2017
DOI: 10.1016/j.ijbiomac.2017.07.031
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A fucoidan fraction purified from Chnoospora minima; a potential inhibitor of LPS-induced inflammatory responses

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Cited by 130 publications
(105 citation statements)
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“…The results obtained in the study well aligns with an earlier report on polysaccharide extracts from Hizikia fusiforme [39]. Furthermore, fucoidan purified from brown algae has incorporated zebrafish studies as an in vivo model [12,40].…”
Section: Discussionsupporting
confidence: 89%
“…The results obtained in the study well aligns with an earlier report on polysaccharide extracts from Hizikia fusiforme [39]. Furthermore, fucoidan purified from brown algae has incorporated zebrafish studies as an in vivo model [12,40].…”
Section: Discussionsupporting
confidence: 89%
“…Approximate molecular weight distribution, homogeneity, and separation efficiency of the polysaccharide fractions were analyzed by an agarose gel electrophoresis method [3]. Briefly, markers and samples (1 mg mL −1 ) were electrophoresed in 1% agarose gels in Tris-Borate-EDTA running buffer (pH 8.3) at 100 V for 20 min.…”
Section: Analysis Of Molecular Weight (Mw) Distributionmentioning
confidence: 99%
“…High molecular weight fucoidans closely resemble the structure of heparin and are effective anticoagulants [2]. Nevertheless, low molecular weight fucoidans are reported to possess antioxidant, anti-inflammatory, anticancer and anti-microbial activities [3,4]. Fucoidan mainly contains α-1,3 and α-1,4-linked fucose units with sulfate ester substituents at the 2, 3 and/or 4 positions.…”
Section: Introductionmentioning
confidence: 99%
“…Over the last few decades, fucoidans purified from different species of brown alga have been extensively studied because of their broad spectrum of desirable biological activities, including anticoagulant, antithrombotic, antitumor, anti-inflammatory, and immunomodulatory effects [30]. In a recent in vitro study of RAW 264.7 macrophages, fucoidans purified from the marine brown alga Chnoospora minima were found to inhibit (i) the lipopolysaccharide (LPS)-induced production of nitrous oxide and PGE 2 via the downregulation of inducible nitric oxide synthase (iNOS) and COX-2 expression, and (ii) the production of TNF-α, IL1-β, and IL-6 [31]. Furthermore, sulfated polysaccharides extracted from other brown seaweeds (Sargassum hemiphyllum and Sargassum horneri) were shown to reduce pro-inflammatory cytokine production (IL-1β, IL-6 and TNF-α), NO production, and the expression of IL-1β, iNOS, and COX-2 and NF-κB (p65) in LPS-stimulated RAW 246.7 macrophages [32,33].…”
Section: Discussionmentioning
confidence: 99%