A Further Validation of Subareolar Injection Technique for Breast Sentinel Lymph Node Biopsy

D'Eredità, G; Giardina, C; Guerrieri, A. M.; Berardi, T

doi:10.1245/aso.2006.04.027

Cited by 20 publications

(12 citation statements)

References 26 publications

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“…In our study, the observed FN rate was 6.25%, not statistically different to other equivalent studies. Several series showed that FN SLNs occurred in tumours larger than 15 mm [34,38]. In this study, the false-negative SLN occurred in a 28-mm tumour.…”

Section: Discussionmentioning

confidence: 46%

Sentinel lymph node biopsy: Technique validation at the Setúbal Medical Centre - Portugal

Ferreira¹

2009

ecancer

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Aims:To evaluate the accuracy of sentinel lymph node biopsy in breast cancer patients at this institution, using combined technetium-99m (99mTc) sulphur colloid and patent blue vital dye.Methods:From March 2007 to July 2008, 50 patients with a tumour of less than 3 cm and with clinically negative axillary lymph nodes underwent sentinel lymph node biopsy (SLNB), followed by axillary lymph node dissection (ALND). Sub-areolar 99mTc sulphur colloid injection was performed the day before surgery, and patent blue vital dye was also injected sub-areolarly at least 5 minutes before surgery. Sentinel lymph node was identified during the surgical procedure, using a gamma probe and direct vision. All sentinel nodes underwent frozen section analysis. Later haematoxylin and eosin staining and immunohistochemical analysis were performed. Finally, SLNB was compared with standard ALND for its ability to accurately reflect the final pathological status of the axillary nodes.Results:The sentinel lymph node (SLN) was identified in 48 of 50 patients (96%). The number of sentinel lymph nodes ranged from one to four (mean 1.48) and non-sentinel nodes ranged from seven to 27 (mean 14.33). Of the 48 patients with successfully identified SLNs, 29.17% (14/48) were histologically positive. Sensivity of the SLN to predict axilla was 93.75%; accuracy was 97.96%. The SLN was falsely negative in one patient—6.25% (1/16).Conclusions:The SLNB represents a major advance in the surgical treatment of breast cancer as a minimally invasive procedure predicting the axillary lymph node status. This validation study demonstrates the accuracy of the SLNB and its reasonable false negative rate when performed in our institute. It can now be used as the standard method of staging in patients with early breast cancer at this institution.

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Section: Discussionmentioning

confidence: 46%

Sentinel lymph node biopsy: Technique validation at the Setúbal Medical Centre - Portugal

Ferreira¹

2009

ecancer

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“…We used the subareolar injection method in this study, because it identified the sentinel lymph nodes more quickly than the peritumoral method. Although the peritumoral method is now more widely performed the subareolar, one may replace it as a simpler detection method of sentinel lymph nodes [11][12][13][14].…”

Section: Discussionmentioning

confidence: 99%

Comparison of subareolar injection lymphoscintigraphy with the 1-day and the 2-day protocols for the detection of sentinel lymph nodes in patients with breast cancer

Seok

Kim

Heo³

et al. 2009

Ann Nucl Med

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“…A total of 1825 articles published up to June 2015 were identified from the literature search However, one study [31] reported on less than 50 patients and therefore was excluded, resulting in a total of 21 studies [24,[32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51] deemed eligible for further analysis.…”

Section: Selected Studiesmentioning

confidence: 99%

“…Patent Blue V was used in ten studies [33, 35, 38-41, 45, 48, 49, 51], methylene blue in six studies [24,34,37,39,43,50] and iso-sulphan blue in eight studies [24, 32, 36, 42-44, 46, 47]. The blue dye was injected on the morning of surgery in one study [49], just prior to surgery in 18 studies [24, 32-35, 37-43, 45-48, 50, 51] and the time of injection was not reported in two studies (table 1) [36,44].…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The blue dye was injected on the morning of surgery in one study [49], just prior to surgery in 18 studies [24, 32-35, 37-43, 45-48, 50, 51] and the time of injection was not reported in two studies (table 1) [36,44]. Blue dye was injected peri-tumorally in 12 studies [24,33,35,36,38,42,[45][46][47][48][49]51], sub-areolarly in three studies [37,39,50], intra-dermally in three studies [32,40,43], subdermally in two studies [34,41] and was not reported in one study [44]. Between 0-1ml of blue dye was injected in five studies [32,36,40,41,50], 1-2 ml in six studies [35,39,43,45,48,49], 2-5 ml in eight studies [24,33,37,38,42,46,47,51], more than 5 ml in one study [34] and one study…”

Section: Study Characteristicsmentioning

confidence: 99%

See 1 more Smart Citation

Blue Dye for Identification of Sentinel Nodes in Breast Cancer And Malignant Melanoma: A Systematic Review and Meta-Analysis

et al. 2016

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The combined technique (radioisotope and blue dye) is the gold standard for sentinel lymph node biopsy (SLNB) and there is wide variation in techniques and blue dyes used. We performed a systematic review and meta-analysis to assess the need for radioisotope and the optimal blue dye for SLNB. A total of 21 studies were included. The SLNB identification rates are high with all the commonly used blue dyes. Furthermore, methylene blue is superior to iso-sulfan blue and Patent Blue V with respect to false-negative rates. The combined technique remains the most accurate and effective technique for SLNB. In order to standardize the SLNB technique, comparative trials to determine the most effective blue dye and national guidelines are required.

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A Further Validation of Subareolar Injection Technique for Breast Sentinel Lymph Node Biopsy

Cited by 20 publications

References 26 publications

Sentinel lymph node biopsy: Technique validation at the Setúbal Medical Centre - Portugal

Sentinel lymph node biopsy: Technique validation at the Setúbal Medical Centre - Portugal

Comparison of subareolar injection lymphoscintigraphy with the 1-day and the 2-day protocols for the detection of sentinel lymph nodes in patients with breast cancer

Blue Dye for Identification of Sentinel Nodes in Breast Cancer And Malignant Melanoma: A Systematic Review and Meta-Analysis

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