A functional interaction between Hippo‐YAP signalling and SREBPs mediates hepatic steatosis in diabetic mice

Shu, Zhiping; Gao, Yuan; Zhang, Guopeng; Zhou, Yu; Cao, Jiang; Wan, Dongyi; Xian, Zhu; Xiong, Wenqian

doi:10.1111/jcmm.14262

Cited by 48 publications

(44 citation statements)

References 52 publications

(80 reference statements)

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“…YAP/TAZ has been reported to interact with mature SREBPs within the nucleus leading to enhanced transcriptional activities and increased expression of downstream targets, such as HMGCR and the fatty acids synthase (FAS). Activation of the Hippo signaling pathway was found to reduce hepatic steatosis in diabetic mice 126 . YAP also appears to participate in regulating FAO, and thus in helping cancer cells undergoing metastasis via the tumor‐draining lymph nodes (LNs) to survive within the LN microenvironment 127 .…”

Section: Molecular Mechanisms Of Lipid Metabolic Reprogrammingmentioning

confidence: 99%

Lipid metabolism in cancer progression and therapeutic strategies

Zou

Shen

et al. 2020

MedComm

181

113

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Dysregulated lipid metabolism represents an important metabolic alteration in cancer. Fatty acids, cholesterol, and phospholipid are the three most prevalent lipids that act as energy producers, signaling molecules, and source material for the biogenesis of cell membranes. The enhanced synthesis, storage, and uptake of lipids contribute to cancer progression. The rewiring of lipid metabolism in cancer has been linked to the activation of oncogenic signaling pathways and cross talk with the tumor microenvironment. The resulting activity favors the survival and proliferation of tumor cells in the harsh conditions within the tumor. Lipid metabolism also plays a vital role in tumor immunogenicity via effects on the function of the noncancer cells within the tumor microenvironment, especially immune‐associated cells. Targeting altered lipid metabolism pathways has shown potential as a promising anticancer therapy. Here, we review recent evidence implicating the contribution of lipid metabolic reprogramming in cancer to cancer progression, and discuss the molecular mechanisms underlying lipid metabolism rewiring in cancer, and potential therapeutic strategies directed toward lipid metabolism in cancer. This review sheds new light to fully understanding of the role of lipid metabolic reprogramming in the context of cancer and provides valuable clues on therapeutic strategies targeting lipid metabolism in cancer.

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Section: Molecular Mechanisms Of Lipid Metabolic Reprogrammingmentioning

confidence: 99%

Lipid metabolism in cancer progression and therapeutic strategies

Zou

Shen

et al. 2020

MedComm

181

113

View full text Add to dashboard Cite

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“…Previous studies have shown that YAP/TAZ promotes fatty acid and triglyceride synthesis by upregulating FAS ( 11 , 96 ), ACL ( 11 ), ACC ( 11 , 96 ), and SCD-1 ( 11 , 96 ) through upregulated SREBP1. In addition, YAP/TAZ reportedly upregulated 30-hydroxymethyl glutaryl coenzyme A reductase ( 96 ) in cultured C57BL/6 mouse hepatocytes, by upregulating SREBP2, which in turn increased cellular cholesterol synthesis. In vitro HCC experiments revealed that YAP/TAZ promoted cancer cell proliferation by increasing lipid formation ( 11 ).…”

Section: Ecm Stiffness and Lipid Metabolismmentioning

confidence: 99%

Extracellular Matrix Stiffness: New Areas Affecting Cell Metabolism

Tian

Pei

et al. 2021

Front. Oncol.

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In recent years, in-depth studies have shown that extracellular matrix stiffness plays an important role in cell growth, proliferation, migration, immunity, malignant transformation, and apoptosis. Most of these processes entail metabolic reprogramming of cells. However, the exact mechanism through which extracellular matrix stiffness leads to metabolic reprogramming remains unclear. Insights regarding the relationship between extracellular matrix stiffness and metabolism could help unravel novel therapeutic targets and guide development of clinical approaches against a myriad of diseases. This review provides an overview of different pathways of extracellular matrix stiffness involved in regulating glucose, lipid and amino acid metabolism.

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“…The sterol regulatory element-binding proteins (SREBPs) are transcription factors that control the expression of enzymes involved in fatty acid and cholesterol biosynthesis (146). It has been reported that YAP interacts with the nuclear forms of SREBP1 and SREBP2 and enhances their transcriptional activities toward fatty acids synthase (FAS) and 30-hydroxylmethyl glutaryl coenzyme A reductase (HMGCR) (147). Also, the study has shown that the activation of LATS1 or inhibition of YAP reduced hepatic steatosis and hyperlipidaemia in diet-induced diabetic mice (147).…”

Section: The Role Of Yap/taz In Lipid Metabolismmentioning

confidence: 99%

A Potential Role of YAP/TAZ in the Interplay Between Metastasis and Metabolic Alterations

Yamaguchi

Taouk

2020

Front. Oncol.

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Yes-Associated Protein (YAP) and Transcriptional Co-activator with PDZ-binding Motif (TAZ) are the downstream effectors of the Hippo signaling pathway that play a crucial role in various aspects of cancer progression including metastasis. Metastasis is the multistep process of disseminating cancer cells in a body and responsible for the majority of cancer-related death. Emerging evidence has shown that cancer cells reprogram their metabolism to gain proliferation, invasion, migration, and anti-apoptotic abilities and adapt to various environment during metastasis. Moreover, it has increasingly been recognized that YAP/TAZ regulates cellular metabolism that is associated with the phenotypic changes, and recent studies suggest that the YAP/TAZ-mediated metabolic alterations contribute to metastasis. In this review, we will introduce the latest knowledge of YAP/TAZ regulation and function in cancer metastasis and metabolism, and discuss possible links between the YAP/TAZ-mediated metabolic reprogramming and metastasis.

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A functional interaction between Hippo‐YAP signalling and SREBPs mediates hepatic steatosis in diabetic mice

Cited by 48 publications

References 52 publications

Lipid metabolism in cancer progression and therapeutic strategies

Lipid metabolism in cancer progression and therapeutic strategies

Extracellular Matrix Stiffness: New Areas Affecting Cell Metabolism

A Potential Role of YAP/TAZ in the Interplay Between Metastasis and Metabolic Alterations

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