay as much as possible in a thermoneutral environment (Almeida et al, 2015 ; Jung et al, 2022 ). It has been shown recently that such behavior involves the lateral hypothalamus (LH) (Jung et al, 2022 ).…”

Section: Part 1: Ot Effects On Temperature Sensing and Regulationmentioning

confidence: 99%

Modulation of the thermosensory system by oxytocin

Zayan

Prato

Muscatelli

et al. 2023

Front. Mol. Neurosci.

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Oxytocin (OT) is a neurohormone involved early in neurodevelopment and is implicated in multiple functions, including sensory modulation. Evidence of such modulation has been observed for different sensory modalities in both healthy and pathological conditions. This review summarizes the pleiotropic modulation that OT can exercise on an often overlooked sensory system: thermosensation. This system allows us to sense temperature variations and compensate for the variation to maintain a stable core body temperature. Oxytocin modulates autonomic and behavioral mechanisms underlying thermoregulation at both central and peripheral levels. Hyposensitivity or hypersensitivity for different sensory modalities, including thermosensitivity, is a common feature in autism spectrum disorder (ASD), recapitulated in several ASD mouse models. These sensory dysregulations occur early in post-natal development and are correlated with dysregulation of the oxytocinergic system. In this study, we discussed the potential link between thermosensory atypia and the dysregulation of the oxytocinergic system in ASD.

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“…Fos expression in these neurons was not increased after fasting 69 , implying that this population is not activated upon energy deficit. Activating the LH Vgat population elicits consummatory behavior that is not specific to food but also directed toward a wide range of objects, including alcohol, nonnutritive sweeteners, water, and even a wooden stick [70][71][72] , which may not effectively resolve nutrient deficits. Instead, this population is crucial for non-homeostatic appetite driven by environmental cues 69 .…”

Section: Brain Circuits For Non-homeostatic Appetitementioning

confidence: 99%

Brain circuits for promoting homeostatic and non-homeostatic appetites

Ahn

Kim

2022

Exp Mol Med

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As the principal means of acquiring nutrients, feeding behavior is indispensable to the survival and well-being of animals. In response to energy or nutrient deficits, animals seek and consume food to maintain energy homeostasis. On the other hand, even when animals are calorically replete, non-homeostatic factors, such as the sight, smell, and taste of palatable food, or environmental cues that predict food, can stimulate feeding behavior. These homeostatic and non-homeostatic factors have traditionally been investigated separately, but a growing body of literature highlights that these factors work synergistically to promote feeding behavior. Furthermore, recent breakthroughs in cell type-specific and circuit-specific labeling, recording, and manipulation techniques have markedly accelerated the discovery of well-defined neural populations underlying homeostatic and non-homeostatic appetite control, as well as overlapping circuits that contribute to both types of appetite. This review aims to provide an update on our understanding of the neural circuit mechanisms for promoting homeostatic and non-homeostatic appetites, focusing on the function of recently identified, genetically defined cell types.

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A forebrain neural substrate for behavioral thermoregulation

Cited by 27 publications

References 86 publications

Lateral Septum Somatostatin Neurons are Activated by Diverse Stressors

Lateral Septum Somatostatin Neurons are Activated by Diverse Stressors

Modulation of the thermosensory system by oxytocin

Brain circuits for promoting homeostatic and non-homeostatic appetites

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