A Fully Integrated Paper-Microfluidic Electrochemical Device for Simultaneous Analysis of Physiologic Blood Ions

Jin, Joon-Hyung; Kim, Joon Hyub; Lee, Sang Ki; Choi, Samjin; Park, Chan Won; Min, Nam Ki

doi:10.3390/s18010104

Cited by 25 publications

(20 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, printed carbon electrodes have been reported (Shitanda et al, 2018) for reducing the sensor cost. Although the majority of probe and chip devices are currently made from glass, silicon, and plastic materials, paper devices (Yang et al, 2017; Akyazi et al, 2018; Jin et al, 2018) are also widely used for low-cost assays. In the future, paper-based devices are expected to be more commonly used for on-chip cell analysis.…”

Section: Conclusion and Prospectsmentioning

confidence: 99%

Electric and Electrochemical Microfluidic Devices for Cell Analysis

et al. 2019

View full text Add to dashboard Cite

Microfluidic devices are widely used for cell analysis, including applications for single-cell analysis, healthcare, environmental monitoring, and organs-on-a-chip that mimic organs in microfluidics. Moreover, to enable high-throughput cell analysis, real-time monitoring, and non-invasive cell assays, electric and electrochemical systems have been incorporated into microfluidic devices. In this mini-review, we summarize recent advances in these systems, with applications from single cells to three-dimensional cultured cells and organs-on-a-chip. First, we summarize microfluidic devices combined with dielectrophoresis, electrophoresis, and electrowetting-on-a-dielectric for cell manipulation. Next, we review electric and electrochemical assays of cells to determine chemical section activity, and oxygen and glucose consumption activity, among other applications. In addition, we discuss recent devices designed for the electric and electrochemical collection of cell components from cells. Finally, we highlight the future directions of research in this field and their application prospects.

show abstract

Section: Conclusion and Prospectsmentioning

confidence: 99%

Electric and Electrochemical Microfluidic Devices for Cell Analysis

et al. 2019

View full text Add to dashboard Cite

show abstract

“…At present, the electrochemical potentiometric method [13][14][15][16][17][18] is the main method for electrolyte ions quantification. Other detection methods include the conductivity method [19,20], cyclic voltammetry (CV) [21][22][23][24][25][26], and coulometry [27,28].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Detection of Electrolytes Using a Solid-State Ion-Selective Electrode of Single-Piece Type Membrane

Chen

Wang

2021

Biosensors

View full text Add to dashboard Cite

This study aimed to develop simple electrochemical electrodes for the fast detection of chloride, sodium and potassium ions in human serum. A flat thin-film gold electrode was used as the detection electrode for chloride ions; a single-piece type membrane based solid-state ion-selective electrode (ISE), which was formed by covering a flat thin-film gold electrode with a mixture of 7,7,8,8-tetracyanoquinodimethane (TCNQ) and ion-selective membrane (ISM), was developed for sodium and potassium ions detection. Through cyclic voltammetry (CV) and square-wave voltammetry (SWV), the detection data can be obtained within two minutes. The linear detection ranges in the standard samples of chloride, sodium, and potassium ions were 25–200 mM, 50–200 mM, and 2–10 mM, with the average relative standard deviation (RSD) of 0.79%, 1.65%, and 0.47% and the average recovery rates of 101%, 100% and 96%, respectively. Interference experiments with Na+, K+, Cl−, Ca2+, and Mg2+ ions demonstrated that the proposed detection electrodes have good selectivity. Moreover, the proposed detection electrodes have characteristics such as the ability to be prepared under relatively simple process conditions, excellent detection sensitivity, and low RSD, and the detection linear range is suitable for the Cl−, Na+ and K+ concentrations in human serum.

show abstract

“…aptamer, paper-based sensor, potentiometry, whole virus, zika Lisak, Qin, & Bobacka, 2017;Jin et al, 2018;Kawahara, Sahatiya, Badhulika, & Uno, 2018;Kofler, Nau, & List-Kratochvil, 2015;Lisak, Cui, & Bobacka, 2015;Nery & Kubota, Apr., 2016;Parrilla, Cánovas, & Andrade, 2017;Ping et al, 2013;Sjöberg et al, 2016) utilize gradients of ion distributions that generate open-circuit voltages (V oc ) that are measured to transduce analytes. Paperbased pathogen and virus sensors are also easy to incinerate.…”

Section: Introductionmentioning

confidence: 99%

“…Paper‐based potentiometric sensors are reported for detecting many ions and proteins (Cui, Lisak, Strzalkowska, & Bobacka, 2014; HuJun, Stein, & Bühlmann, 2016; Novell et al, 2014; Szucs & Gyurcsányi, 2012). Potentiometric paper‐based sensors (Määttänen, 2013), (Ding, He, Lisak, Qin, & Bobacka, 2017; Jin et al, 2018; Kawahara, Sahatiya, Badhulika, & Uno, 2018; Kofler, Nau, & List‐Kratochvil, 2015; Lisak, Cui, & Bobacka, 2015; Nery & Kubota, Apr., 2016; Parrilla, Cánovas, & Andrade, 2017; Ping et al, 2013; Sjöberg et al, 2016) utilize gradients of ion distributions that generate open‐circuit voltages (V oc ) that are measured to transduce analytes. Paper‐based pathogen and virus sensors are also easy to incinerate.…”

Section: Introductionmentioning

confidence: 99%

Whole virus detection using aptamers and paper‐based sensor potentiometry

Dolai

Tabib‐Azar

2020

Med Devices & Sens

View full text Add to dashboard Cite

Paper‐based sensors, microfluidic platforms, and electronics have attracted attention in the past couple of decades because they are flexible, can be recycled easily, environmentally friendly, and inexpensive. Here we report a paper‐based potentiometric sensor to detect the whole Zika virus with a minimum sensitivity of 0.26 nV/Zika and a minimum detectable signal (MDS) of 2.4x10 7 Zika. Our paper sensor works very similar to a P‐N junction where a junction is formed between two different regions with different electrochemical potentials on the paper. These two regions with slightly different ionic contents, ionic species and concentrations, produce a potential difference given by the Nernst equation. Our paper sensor consists of 2‐3 mm x 10 mm segments of paper with conducting silver paint contact patches on two ends. The paper is dipped in a buffer solution containing aptamers designed to bind to the capsid proteins on Zika. We then added the Zika (in its own buffer) to the region close to one of the silver‐paint contacts. The Zika virus (40 nm diameter with 43 kDa or 7.1x10 ‐20 gm weight) became immobilized in the paper’s pores and bonded with the resident aptamers creating a concentration gradient. Atomic force microscopy and Raman spectroscopy were carried out to verify that both the aptamer and Zika become immobilized in the paper. The potential measured between the two silver paint contacts reproducibly became more negative upon adding the Zika. We also showed that a Liquid Crystalline Display (LCD) powered by the sensor can be used to read the sensor output.

show abstract

A Fully Integrated Paper-Microfluidic Electrochemical Device for Simultaneous Analysis of Physiologic Blood Ions

Cited by 25 publications

References 17 publications

Electric and Electrochemical Microfluidic Devices for Cell Analysis

Electric and Electrochemical Microfluidic Devices for Cell Analysis

Electrochemical Detection of Electrolytes Using a Solid-State Ion-Selective Electrode of Single-Piece Type Membrane

Whole virus detection using aptamers and paper‐based sensor potentiometry

Contact Info

Product

Resources

About