A functional MRI study of a paced motor activation task to evaluate frontal-subcortical circuit function in bipolar depression

Marchand, William R.; Lee, James N.; Thatcher, Grant William; Jensen, Cody; Stewart, Dawn; Dilda, Valentina; Thatcher, John W.; Creem-Regehr, Sarah H.

doi:10.1016/j.pscychresns.2007.03.003

Cited by 63 publications

(31 citation statements)

References 39 publications

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“…Therefore, these abnormalities could either be interpreted as being trait related or mood state nonspecific, that is, these abnormalities are related to an abnormal mood state regardless of valence. A number of previous studies, which have examined activation and connectivity abnormalities concurrently in mania and depression, have also uncovered many similar findings in both BPM and BPD (Anand et al, 2009;Chen et al, 2006;Hulvershorn et al, 2012;Hummer et al, 2013;Marchand et al, 2007a;Phillips and Swartz, 2014;Wessa et al, 2007). To definitely ascertain that these abnormalities are trait related, they need to be investigated in medication-free euthymic subjects in future studies.…”

Section: Discussionmentioning

confidence: 85%

Differential Resting-State Functional Connectivity of Striatal Subregions in Bipolar Depression and Hypomania

et al. 2016

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Bipolar disorder (BP) is characterized by periods of depression (BPD) and (hypo)mania (BPM), but the underlying state-related brain circuit abnormalities are not fully understood. Striatal functional activation and connectivity abnormalities have been noted in BP, but consistent findings have not been reported. To further elucidate striatal abnormalities in different BP states, this study investigated differences in resting-state functional connectivity of six striatal subregions in BPD, BPM, and healthy control (HC) subjects. Ninety medication-free subjects (30 BPD, 30 BPM, and 30 HC), closely matched for age and gender, were scanned using 3T functional magnetic resonance imaging (fMRI) acquired at resting state. Correlations of low-frequency blood oxygen level dependent signal fluctuations for six previously described striatal subregions were used to obtain connectivity maps of each subregion. Using a factorial design, main effects for differences between groups were obtained and post hoc pairwise group comparisons performed. BPD showed increased connectivity of the dorsal caudal putamen with somatosensory areas such as the insula and temporal gyrus. BPM group showed unique increased connectivity between left dorsal caudate and midbrain regions, as well as increased connectivity between ventral striatum inferior and thalamus. In addition, both BPD and BPM exhibited widespread functional connectivity abnormalities between striatal subregions and frontal cortices, limbic regions, and midbrain structures. In summary, BPD exhibited connectivity abnormalities of associative and somatosensory subregions of the putamen, while BPM exhibited connectivity abnormalities of associative and limbic caudate. Most other striatal subregion connectivity abnormalities were common to both groups and may be trait related.

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Section: Discussionmentioning

confidence: 85%

Differential Resting-State Functional Connectivity of Striatal Subregions in Bipolar Depression and Hypomania

et al. 2016

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“…Findings from these studies show reduced activity in remitted BD relative to healthy adults during these paradigms in left-sided regions, including OFC/VLPFC and MdPFC 149,150 and right-sided regions, including MdPFC 151 and dorsal ACG, but also increased activity in right DLPFC. 152 Other studies show reduced left OFC activity, 149 or no functional abnormalities in PFC, 153 in BD depression; and reduced left OFC activity during BD mania 149 relative to healthy volunteers. The majority of these studies show intact, although some show impaired, 154 task performance in BD adults.…”

Section: Adult Bipolar Disordermentioning

confidence: 98%

A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder

2008

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The ability to regulate emotions is an important part of adaptive functioning in society. Advances in cognitive and affective neuroscience and biological psychiatry have facilitated examination of neural systems that may be important for emotion regulation. In this critical review we first develop a neural model of emotion regulation that includes neural systems implicated in different voluntary and automatic emotion regulatory subprocesses. We then use this model as a theoretical framework to examine functional neural abnormalities in these neural systems that may predispose to the development of a major psychiatric disorder characterized by severe emotion dysregulation, bipolar disorder.

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“…One recent study [30] demonstrated decreased dorsal cingulate activity during a color-word Stroop task and increased striatal activity during a paced motor task in bipolar depressed individuals compared with controls. One study examining remitted patients with subsyndromal depression during an attentional task [31] found decreased VLPFC activity with depression severity correlating negatively with the magnitude of VLPFC decrease (ie, greater depression severity was associated with more normalized VLPFC activity).…”

Section: Bipolar Depressionmentioning

confidence: 99%

Neuroimaging in bipolar disorder: A critical review of current findings

Keener

Phillips²

2007

Curr Psychiatry Rep

102

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Bipolar I disorder (BPI) is among the top 10 most debilitating illnesses globally. In this critical review, we first review recent functional neuroimaging findings in two core domains of pathology in BPI: emotion processing and executive control. These abnormalities in core domains represent potential endophenotypes of the illness. We then show that an emerging number of studies have demonstrated that neuroimaging can help to identify endophenotypic markers whose identification would help to clarify diagnosis and discriminate the depression in BPI from that of unipolar depression and identify at-risk individuals who will subsequently develop the illness (to facilitate early intervention). We end by reviewing the new directions in neuroimaging in BPI, including studies of children with bipolar disorder, potential medication effects, and the use of newer neuroimaging techniques to help us achieve the previously mentioned goals of improving BPI patients' mental well-being.

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A functional MRI study of a paced motor activation task to evaluate frontal-subcortical circuit function in bipolar depression

Cited by 63 publications

References 39 publications

Differential Resting-State Functional Connectivity of Striatal Subregions in Bipolar Depression and Hypomania

Differential Resting-State Functional Connectivity of Striatal Subregions in Bipolar Depression and Hypomania

A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder

Neuroimaging in bipolar disorder: A critical review of current findings

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