Blue Dye for Identification of Sentinel Nodes in Breast Cancer And Malignant Melanoma: A Systematic Review and Meta-Analysis

Peek, Mirjam; Charalampoudis, Petros; Anninga, Bauke; Baker, Rose; Douek, Michael

doi:10.2217/fon-2016-0255

Cited by 43 publications

(31 citation statements)

References 52 publications

(218 reference statements)

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“…Sentinel lymph node detection usually involves a combination of labeling techniques using a radioisotope and a blue dye [ 56 ] . Dyes that can be used include isosulfan intolerance reactions.…”

Section: Dyes In Connection With Sentinel Lymph Node Biopsymentioning

confidence: 99%

Pre‐ and perioperative aspects of dermatosurgery

Müller

Hübner

Thieme‐Ruffing

et al. 2017

J Deutsche Derma Gesell

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Die Dermatochirurgie nimmt hinsichtlich vieler Punkte eine Sonderstellung unter den operativen Fächern ein. Hierzu gehört in erster Linie die Tatsache, dass bis auf weni-ge Ausnahmen fast alle Eingriffe traditionell in Lokal-bzw. Regionalanästhesie und oft auch in räumlich-infrastruktureller Trennung von den großen Zentral-Operationssälen stattfinden können. Die peri-und postoperative Überwachung obliegt dabei dem der-matochirurgischen Operationsteam. Das sui generis kleinere OP-Team hat somit eine ganze Reihe perioperativer Notwendigkeiten zu beachten, um die sich in den "großen" chirurgischen Fächern eine Vielzahl verschiedener beteiligter Fachgruppen gemeinsam kümmern. Hierzu gehören neben Hygieneaspekten, Kenntnissen in der Überwachung der Patienten sowie dem Aspekt der surgical site infections auch Fragen zur postope-rativen Schmerztherapie sowie detailliertes pharmakologisches Wissen über die zur Anwendung kommenden Lokalanästhetika und das Handling der damit assoziierten toxischen und allergischen Reaktionen. Eine interdisziplinäre Zusammenarbeit und Verantwortung für den Patienten ist notwendig und erfordert die Erarbeitung und Um-setzung qualitätsorientierter und evidenzbasierter Handlungsanweisungen, die im der-matochirurgischen OP-Setting meist weit über das eigentliche Fach hinausgehen. Ziel dieses Weiterbildungsartikels soll die komprimierte Darstellung der genannten fach-übergreifenden Standpunkte bezüglich der wichtigsten perioperativen Aspekte sein. Summary Dermatosurgery occupies an exceptional position among all surgical disciplines. Above all, this includes the fact that, with very few exceptions, the vast majority of surgical interventions can be performed under local or regional anesthesia, usually in smaller procedure rooms that are spatially separated from larger operating suites. Thus, peri-and postinterventional patient monitoring is the responsibility of the dermatosurgeon and his team. Though inherently smaller, this team still has to observe numerous peri-operative requirements that-in larger surgical specialties-would be attended to by a host of various specialists working in concert. Said requirements include hygienic aspects , knowledge concerning pre-and intraoperative patient monitoring, managing surgical site infections, adequate postsurgical pain management, as well as detailed pharmacological knowledge with respect to common local anesthetics and the toxic and allergic reactions associated therewith. Not only does this require interdisciplinary collaboration and shared responsibility for the patient. It also necessitates the development and implementation of quality-oriented and evidence-based guidelines that, in the dermatosurgical setting, usually extend far beyond the scope of the specialty per

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Section: Dyes In Connection With Sentinel Lymph Node Biopsymentioning

confidence: 99%

Pre‐ and perioperative aspects of dermatosurgery

Müller

Hübner

Thieme‐Ruffing

et al. 2017

J Deutsche Derma Gesell

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“…In the SLNB procedure, various methods are routinely used in the evaluation of SLNs and LCs, including blue dye and radioisotopes (Hokimoto et al 2018;Peek et al 2017). Multiple studies have established the validity of blue dye as a marker for SLNs; thus, it is currently the most widely used method during surgery (Peek et al 2017). Nonetheless, it has its own set of disadvantages.…”

Section: Introductionmentioning

confidence: 99%

How Pre-operative Sentinel Lymph Node Contrast-Enhanced Ultrasound Helps Intra-operative Sentinel Lymph Node Biopsy in Breast Cancer: Initial Experience

Cheng

et al. 2019

Ultrasound in Medicine & Biology

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We aimed to evaluate the value of sentinel lymph node contrast-enhanced ultrasound (SLN-CEUS) and surface tracing for the biopsy of intra-operative sentinel lymph nodes (SLNs). Between June 2015 and December 2017, a total of 453 patients with early invasive breast cancer were recruited. Patients received an intradermal injection of microbubble contrast agent around the areola on the day before surgery. The locations and sizes of lymphatic channels (LCs) and SLNs were marked on the body surface using gentian violet. Then, injection of double blue dye was performed half an hour before surgery. We compared the pathway of LCs and the location of SLNs obtained from SLN-CEUS and blue dye during surgery. Among the 453 patients, the mean numbers of LCs and SLNs detected by SLN-CEUS were 1.42 and 1.72, respectively, and the coincidence rate was 98.2% compared with blue dye during surgery. The median distance from the SLN to skin measured by preoperative CEUS and blue dye was 1.95 § 0.69 and 2.03 § 0.87 cm (p = 0.35). There were three SLN enhancement in our research, including homogeneous enhancement, inhomogeneous enhancement and no enhancement, with the sensitivity, specificity, positive predictive value and negative predictive value of SLN-CEUS for the diagnosis of SLNs being 96.82%, 91.91%, 87.54% and 98.01%, respectively. SLN-CEUS with skin marking can identify the pathway of LCs and the location of the SLN before surgery, measure the distance from the SLN to skin and determine if the SLN is metastatic. SLN-CEUS can be used as an effective complement to the blue dye method.

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“…MB continues to be applied and investigated as treatment for a variety of medical applications in the clinical setting, including methemoglobinemias and ifosfamide-induced encephalopathy ( 170 , 171 ). MB has also been used to identify breast cancer ( 101 ) and neuroendocrine tumors ( 73 ), and is commonly used for SLN mapping ( 38 , 39 ), as well as the identification of urologic tumors ( 51 , 52 ) and tumors in the parathyroid glands ( 130 ).…”

Section: Current Clinical Use Of Fluorescence Imaging Probesmentioning

confidence: 99%

Fluorescence-Guided Surgery

et al. 2017

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Surgical resection of cancer remains an important treatment modality. Despite advances in preoperative imaging, surgery itself is primarily guided by the surgeon’s ability to locate pathology with conventional white light imaging. Fluorescence-guided surgery (FGS) can be used to define tumor location and margins during the procedure. Intraoperative visualization of tumors may not only allow more complete resections but also improve safety by avoiding unnecessary damage to normal tissue which can also reduce operative time and decrease the need for second-look surgeries. A number of new FGS imaging probes have recently been developed, complementing a small but useful number of existing probes. In this review, we describe current and new fluorescent probes that may assist FGS.

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Blue Dye for Identification of Sentinel Nodes in Breast Cancer And Malignant Melanoma: A Systematic Review and Meta-Analysis

Cited by 43 publications

References 52 publications

Pre‐ and perioperative aspects of dermatosurgery

Pre‐ and perioperative aspects of dermatosurgery

How Pre-operative Sentinel Lymph Node Contrast-Enhanced Ultrasound Helps Intra-operative Sentinel Lymph Node Biopsy in Breast Cancer: Initial Experience

Fluorescence-Guided Surgery

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