A freeze-dried (lyophilized) amniotic membrane transplantation with mitomycin C and trabeculectomy for pediatric glaucoma

Mahdy, Reda A.; Nada, Waled M; Almasalamy, Salah M; Anany, Hesham A; Almasary, Ayman M

doi:10.3109/15569521003775005

Cited by 15 publications

(10 citation statements)

References 16 publications

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“…Heterogeneity appeared in some of the outcomes. This systematic review included all ages with glaucoma, of which Mahdy et al [ 23 ] assessed the children with glaucoma. After excluding primary pediatric glaucoma, the analysis showed similar results as previous.…”

Section: Resultsmentioning

confidence: 99%

Effectiveness and Safety of Trabeculectomy along with Amniotic Membrane Transplantation on Glaucoma: A Systematic Review

Shen

Cai

et al. 2020

Journal of Ophthalmology

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Purpose. To determine the effectiveness and safety of trabeculectomy along with amniotic membrane transplantation (AMT) for glaucoma. Methods. This systematic review was performed using RevMan 5.3. We searched PubMed, EMBASE, and the Cochrane Library and included studies published until September 2019. The treatment group included patients with AMT and trabeculectomy (group A), and the control group had only trabeculectomy (group B). We only included randomized controlled trials. The outcomes were intraocular pressure (IOP), complete success rate, number of antiglaucoma medications, and complications. Results. Five studies, including 174 eyes (87 eyes in the AMT group and 87 eyes in the control group), were eligible in this review. The parameters had no significant difference in heterogeneity between the AMT and control groups preoperatively. In the AMT group, the mean IOP was significantly lower at 3 and 12 months after operation (P < 0.0001 and P = 0.02, respectively), while the number of complete successes in the AMT group was significantly higher at 6 and 12 months (P = 0.02 and P = 0.003, respectively) compared with the control group. Complications, including a flat anterior chamber and hyphema, appeared to be decreased in the AMT group compared to the control group (P = 0.02 and P = 0.02, respectively). No differences were observed in the number of antiglaucoma medications, hypotony, encapsulated bleb, or choroidal detachment. Conclusion. Compared with only trabeculectomy, it is more efficient and safer to add AMT to trabeculectomy during glaucoma filtering surgery.

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Section: Resultsmentioning

confidence: 99%

Effectiveness and Safety of Trabeculectomy along with Amniotic Membrane Transplantation on Glaucoma: A Systematic Review

Shen

Cai

et al. 2020

Journal of Ophthalmology

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“…[2][3][4][5] Based on these dual properties, AMT has seen increased use as a means to assist the repair of leaking blebs [6][7][8] as well as to maintain filtering blebs after surgical bleb revision [9][10][11] and in additional trabeculectomy for eyes with refractory glaucoma. [12][13][14][15][16][17][18] Overall, AMT has been reported to increase the success rate of halting bleb leaks and of IOP control after trabeculectomy. However, many of these earlier studies were small case series with short-term follow up, in which IOP control was the only outcome measure evaluated.…”

Section: Introductionmentioning

confidence: 99%

Filtering Bleb Structure Associated with Long-Term Intraocular Pressure Control after Amniotic Membrane-Assisted Trabeculectomy

Nakamura

Naka

Tatsumi

et al. 2012

Current Eye Research

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“…In the present study, the structure of the FD-AM (which has been reported to be clinically useful in several medical fields [40][41][42][43] ) was much more fragile than that of the HD-AM, because the FD-AM had rich powder for the rupture of collagen bundles in connective tissues. The photograph of HD-AM stained with hematoxylin/eosin shows morphology similar to that of fAM.…”

Section: Discussionmentioning

confidence: 90%

Hyperdry human amniotic membrane is useful material for tissue engineering: Physical, morphological properties, and safety as the new biological material

Okabe

Kitagawa

Yoshida

et al. 2013

J Biomedical Materials Res

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Human amniotic membrane (AM) has been used widely as graft biomaterial for a variety of clinical applications. But, there are some persistent problems related to the preparation, storage, and sterilization. To resolve these problems, we developed hyperdry AM (HD-AM) using far-infrared rays, depression of air, and microwaves and then sterilized by γ-ray irradiation. To elucidate the benefit of HD-AM as biological materials, compare with the physical and histological properties of HD-AM with a freeze-dried AM (FD-AM) as typical freeze-dried methods, evaluate the safety of HD-AM in vivo experiment used nude mice, and demonstrate the feasibility of HD-AM transplant in pterygium. The water permeability and the sieving coefficient of HD-AM were significantly lower than that of FD-AM. HD-AM has kept the morphological structure of epithelium and connective tissues. At 18 months after transplanted, single and multilayers of HD-AM in the intraperitoneal cavity was degraded without any infiltrated cells. For clinical treatment, recurrence of pterygium and regrowth of the subconjunctival fibrosis were not observed during the 6-month follow-up periods after the surgery. It was proposed that HD-AM was a safe and effective new biological material for clinical use including treatment for recurrent pterygium.

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A freeze-dried (lyophilized) amniotic membrane transplantation with mitomycin C and trabeculectomy for pediatric glaucoma

Cited by 15 publications

References 16 publications

Effectiveness and Safety of Trabeculectomy along with Amniotic Membrane Transplantation on Glaucoma: A Systematic Review

Effectiveness and Safety of Trabeculectomy along with Amniotic Membrane Transplantation on Glaucoma: A Systematic Review

Filtering Bleb Structure Associated with Long-Term Intraocular Pressure Control after Amniotic Membrane-Assisted Trabeculectomy

Hyperdry human amniotic membrane is useful material for tissue engineering: Physical, morphological properties, and safety as the new biological material

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