A Functional SNP of the Interleukin-18 Gene Is Associated with the Presence of Hepatocellular Carcinoma in Hepatitis B Virus-Infected Patients

Kim, Yong Seok; Cheong, Jae Youn; Cho, Sung Won; Lee, Kee Myung; Hwang, Jae Chul; Oh, Bermseok; Kimm, Kuchan; Lee, Jung A.; Park, Byung Lae; Cheong, Hyun Sub; Shin, Hyoung Doo; Kim, Jin Hong

doi:10.1007/s10620-009-0970-6

Cited by 33 publications

(29 citation statements)

References 25 publications

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“…A further two studies3839 were excluded because they included either patients with only liver cirrhosis or an aggregated patient population with HCC or liver cirrhosis. In the end, 8 studies1213141516171819 were included in the final meta-analysis based on our search strategy and inclusion criteria (Table 1). Of these 8 studies, all1213141516171819 evaluated the association between the -137 polymorphism and HCC risk (1,318 cases, 2,254 controls), while 7 studies12141516171819 evaluated the association between the -607 polymorphism and HCC risk (1,262 cases, 1,696 controls).…”

Section: Resultsmentioning

confidence: 99%

“…Of these 8 studies, all1213141516171819 evaluated the association between the -137 polymorphism and HCC risk (1,318 cases, 2,254 controls), while 7 studies12141516171819 evaluated the association between the -607 polymorphism and HCC risk (1,262 cases, 1,696 controls). The distribution of genotypes in controls was consistent with Hardy-Weinberg equilibrium (HWE, P > 0.05) in all but two studies1315. The overall quality of the included studies was adequate.…”

Section: Resultsmentioning

confidence: 99%

“…Indeed, numerous case-control studies1213141516171819 have investigated whether polymorphisms at position -137 (rs187238) and -607 (rs1946518) within the IL-18 promoter influence risk of HCC. Results have been inconclusive and contradictory, prompting us to perform the first comprehensive meta-analysis of all available evidence on these potential associations.…”

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confidence: 99%

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Genetic polymorphisms -137 (rs187238) and -607 (rs1946518) in the interleukin-18 promoter may not be associated with development of hepatocellular carcinoma

Zhu

Zhao

et al. 2016

Sci Rep

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This study meta-analyzed the literature on possible association of polymorphisms -137 (rs187238) and -607 (rs1946518) in the interleukin-18 (IL-18) promoter with risk of hepatocellular carcinoma (HCC). The analysis included 8 case-control studies on the -137 polymorphism (1,318 cases, 2,254 controls) and 7 case-control studies on the -607 polymorphism (1,262 cases, 1,696 controls). None of the five genetic models suggested a significant association between the -137 polymorphism and HCC risk: allelic model, OR 0.99, 95% CI 0.74–1.34, P = 0.97; recessive model, OR 0.98, 95% CI 0.65–1.46, P = 0.91; dominant model, OR 1.35, 95% CI 0.73–2.52, P = 0.34; homozygous model, OR 0.99, 95% CI 0.65–1.49, P = 0.95; heterozygous model, OR 0.99, 95% CI 0.66–1.48, P = 0.94. Similar results were obtained in subgroup analyses of Asian patients, Chinese patients, or patients with hepatitis B virus (HBV)-related HCC. Similar results were also obtained for the -607 polymorphism across the entire study population as well as in the three subgroups. The available evidence suggests no significant association of the -137 or -607 polymorphisms with risk of HCC in general or specifically of HBV-related HCC. These conclusions should be verified in large, well-designed studies.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Genetic polymorphisms -137 (rs187238) and -607 (rs1946518) in the interleukin-18 promoter may not be associated with development of hepatocellular carcinoma

Zhu

Zhao

et al. 2016

Sci Rep

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“…Recently, increased production of proinflammatory cytokines and chemokines, such as tumor necrosis factor-a (TNFa) (Park et al, 2010), interleukin-1b (IL-1b) (Okamoto et al, 2010), and interleukin-8 (IL-8) (Wei et al, 2007), interleukin-10 (IL-10) (Shin et al, 2003), interleukin-18 (IL-18) (Kim et al, 2009) have been reported to be associated with tumor and chronic inflammatory disease. These cytokines are produced by immune cells including various populations of lymphocytes, macrophages, and other cells.…”

