A fusion protein of flagellin and ovalbumin suppresses the TH2 response and prevents murine intestinal allergy

Intralymphatic treatment of flagellin-ovalbumin mixture reduced allergic inflammation in murine model of allergic rhinitis

“…Several studies have revealed the effectiveness of flagellin in terms of adjuvants as well as its ability for immunomodulation (2,(7)(8)(9). Although several flagellin-based vaccines for infectious diseases have already entered clinical trials, the potential uses of flagellin as an adjuvant for immunomodulation need to be further explored.…”

Flagellin suppresses experimental asthma by generating regulatory dendritic cells and T cells

“…[37][38][39][40] Myeloid DCs might be the major player rather than plasmacytoid DCs. 13,36 Ubiquitin edition enzyme A20, a quiescent factor against activation counteracting nuclear factor kB signaling, might play a role in the development of rDCs. 41 Treatment of DCs with high LPS concentrations appeared to upregulate A20 and consequently suppressed allergic asthma.…”

“…12 A fusion protein of OVA and flagellin inhibited IgE-mediated intestinal allergy in mice. 13 TLR5 expression and function have been impaired in asthmatic patients. 14 TLR5 expression in human umbilical cord blood was inversely associated with the development of atopic dermatitis.…”

Reevaluating the hype: four bacterial metabolites under scrutiny

“…Schülke et al [70,71] reported that intraperitoneal administration of fl agellin-ovalbumin fusion protein prevented intestinal allergy in mice. On the other hand, Wilson et al [72] instilled fl agellin together with ovalbumin into the airways of mice in which it induced strong allergic airway responses to ovalbumin.…”