A Functional Continuum of Regulatory Anxiety-Enhancing Peptides. The Search for Complexes Providing the Optimal Basis for Developing Inhibitory Therapeutic Agents

Koroleva, S. V.; Ашмарин, И. П.

doi:10.1007/s11055-005-0174-2

Cited by 6 publications

(3 citation statements)

References 44 publications

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“…This sets forth the functional continuum of regulatory peptides that participate in the transfer of information among the systems of the body (its organs, tissues, cell groups, and individual cells), thereby regulating their activity and integrating their performance into a unity. Thus, the regulatory-peptide system is involved in the regulation of virtually all physiological responses of the body, and maintains the homeostasis of all of its systems [3][4][5][6].…”

Section: Natural and Synthetic Regulatory Peptidesmentioning

confidence: 99%

A New Generation of Drugs: Synthetic Peptides Based on Natural Regulatory Peptides

Kolomin¹,

Шадрина²,

Slominsky³

et al. 2013

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Natural regulatory peptides are biologically active compounds that are produced by various cells and provide a link among the main regulatory systems of the body. The field of research into the biologic activity of endogenous regulatory peptides is extremely vast. These peptides affect the cardiovascular, immune, reproductive, endocrine, digestive, and other systems, alter energy metabolism, and are especially effective in the regulation of the central nervous system. Despite of the wide range of preventive and therapeutic effects of natural regulatory peptides and proteins, their application in clinical practice is difficult. This is primarily because of their extreme instability, as they are rapidly degraded by proteases of the gastrointestinal tract, blood, cerebrospinal fluid, and other biologic media. Compounds with higher stability (i.e., a considerably longer half-life compared with that of natural molecules) and the ability to provide a directional effect on the various body systems were obtained from modifications of endogenous regulatory peptides. Synthetic analogs of regulatory peptides, as a rule, contain only natural amino acids in their composition, and their biodegradation does not lead to the formation of toxic products; thus, they have fewer side effects. This review focuses on the consideration of two synthetic regulatory peptides, Semax and Selank, which were the bases for the creation of new drugs that are used effectively in the treatment of various diseases of the nervous system. The synthetic analog of an adrenocorticotropic hormone 4-10 fragment (ACTH 4-10) Semax is a powerful neuroprotective agent that is particularly effective as a therapy for stroke. Selank was synthesized on the basis of the natural immunomodulator tuftsin. Selank is a powerful anxiolytic that is used as a therapy for generalized anxiety disorder and neurasthenia without sedative and muscle-relaxant effects. This review presents the results of research aimed at studying the influence of these peptides on the transcriptome of brain cells. The problems of drugs developed based on the clinical activities of Semax and Selank are discussed separately.

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Section: Natural and Synthetic Regulatory Peptidesmentioning

confidence: 99%

A New Generation of Drugs: Synthetic Peptides Based on Natural Regulatory Peptides

Kolomin¹,

Шадрина²,

Slominsky³

et al. 2013

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“…В нейропсихофармакологии нейропептиды рассматриваются как альтернатива лекарственным средствам с моноаминергическим действием. Пептидный континуум, предложенный И. П. Ашмарином, указывает на комплексность, эволюционную логичность и сбалансированность эффектов нейропептидов, что опосредовано их местом в системе межмедиаторных взаимодействий [1].…”

Section: Introductionunclassified

Pharmacological potential of ligands to receptors of RF-amide neuropeptide system

Yakovlev¹,

Венгерович

Никифоров³

et al. 2022

Pharmacy Formulas

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The system of neuropeptides has a significant impact on different functions of the central nervous system, acting as a launching ground for the development of new generation drugs that have a complex therapeutic effect in mood disorders, nociception, reproductive behavior with minimal side effects, which is confirmed by the data of a number of preclinical studies. The review considers a promising neuropeptide system of the RF-amide family, which can become the basis for the development of new drugs, complementing the therapeutic possibilities of physiologically active substances with a more selective effect on certain pathological processes. The main groups of neuropeptides of the RF-system were identified: neuropeptides FF, 26 RF-amides, kisspeptins, prolactin-releasing and gonadotropin-inhibiting peptides. For each of these groups descriptions of biological effects are presented, including antinoceptive action, influence on the regulation of energy homeostasis, influence on reproductive behavior, etc. A number of non-peptide ligands for RF-amide receptors developed and available for research have been identified.

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“…Академик И.П. Ашмарин в 80-90-е годы [4][5][6] сформулировал концепцию о функциональном континууме регуляторных пептидов и пептидном каскаде, которую продолжал развивать [7] и в последующие годы. Регуляторные пептиды -это универсальные эндогенные биорегуляторы клеточных функций в организме.…”

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Molecular mechanisms of brain peptide-containing drugs: cortexin

Gulyaeva

2018

Z. nevrol. psikhiatr. im. S.S. Korsakova

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ФГБУН «Институт высшей нервной деятельности и нейрофизиологии» РАН, Москва, Россия; ГБУЗ «Научно-практический психоневрологический центр им. З.П. Соловьева» Департамента здравоохранения Москвы, Москва, Россия В статье рассмотрены новые данные, касающиеся ключевых молекулярных механизмов, которые могут лежать в основе нейропротективных свойств многокомпонентных лекарственных органоспецифичных препаратов, представляющих собой выделенные из мозга животных пептидные гидролизаты. Такие препараты, в том числе кортексин, в настоящее время достаточно широко используются для лечения церебральных патологий. Показано, что потенциальные молекулярные механизмы нейропротективных эффектов кортексина разнообразны и касаются ключевых процессов, лежаших в основе нейропластичности: трансдукции сигнала, энергетического метаболизма, протеолитической модификации белков, структуры клеток мозга, а также процессов нейровоспаления. В основе плейотропности механизмов действия кортексина лежит состав препарата, содержащего множество различных нейропептидов. Тканеспецифичность выявленных молекулярных механизмов в значительной степени определяет эффективность препарата при церебральных патологиях.

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A Functional Continuum of Regulatory Anxiety-Enhancing Peptides. The Search for Complexes Providing the Optimal Basis for Developing Inhibitory Therapeutic Agents

Cited by 6 publications

References 44 publications

A New Generation of Drugs: Synthetic Peptides Based on Natural Regulatory Peptides

A New Generation of Drugs: Synthetic Peptides Based on Natural Regulatory Peptides

Pharmacological potential of ligands to receptors of RF-amide neuropeptide system

Molecular mechanisms of brain peptide-containing drugs: cortexin

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