Section: Introductionmentioning

confidence: 99%

The IL-8 Gene Polymorphisms and the Risk of the Hepatitis B Virus/Infected Patients

Qin

Deng²,

Liao³

et al. 2012

DNA and Cell Biology

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Interleukin-8 (IL-8) belongs to the superfamily of CXC chemokines, contributing to human cancer progression through potential mitogenic, angiogenic, and motogenic functions. We hypothesize that the functional polymorphism of IL-8 may influence the inflammatory process during pathological stage from hepatitis to hepatocellular carcinoma (HCC). Two polymorphisms in the IL-8 gene (-251A/T and +781C/T) were examined in 160 cases of chronic hepatitis B, 80 cases of hepatitis B virus (HBV)-related liver cirrhosis (LC), 150 cases of HBV-related HCC, and 150 healthy controls using polymerase chain reaction-restriction fragment length polymorphism method and DNA sequencing. In the LC group, the AA genotypes were associated with a significantly decreased risk of LC compared with the TT genotype (OR=0.14, 95% CI 0.02-0.87, p=0.035). The data also revealed that subjects with the A allele appeared to have lower susceptibility to LC than those with the T allele (OR=0.48, 95% CI 0.25-0.92, p=0.027). The +781C/T polymorphism of IL-8 was not found relevant to the liver diseases. This study indicated that the IL-8 gene -251 AA genotype might be a protect factor for LC.

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“…The different outcomes of HBV infection are associated with genetic factors such as allelic variants in the human genome that may affect the progression of viral hepatitis after infection (Thursz, 2001). In addition, many reports have also suggested associations between genetic polymorphisms and the risk of HBV infection and/or HCC occurrence Park et al, 2010;Kim et al, 2003;Shin et al, 2003;Kim et al, 2006;Park et al, 2006;Park et al, 2007;Shin et al, 2007;Chun et al, 2009;Kim et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Lack of association between FOS polymorphisms and clearance of HBV infection as well as HCC occurrence

et al. 2011

Self Cite

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Human v-Fos Finuel-Biskis-Jinkins (FBJ) murine osteosarcoma viral oncogene homolog (FOS) is located in 14q24.3. The FOS protein is a constituent of the activating protein-1 (AP-1) and its increased expression in the hepatocellular carcinoma (HCC) have been reported. In this study, the association of FOS polymorphisms with the HBV infection and HCC occurrence were evaluated in Korean patients. After re-sequencing in 24 unrelated healthy individuals, two common single nucleotide polymorphisms (SNPs) in regulatory regions that were selected based on linkage disequilibrium were genotyped in a total of 1,093 Korean subjects including 656 HBV chronic carriers, who were further stratified into chronic hepatitis/liver cirrhosis (CH/LC, n = 339) and HCC (n = 317) groups, and 437 spontaneously recovered (SR) controls. Logistic regression and Cox relative hazard analysis showed no significant association of regulatory polymorphisms and haplotypes in FOS with HBV clearance and HCC development (P > 0.05, respectively).

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A Functional SNP of the Interleukin-18 Gene Is Associated with the Presence of Hepatocellular Carcinoma in Hepatitis B Virus-Infected Patients

Cited by 33 publications

References 25 publications

Genetic polymorphisms -137 (rs187238) and -607 (rs1946518) in the interleukin-18 promoter may not be associated with development of hepatocellular carcinoma

Genetic polymorphisms -137 (rs187238) and -607 (rs1946518) in the interleukin-18 promoter may not be associated with development of hepatocellular carcinoma

The IL-8 Gene Polymorphisms and the Risk of the Hepatitis B Virus/Infected Patients

Lack of association between FOS polymorphisms and clearance of HBV infection as well as HCC occurrence

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