A fully integrated 8-channel closed-loop neural-prosthetic SoC for real-time epileptic seizure control

Chen, Wei-Ming; Chiueh, Herming; Chen, Tsan-Jieh; Ho, Chia-Lun; Jeng, Chi; Chang, Shun-Ting; Ker, Ming‐Dou; Lin, Chun‐Yu; Huang, Ya‐Chun; Chou, Chih‐Ju; Fan, Tsun-Yuan; Cheng, Mu-Huo; Liang, Sheng-Fu; Chien, Tzu-Chieh; Wu, None Sih-Yen; Wang, Yulin; Shaw, Fu-Zen; Huang, Yu‐Chun; Yang, Chia-Hsiang; Chiou, Jin-Chern; Chang, Chih-Wei; Chou, Lei-Chun; Wu, Chung‐Yu

doi:10.1109/isscc.2013.6487737

Cited by 6 publications

(4 citation statements)

References 5 publications

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“…Several stimulation artifact cancelation techniques have been reported previously. The blanking technique and digital signal processing (Erez et al, 2010) have been used to cancel the artifact (Olsson et al, 2005;Venkatraman et al, 2009;Kent and Grill, 2011;Myers et al, 2011;Zoladz et al, 2012;Wei-Ming et al, 2013;Yi et al, 2013;Bozorgzadeh et al, 2014;Elyahoodayan et al, 2019). In the blanking technique, the RFE is switched off or disabled (input is shorted to ground) during the stimulation period and turned on after the stimulation is completed to continue the recording.…”

Section: Key Issues In Neural Recording and Stimulation Circuits Stimulation Induced Artifact In The Closed-loop Systemmentioning

confidence: 99%

Advances in Neural Recording and Stimulation Integrated Circuits

Liu

Mao

et al. 2021

Front. Neurosci.

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In the past few decades, driven by the increasing demands in the biomedical field aiming to cure neurological diseases and improve the quality of daily lives of the patients, researchers began to take advantage of the semiconductor technology to develop miniaturized and power-efficient chips for implantable applications. The emergence of the integrated circuits for neural prosthesis improves the treatment process of epilepsy, hearing loss, retinal damage, and other neurological diseases, which brings benefits to many patients. However, considering the safety and accuracy in the neural prosthesis process, there are many research directions. In the process of chip design, designers need to carefully analyze various parameters, and investigate different design techniques. This article presents the advances in neural recording and stimulation integrated circuits, including (1) a brief introduction of the basics of neural prosthesis circuits and the repair process in the bionic neural link, (2) a systematic introduction of the basic architecture and the latest technology of neural recording and stimulation integrated circuits, (3) a summary of the key issues of neural recording and stimulation integrated circuits, and (4) a discussion about the considerations of neural recording and stimulation circuit architecture selection and a discussion of future trends. The overview would help the designers to understand the latest performances in many aspects and to meet the design requirements better.

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Section: Key Issues In Neural Recording and Stimulation Circuits Stimulation Induced Artifact In The Closed-loop Systemmentioning

confidence: 99%

Advances in Neural Recording and Stimulation Integrated Circuits

Liu

Mao

et al. 2021

Front. Neurosci.

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“…Up-conversion transmitters are transmitters in any frequency band, which utilize a mixer topology to up-convert the frequency content of the base band data signal. This technique is rarely used [104][105][106] because of its many drawbacks, albeit it has some advantage as well. The device needs two antennas, of which one is used for powering and one for data communication (In principle a single multimodal antenna could be used).…”

Section: B Remotely Powered Systemsmentioning

confidence: 99%

Feasibility of Energy-Autonomous Wireless Microsensors for Biomedical Applications: Powering and Communication

Goodarzy¹,

Skafidas²,

Gambini³

2015

IEEE Rev. Biomed. Eng.

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In this review, biomedical-related wireless miniature devices such as implantable medical devices, neural prostheses, embedded neural systems, and body area network systems are investigated and categorized. The two main subsystems of such designs, the RF subsystem and the energy source subsystem, are studied in detail. Different application classes are considered separately, focusing on their specific data rate and size characteristics. Also, the energy consumption of state-of-the-art communication practices is compared to the energy that can be generated by current energy scavenging devices, highlighting gaps and opportunities. The RF subsystem is classified, and the suitable architecture for each category of applications is highlighted. Finally, a new figure of merit suitable for wireless biomedical applications is introduced to measure the performance of these devices and assist the designer in selecting the proper system for the required application. This figure of merit can effectively fill the gap of a much required method for comparing different techniques in simulation stage before a final design is chosen for implementation.

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“…Functionally, neural stimulation is used to activate the prosthesis and wake up the sensory function [6], while neural recording can sense nerve signals or complete the evaluation of stimulation effect [7][8][9]. Combining neural stimulator and neural recorder, the closed-loop controlled simultaneous neural recording and stimulation system is formed to recover the basic functions of the injured individuals [10][11][12][13][14][15][16], such as the system for epileptic seizure detection and suppression [17,18].…”

Section: Introductionmentioning

confidence: 99%

A Neural Recording and Stimulation Chip with Artifact Suppression for Biomedical Devices

Liu

Chen

et al. 2021

Journal of Healthcare Engineering

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This paper presents chip implementation of the integrated neural recording and stimulation system with stimulation-induced artifact suppression. The implemented chip consists of low-power neural recording circuits, stimulation circuits, and action potential detection circuits. These circuits constitute a closed-loop simultaneous neural recording and stimulation system for biomedical devices, and a proposed artifact suppression technique is used in the system. Moreover, this paper also presents the measurement and experiment results of the implemented 4-to-4 channel neural recording and stimulation chip with 0.18 µm CMOS technology. The function and efficacy of simultaneous neural recording and stimulation is validated in both in vivo and animal experiments.

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A fully integrated 8-channel closed-loop neural-prosthetic SoC for real-time epileptic seizure control

Cited by 6 publications

References 5 publications

Advances in Neural Recording and Stimulation Integrated Circuits

Advances in Neural Recording and Stimulation Integrated Circuits

Feasibility of Energy-Autonomous Wireless Microsensors for Biomedical Applications: Powering and Communication

A Neural Recording and Stimulation Chip with Artifact Suppression for Biomedical Devices

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