A Fully Integrated RF-Powered Energy-Replenishing Current-Controlled Stimulator

Ha, Sohmyung; Kim, Chul; Park, Jiwoong; Cauwenberghs, Gert; Mercier, Patrick P.

doi:10.1109/tbcas.2018.2881800

Cited by 25 publications

(5 citation statements)

References 54 publications

(52 reference statements)

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“…For example, the integrated stimulator presented in Jiang et al (2021) is implemented 180 nm CMOS and consumes only 1 mW when generating 50 Hz, 50% duty cycle current pulses of 16 mA. The energy consumed by the output stage circuit can be reduced by dynamic compliance voltage techniques (Samiei and Hashemi, 2021) and energy recycling methods (Ha et al, 2019); 2) Physical Size: The power isolation scheme requires the substrate of the parallel stimulators to be separated. Using 0.6 µm CMOS technology, the stimulators have to be implemented in separate ASICs.…”

Section: Discussionmentioning

confidence: 99%

A Versatile Hermetically Sealed Microelectronic Implant for Peripheral Nerve Stimulation Applications

et al. 2021

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This article presents a versatile neurostimulation platform featuring a fully implantable multi-channel neural stimulator for chronic experimental studies with freely moving large animal models involving peripheral nerves. The implant is hermetically sealed in a ceramic enclosure and encapsulated in medical grade silicone rubber, and then underwent active tests at accelerated aging conditions at 100°C for 15 consecutive days. The stimulator microelectronics are implemented in a 0.6-μm CMOS technology, with a crosstalk reduction scheme to minimize cross-channel interference, and high-speed power and data telemetry for battery-less operation. A wearable transmitter equipped with a Bluetooth Low Energy radio link, and a custom graphical user interface provide real-time, remotely controlled stimulation. Three parallel stimulators provide independent stimulation on three channels, where each stimulator supports six stimulating sites and two return sites through multiplexing, hence the implant can facilitate stimulation at up to 36 different electrode pairs. The design of the electronics, method of hermetic packaging and electrical performance as well as in vitro testing with electrodes in saline are presented.

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Section: Discussionmentioning

confidence: 99%

A Versatile Hermetically Sealed Microelectronic Implant for Peripheral Nerve Stimulation Applications

et al. 2021

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“…However, the injected charge is likely to be unbalanced because impedance of the electrode-tissue interface varies (Vidal and Ghovanloo, 2010;Lee et al, 2014). Current-controlled stimulation (CCS) in Figure 5C uses current sources instead, and therefore, accurately manages the amount of current for charge balance (Ha et al, 2018). For a high impedance electrode-tissue interface, however, large supply voltage is essential for a sufficient voltage headroom of the current source and it results in high power consumption (Ghovanloo, 2006).…”

Section: Figure 5amentioning

confidence: 99%

Energy-Efficient Integrated Circuit Solutions Toward Miniaturized Closed-Loop Neural Interface Systems

et al. 2021

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Miniaturized implantable devices play a crucial role in neural interfaces by monitoring and modulating neural activities on the peripheral and central nervous systems. Research efforts toward a compact wireless closed-loop system stimulating the nerve automatically according to the user's condition have been maintained. These systems have several advantages over open-loop stimulation systems such as reduction in both power consumption and side effects of continuous stimulation. Furthermore, a compact and wireless device consuming low energy alleviates foreign body reactions and risk of frequent surgical operations. Unfortunately, however, the miniaturized closed-loop neural interface system induces several hardware design challenges such as neural activity recording with severe stimulation artifact, real-time stimulation artifact removal, and energy-efficient wireless power delivery. Here, we will review recent approaches toward the miniaturized closed-loop neural interface system with integrated circuit (IC) techniques.

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“…Excessive thermal power generation will not only cause nerve tissue damage, but also affect the working environment of the stimulator. A new type of adiabatic current-controlled stimulator architecture is adopted in Ha et al (2019). Under the condition of ensuring better power efficiency, a complete wireless power supply is realized.…”

Section: Advances In Neural Recording and Stimulation Integrated Circuits Neural Stimulationmentioning

confidence: 99%

Advances in Neural Recording and Stimulation Integrated Circuits

Liu

Mao

et al. 2021

Front. Neurosci.

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In the past few decades, driven by the increasing demands in the biomedical field aiming to cure neurological diseases and improve the quality of daily lives of the patients, researchers began to take advantage of the semiconductor technology to develop miniaturized and power-efficient chips for implantable applications. The emergence of the integrated circuits for neural prosthesis improves the treatment process of epilepsy, hearing loss, retinal damage, and other neurological diseases, which brings benefits to many patients. However, considering the safety and accuracy in the neural prosthesis process, there are many research directions. In the process of chip design, designers need to carefully analyze various parameters, and investigate different design techniques. This article presents the advances in neural recording and stimulation integrated circuits, including (1) a brief introduction of the basics of neural prosthesis circuits and the repair process in the bionic neural link, (2) a systematic introduction of the basic architecture and the latest technology of neural recording and stimulation integrated circuits, (3) a summary of the key issues of neural recording and stimulation integrated circuits, and (4) a discussion about the considerations of neural recording and stimulation circuit architecture selection and a discussion of future trends. The overview would help the designers to understand the latest performances in many aspects and to meet the design requirements better.

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A Fully Integrated RF-Powered Energy-Replenishing Current-Controlled Stimulator

Cited by 25 publications

References 54 publications

A Versatile Hermetically Sealed Microelectronic Implant for Peripheral Nerve Stimulation Applications

A Versatile Hermetically Sealed Microelectronic Implant for Peripheral Nerve Stimulation Applications

Energy-Efficient Integrated Circuit Solutions Toward Miniaturized Closed-Loop Neural Interface Systems

Advances in Neural Recording and Stimulation Integrated Circuits

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