A fourth ventricular ganglioneurocytoma representing with cerebellar epilepsy: A case report and review of the literature

Dağçınar, Adnan; Kaya, Ahmet Hilmi; Taşdemir, Haydar Ali; Kuruoğlu, Enis; Sabancilar, Zafer; Sav, Aydın

doi:10.1016/j.ejpn.2007.02.005

Cited by 21 publications

(17 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These lesions produce paroxysmal and stereotyped attacks of hemifacial spasm and eye blinking associated with autonomic signs such as tachypnoea 2–9 . The onset of attacks usually occurs in the first days of life in otherwise healthy infants 3,5–7,9–17 . Intralesional electrical recordings and functional imaging studies have documented respectively, a hypersynchronous discharge and a hypermetabolism within the lesion and the brainstem nuclei, 3,5–7,9 which is congruent with the peculiar semiology of the paroxysmal attacks.…”

Section: Literature Review Of Published Reports Of Individuals With mentioning

confidence: 74%

Neonatal hemifacial spasm and fourth ventricle mass

Specchio

Trivisano

Bernardi

et al. 2012

Develop Med Child Neuro

View full text Add to dashboard Cite

Congential hemifacial spasm is a rare condition that is characterized by the occurrence of paroxysmal hemifacial contractions in neonates. We review the clinical, neurophysiological, neuroimaging, and histopathological findings, as well as the differential diagnosis, therapeutic approach, and outcome of all the described cases. Moreover, we report two new cases including the ictal video-electroencephalography recordings. Hemifacial spasm starts early in life, and is characterized by unilateral, involuntary, irregular tonic or clonic contractions of muscles innervated by the seventh cranial nerve. Hemifacial spasm is associated with eyelid blinking, and sometimes with breathing irregularities, hyperventilation, and ⁄ or other neurological manifestations (dystonic movements, nystagmus). Interictal and ictal video-electroencephalography did not reveal epileptiform abnormalities. In all cases, brain magnetic resonance imaging showed a mass involving the cerebellar peduncle, the cerebellar hemisphere, or the floor of the fourth ventricle. The semiology of the paroxysmal attacks is probably due to the activation of cranial nerve nuclei through intralesional hypersynchronous discharges, as shown by the intraoperative recordings and functional brain imaging described in the literature. We point out the importance of identifying such seizures in order to make an early diagnosis of the underlying cerebral lesion.

show abstract

Section: Literature Review Of Published Reports Of Individuals With mentioning

confidence: 74%

Neonatal hemifacial spasm and fourth ventricle mass

Specchio

Trivisano

Bernardi

et al. 2012

Develop Med Child Neuro

View full text Add to dashboard Cite

show abstract

“…Furthermore, gangliogliomas are among the most common epileptogenic lesions in epilepsy centers [21], harboring a major propensity for spontaneous electrical discharges which probably explains the association of this lesion to this unique syndrome [22]. Not unexpectedly, histological studies of cerebellar or fourth ventricle lesions presenting with subcortical epilepsy were classified as ganglioglioma [2,4,9,10,12,[23][24][25][26][27], hamartoma [8,13,14,28], gangliomatous hamartoma [29], ganglioneurocytoma [30][31][32] or low-grade dense fibrillary astrocytoma [3,15]. Although many of these lesions may carry a developmental origin and actually represent a continuum with FCD, some are not intrinsically epileptogenic [33].…”

Section: Discussionmentioning

confidence: 95%

Dysplastic Cerebellar Epilepsy: Complete Seizure Control Following Resection of a Ganglioglioma

et al. 2015

View full text Add to dashboard Cite

Subcortical epilepsy has been a controversial issue, partially settled by evidence showing seizure generation in hypothalamic hamartomas and also by reports of seizures caused by cerebellar lesions. We report 4-year-old girl with right hemifacial seizures and autonomic phenomena, in whom MRI showed an irregular mass in the right cerebellar peduncle. Despite several unremarkable video-EEG recordings, seizure origin in the lesion was hypothesized. Complete resection was feasible, histopathology showed a ganglioglioma, and she has been seizure free for 3 years. A fine line separates these developmental tumors from focal cortical dysplasia, and the homogeneous presentation of this entity led us to propose the terminology dysplastic cerebellar epilepsy.

show abstract

“…In order for this to occur, aberrant cerebello-pontine connections are required as normal cerebellar output is rubro-cortical or thalamo-cortical. Interestingly, there is only one other report of hemifacial seizures contralateral to a cerebellar lesion (Dagcinar et al, 2007), all others describe ictal semiology ipsilateral to the lesion which may be due to ephaptic propagation of ictal activity.…”

Section: Discussionmentioning

confidence: 99%

Tracking the source of cerebellar epilepsy: Hemifacial seizures associated with cerebellar cortical dysplasia

Lascano¹,

Lemkaddem²,

Granziera³

et al. 2013

Epilepsy Research

View full text Add to dashboard Cite

Summary Traditionally, subcortical structures such as the cerebellum are supposed to exert a modulatory effect on epileptic seizures, rather than being the primary seizure generator. We report a 14-month old girl presenting, since birth, with seizures symptomatic of a right cerebellar dysplasia, manifested as paroxystic contralateral hemifacial spasm and ipsilateral facial weakness. Multimodal imaging was used to investigate both anatomical landmarks related to the cerebellar lesion and mechanisms underlying seizure generation. Electric source imaging (ESI) supported the hypothesis of a right cerebellar epileptogenic generator in concordance with nuclear imaging findings; subsequently validated by intra-operative intralesional recordings. Diffusion spectrum imaging-related tractography (DSI) showed severe cerebellar structural abnormalities confirmed by histological examination. We suggest that hemispheric cerebellar lesions in cases like this are likely to cause epilepsy via an effect on the facial nuclei through ipsilateral and contralateral aberrant connections.

show abstract

A fourth ventricular ganglioneurocytoma representing with cerebellar epilepsy: A case report and review of the literature

Cited by 21 publications

References 10 publications

Neonatal hemifacial spasm and fourth ventricle mass

Neonatal hemifacial spasm and fourth ventricle mass

Dysplastic Cerebellar Epilepsy: Complete Seizure Control Following Resection of a Ganglioglioma

Tracking the source of cerebellar epilepsy: Hemifacial seizures associated with cerebellar cortical dysplasia

Contact Info

Product

Resources

About